iiinova — where your digital self keeps evolving

Reposted by Alex Coates, PhD

Jem Arnold @jemarnold.bsky.social · 25/07/2026

Another call for input! 📢 CLINICIANS, COACHES, and ATHLETES managing recovery from surgery for flow limitations in the iliac artery FLIA / endofibrosis We'd love to hear your experiences to help improve care for athletes. Please contact email below 👇 #cycling #sportsmedicine #sportmedicine

HAVE YOU HAD SURGERY FOR FLOW LIMITATIONS IN THE ILIAC ARTERY?

HELP IMPROVE FUTURE CARE FOR ATHLETES

We want to hear from you for an international research study

WHO CAN PARTICIPATE

You can participate if you:

are 18 years or older
have had surgery for flow limitations in the iliac artery (FLIA/endofibrosis)
can complete an English questionnaire

WHAT DOES PARTICIPATION INVOLVE

Online questionnaire
Approximately 15–20 minutes
Completely voluntary

JOIN THE STUDY

contact email: flia@mmc.nl

PLEASE SHARE

Do you know other athletes who have had iliac artery surgery?

Please send them this study information

STUDY INFORMATION

The study is conducted by the INSITE group:
International Study group for Identification and Treatment of Endofibrosis

Questions: flia@mmc.nl

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Reposted by Alex Coates, PhD

David Ho @davidho.bsky.social · 17/07/2026

A reminder: The US, by being the largest historical CO₂ emitter, has caused $10 trillion in global climate damage since 1990. A quarter of this impact is felt domestically, but it disproportionately affects poorer countries.

theguardian.com

US has caused $10tn worth of climate damage since 1990, research finds

US, top carbon emitter in history, has ‘a lot of responsibility’ for causing ‘substantial’ harm globally, scientist says

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Alex Coates, PhD @superalex-c.bsky.social · 10/06/2026

4. Athletes started out the race focusing on their personal goals and ways to manage pain over the 6d race. However, by the end, they had reframed the experience to one of collective suffering in order to get through it. This suggests even in "lone wolf" sports, success comes from shared experience

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Alex Coates, PhD @superalex-c.bsky.social · 10/06/2026

3. Top athletes adopted gait patterns that looked more like a shuffle (termed "terrestrial gait pattern"), rather than typical running gaits. They had longer stance times, lower flight times, and less vertical forces. This may have allowed them to run further with less fatigue than a normal run gait

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Alex Coates, PhD @superalex-c.bsky.social · 10/06/2026

2. The top athlete, who broke 12 world records at the time of the event, did not have lab-based physiological attributes that set her apart from the next top finishers. Instead, it appears her previous experience and willingness to push through pain and physical breakdown that was the key to success

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Alex Coates, PhD @superalex-c.bsky.social · 10/06/2026

Four cool findings were: 1. Three of the women had the highest total daily energy expenditures recorded in female athletes to date (to our knowledge), with our top athlete recording > 11,000 kcals burned per day! (and ~150,000 steps/day)

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Alex Coates, PhD @superalex-c.bsky.social · 14/04/2026

Another successful EPPL showing at BPK research day! @sfuscience.bsky.social www.exercisephysiologyandperformancelab.com/whats-going-on

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Alex Coates, PhD @superalex-c.bsky.social · 24/02/2026

Yes, it’s tricky. There’s a mechanistic rationale as to how it could work, as it helps normalize preload similarly to drugs (such as in this study: www.sciencedirect.com/science/arti...). That said, over-exertion will always cause PEM, so staying within that energy envelope will be the tricky part

sciencedirect.com

Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Placebo-Controlled Trial of Pyridostigmine

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by intractable fatigue, postexertional malaise, and orthostatic intoleran…

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Alex Coates, PhD @superalex-c.bsky.social · 20/02/2026

Contact information can be found here: www.exercisephysiologyandperformancelab.com/get-involved

exercisephysiologyandperformancelab.com

Get Involved — Exercise Physiology and Performance Lab

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Alex Coates, PhD @superalex-c.bsky.social · 20/02/2026

Note: this is not an exercise training or rehabilitation study, and participation is only intended for individuals who can tolerate gentle activity and be in public spaces without triggering PEM. Participants should also be comfortable with swimming, although flotational devices are welcomed.

