Suritra Bandyopadhyay @suritra.bsky.social · 28/08/2026We wondered: rather than treating pH as a confounding variable, could we encode it into the measurement itself? We used the power of ¹⁹F NMR, to make F-pHOx such that, from the same spectrum we encode two pieces of chemical information, in one ¹⁹F readout. 🧪 020
Suritra Bandyopadhyay @suritra.bsky.social · 28/08/2026Activity-based sensors report on molecules through their chemical reactivity. But there’s a catch: reactivity depends on the environment. A change in pH can alter both analyte reactivity and probe response. So, is a weaker signal really less analyte… or just different chemistry?static.klipy.comOakley the Sciencedog's Chemical ReactionALT: Oakley the Sciencedog's Chemical Reaction 110
Suritra Bandyopadhyay @suritra.bsky.social · 28/08/2026🧵 Excited to share our new work in ACS Sensors. Can we measure what a molecule is doing AND the chemical environment it is doing it in? We developed a ¹⁹F activity-based barcoding approach to measure pH + analyte reactivity using NMR/MRI simultaneously. 🧪🧲 pubs.acs.org/ascefj/artic...pubs.acs.org19F Activity-Based Barcoding Enables Simultaneous Measurement of pH and Analyte ReactivityAbstractActivity-based sensing (ABS) probes are designed to report on analyte activity, but their readouts are often influenced by local pH. Because both p 222
Suritra Bandyopadhyay @suritra.bsky.social · 23/04/2026It’s not unknown that tumors have a BIG sweet tooth but can that metabolic dependency be exploited for therapy? In this work, we show GLUT1-targeted glucose-decorated gold nanorods show higher selective tumor uptake and improved photothermal therapy! pubs.acs.org/doi/10.1021/...pubs.acs.orgMetabolic Trojan Horse: Multivalent Glucose Ligand Modified Near-Infrared-Absorbing Gold Nanorods for Targeted Photothermal TherapyNanoparticle-based photothermal therapy (PTT) provides localized tumor ablation but remains limited by off-target accumulation and the need for high systemic doses. To address these challenges, we dev... 111
Reposted by Suritra BandyopadhyayMatt Bogyo @mbogyo.bsky.social · 25/02/2026Our latest work on fluorescent probes for imaging infections in vivo is out. Check it out! www.biorxiv.org/content/10.6...biorxiv.org 0126
Suritra Bandyopadhyay @suritra.bsky.social · 17/12/2025Worked on this paper with Joe out in ACS Chemical Biology. We developed and evaluated AAP, an ALDH1A1 activated photosensitizer that stays OFF until it encounters ALDH1A1 in tumor cells and light, to enable precise localized photo toxicity! doi.org/10.1021/acsc...doi.orgDonor-PeT Control of Intersystem Crossing Enables ALDH1A1-Activated Photodynamic TherapyAldehyde dehydrogenase 1A1 (ALDH1A1) is highly expressed in therapy-resistant and metastatic cancers and represents a clinically relevant biomarker for selective activation strategies. We report AAP, ... 020
Reposted by Suritra BandyopadhyayYamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n 29547230
Reposted by Suritra Bandyopadhyayprideacs.bsky.social @prideacs.bsky.social · 13/06/2025Applications are now open for the 2026 ACS Pride Merck Graduate Research Award! Share this with anyone who might be interested in applying! Applications will be due on Friday, Sept. 5th, 2025. Check out our website for more information! #ACSPride #ACS #ElevatingProfessionalism #HumansOfSTEM #LGBTQ 034
Reposted by Suritra Bandyopadhyayshenvi.bsky.social @shenvi.bsky.social · 18/11/2024If you like total synthesis and Wordle, check out Synthordle, a retrosynthetic analysis game created by Shenvi Lab associates Kevin Zong (GS 2) and Jonah Luo (HS sophomore!). shenvilab.github.io/Synthordle/ Easy problems for Sophomore OChem, hard problems for advanced practitioners. 99829
Suritra Bandyopadhyay @suritra.bsky.social · 18/11/2024I think this will be a perfect first post for #chemsky Really grateful to the Beckman Foundation for the Graduate Research Fellowship Award. I am excited to work on using ultrasound for designing activatable theranostics! Here's the recent news article: beckman.illinois.edu/about/news/a...beckman.illinois.eduMeet the 2024 Beckman Institute Graduate Fellows 030