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High-throughput growth assays show that cyclic-oligonucleotide-based anti-phage signalling systems modulate Vibrio cholerae sensitivity to antifolates, and ultimately trigger cell lysis by these drugs...

Bacteria use diverse defences against viral predators called bacteriophages. A method to identify antibacterial counter-defences in viral genomes has revealed striking modes of defence inhibition. Pre...

Two recent studies provide mechanistic understanding of how bacteria employ the Gabija system for defence against phages, as well as how phages use anti-defence proteins to overcome bacterial immunity...

The discovery could lead to better treatments for severe nausea and vomiting during pregnancy.

Antiviral defence systems build the prokaryotic immune system and their proper regulation is vital f