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Alex Coates, PhD @superalex-c.bsky.social · 20/02/2026

A light cycling session is available as an optional comparator for those with mild conditions who feel comfortable doing so. If you feel you may be a suitable candidate, please reach out for more details.

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Alex Coates, PhD @superalex-c.bsky.social · 20/02/2026

Recruitment: We are recruiting adults with mild-to-moderate ME/CFS and related conditions for this study examining short-term symptom and autonomic responses to gentle swimming. Participants will choose their own intensity and duration and may stop at any time. This pilot study is entirely remote.

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Alex Coates, PhD @superalex-c.bsky.social · 20/02/2026

Swimming may be the ideal form of movement for those that can tolerate it, as the horizontal posture and hydrostatic pressure of water supports passive venous return and reduces orthostatic stress, while cool water exposure may influence autonomic and inflammatory responses.

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Alex Coates, PhD @superalex-c.bsky.social · 20/02/2026

This treatment caused harm, as exercise exacerbated symptoms and led to a worsening of disease severity. Today, it is recommended that patients pace their energy carefully, and stay within their energy envelopes in order to prevent post-exertional malaise / symptom exacerbation.

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Alex Coates, PhD @superalex-c.bsky.social · 20/02/2026

Background: PwME/CFS experience profound exercise intolerance and post-exertional malaise. Historically, ME/CFS was seen as a psychosomatic disorder, and physiological symptoms were thought to be due to deconditioning. Treatment was Graded Exercise Therapy and Cognitive Behavioural Therapy.

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Reposted by Alex Coates, PhD

Putrino Lab @putrinolab.bsky.social · 17/02/2026

Crucial paper published Friday that deserves much more attention in the #LongCOVID world: www.nature.com/articles/s41... TLDR: 13/15 immunocompromised patients who had chronic COVID infections (>200 days) cleared the virus in under 2 weeks when given combo antivirals/monoclonals 1/

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Alex Coates, PhD @superalex-c.bsky.social · 31/01/2026

Most flowmeters don’t do well with very high ventilations either - so that probably compounded any calibration errors

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Alex Coates, PhD @superalex-c.bsky.social · 31/01/2026

Occam’s razor says this is a cart calibration / setup issue!

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Reposted by Alex Coates, PhD

Long Covid Advocacy @longcovidadvoc.com · 27/01/2026

6/ Invasive cardiopulmonary exercise testing (iCPET) in subsets identified preload failure in 96% of Long Covid and 92% of ME patients tested.

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Reposted by Alex Coates, PhD

Long Covid Advocacy @longcovidadvoc.com · 27/01/2026

1/ A new study from Brigham and Women’s Faulkner Hospital, led by prominent researchers Peter Novak, David Systrom, and colleagues, compared 143 Long Covid, 170 ME/CFS, 73 healthy controls, and 290 hEDS patients to map shared autonomic and neurovascular dysfunction. 🧵

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Reposted by Alex Coates, PhD

Sportrix A. Birklbauer @sportrixanita.bsky.social · 24/01/2026

new 🧵 Maybe myocardial fibrosis is an arrhythmogenic substrate which is activated by intense exercise in certain veteran athletes Timing and Relationship of Ventricular Arrhythmia with Exercise Patterns in Veteran Male Endurance Athletes url: academic.oup.com/eurjpc/artic...

academic.oup.com

The Timing and Relationship of Ventricular Arrhythmia with Exercise Patterns in Veteran Male Endurance Athletes

AbstractAim. To determine whether exercise training patterns were associated with the incidence and timing of ventricular arrhythmia in veteran male endura

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Reposted by Alex Coates, PhD

Julia MV @julialmv.bsky.social · 20/01/2026

2 million! The scale of people that this review reached is incredible I can only imagine what the next 3 years of researching and publishing on Long COVID has in store for us 🎢

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Reposted by Alex Coates, PhD

Tom Kindlon @tomkindlon.bsky.social · 13/01/2026

Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome www.frontiersin.org/journals/med... Screenshot from latest Science for ME weekly update #MEcfs #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome

Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome — Martini Sasso et al.
"We identified a significant reduction in TRPM3 ion channel function in NK cells isolated from ME/CFS patients, both in response to stimulation with the agonist PregS (p < 0.0001) and in suppression of activation using ononetin (p < 0.0001)."

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Reposted by Alex Coates, PhD

Nature Portfolio @natureportfolio.nature.com · 30/12/2025

The shingles vaccine reduced the probability of new #dementia diagnoses by around one-fifth over seven years, according to a large-scale study of a population in Wales, UK, reported in Nature in April. go.nature.com/4460AE4 🧪

This is figure 3, which shows the effect of the zoster vaccine on new diagnoses of dementia.

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Reposted by Alex Coates, PhD

Michele Zanini @mzaniniphysiology.bsky.social · 17/12/2025

Together with Andy Jones and Lars Nybo, here is our brief view about: - How Physiological Resilience and Durability should be distinguished - How they link the abundant literature on fatigue development with endurance performance models. journals.physiology.org/doi/full/10....

journals.physiology.org

Defining physiological resilience and durability in the context of endurance performance modeling | Journal of Applied Physiology | American Physiological Society

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Reposted by Alex Coates, PhD

American Physiological Society @apsphysiology.bsky.social · 16/12/2025

How fast blood pressure pulses move through your arteries shows more than stiffness. It reflects artery health and whole body factors that shape your heart risks. More in APS Publications AJP-Heart: ow.ly/zGNC50XHCyS #ArticlesInPresS 🧪 📷: iStock

Doctor in white coat drawing a red heartbeat line ending in a heart symbol with a marker.

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Reposted by Alex Coates, PhD

APS Publications @apspublications.bsky.social · 15/12/2025

New report in Journal of Applied Physiology studies whether different levels of #carb ingestion by elite male #marathon #runners confer a metabolic advantage by better maintaining whole body rates of carb oxidation & improving running economy 🏃‍♂️‍➡️ ow.ly/wg9j50XJSgA

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Alex Coates, PhD @superalex-c.bsky.social · 27/11/2025

This suggests that athletes may be well adapted to handle high glucose flux, but when the training load is reduced there could be a window of vulnerability. Exciting area for further research! @apnmjournal.bsky.social @hplburr.bsky.social

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Alex Coates, PhD @superalex-c.bsky.social · 27/11/2025

There’s emerging evidence that endurance athletes may have worse glycemic control than healthy active individuals. In this study we found that glycemic variability and glucose tolerance was worsened in the recovery week following overload training: cdnsciencepub.com/eprint/ZFQYU...

cdnsciencepub.com

Alterations in glycemic control and glucose tolerance following overtraining in endurance athletes

Previous research has demonstrated attenuated exercising carbohydrate oxidation and circulating glucose when endurance athletes are functionally overreached; however, whether free-living glycemic cont...

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Reposted by Alex Coates, PhD

ACOG @acog.org · 22/09/2025

ACOG reaffirms that acetaminophen is safe for managing pain and fever during pregnancy. No reputable studies support suggestions like those in HHS’s recent announcement linking acetaminophen use in pregnancy to autism; in fact, high-quality studies show no such risk. bit.ly/47Wxc59

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Reposted by Alex Coates, PhD

John Anderson 🇨🇦 @janderz8.bsky.social · 18/09/2025

Hi #canadian researchers - please sign this petition to help ensure funding isn’t cut to tri council agencies (NSERC, SSHRC, and CIHR). We’re looking at potential 15% cuts to ALL federal spending including grants win.newmode.net/canadianasso...

win.newmode.net

New/Mode | Make your voice impossible to ignore

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Reposted by Alex Coates, PhD

Glen Pyle | Womens Heart Health ❤️‍🩹🖇️ @glenpyle.bsky.social · 30/08/2025

Do we really need to do research specifically on women's health? The REBOOT trial finds beta-blockers - a standard therapy for heart attacks - causes harm in women, but not men. Yes. The answer is yes. academic.oup.com/eurheartj/ar...

academic.oup.com

Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial

AbstractBackground and Aims. Recent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients witho

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Reposted by Alex Coates, PhD

Putrino Lab @putrinolab.bsky.social · 14/08/2025

Really proud of my team for getting this out. It has been a heavy lift. When we opened the Cohen Center for Recovery from Complex Chronic Illness, we wanted to create a place that could provide the very best of care for people with #LongCOVID, #MECFS, www.beckershospitalreview.com/quality/pati... 1/

beckershospitalreview.com

Mount Sinai publishes 1st US guide for infection-linked chronic illnesses - Becker's Hospital Review | Healthcare News & Analysis

New York City-based Mount Sinai Health System has released the country’s first clinical manual for treating infection-associated chronic illnesses, according to an Aug. 13 news release. The clinical ...

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Reposted by Alex Coates, PhD

International Journal of Sport Nutrition and Exercise Metabolism @hk-ijsnem.bsky.social · 24/07/2025

Find out more here! 🔗 doi.org/10.1123/ijsn...

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Reposted by Alex Coates, PhD

International Journal of Sport Nutrition and Exercise Metabolism @hk-ijsnem.bsky.social · 24/07/2025

Is magnesium an effective topical treatment to aid recovery?🧴 Coates et al. (2025) conducted a randomised, double-blind, placebo-controlled study to evaluate the potential for a commercial topical magnesium gel to reduce muscle soreness after unaccustomed exercise.

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Jamie Burr @hplburr.bsky.social · 02/06/2025

In Québec City for a fantastic long weekend of ice hockey research—great conversations with Canadian and international experts bringing diverse backgrounds and fresh perspectives to the game 🏒

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Reposted by Alex Coates, PhD

Jamie Whitfield, Ph.D. @jwhitfie.bsky.social · 29/05/2025

Unsurprisingly, standing room only for the one and only @louisemburke.bsky.social delivering the ACSM Presidents Lecture. #ACSM25 #GOAT

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Reposted by Alex Coates, PhD

International Journal of Sport Nutrition and Exercise Metabolism @hk-ijsnem.bsky.social · 23/05/2025

🚨LEAD FEATURE ARTICLE🚨 July 2025✨ Another fantastic paper from @monash_uni has been selected as the lead feature for our July issue! ‘The Effects of Prebiotic Supplementation on Markers of Exercise-Induced Gastrointestinal Syndrome in Response to Exertional Heat Stress’

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Reposted by Alex Coates, PhD

Daniel Lakens @lakens.bsky.social · 07/05/2025

The journal of Sports and Sciences will now require mandatory sample size estimation and justification www.tandfonline.com/doi/full/10.... This is an excellent step that will improve scientific papers. I expect many other journals will follow.

tandfonline.com

Sample size estimation revisited

Published in Journal of Sports Sciences (Ahead of Print, 2025)

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Reposted by Alex Coates, PhD

Long COVID Physio @longcovidphysio.bsky.social · 06/05/2025

“Skeletal muscle properties in #LongCOVID and #ME/CFS differ from those induced by bed rest” Objective science debunking deconditioning theories! 💥 🎤 @patientled.bsky.social www.medrxiv.org/content/10.1...

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