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Stephan Hacker @stephanhacker2.bsky.social · 4m

The Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov was an amazing meeting. my.bps.ac.uk/events/detai... I am very happy that I was invited to present some of our most recent work. Photo credit: @aekiib.bsky.social (1/7)

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Stephan Hacker @stephanhacker2.bsky.social · 17h

A true firework of covalent drug discovery to close out the Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov! Ed Tate presented a variety of exciting projects of his group. pubs.acs.org/jacsat/artic... #CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science

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Stephan Hacker @stephanhacker2.bsky.social · 17h

Interesting talk by Michael Bodnarchuk from @astra-zeneca.bsky.social at #CovModDrugDiscov. He talked about the use of computational tools to discover covalent, brain-penetrant KRAS G12C inhibitors. #CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science

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Stephan Hacker @stephanhacker2.bsky.social · 18h

Exciting talk by Yoav Shamir from the group of Nir London at #CovModDrugDisvov! He talked about cofolding in Alphafold3 to identify #CovalentInhibitors with novel structures for BTK. pubs.acs.org/jacsat/artic... #DrugDiscovery #Kinase #ChemSky #ChemBio #Science @britpharmsoc.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 19h

Interesting talk by Chloe Oxford from GSK at #CovModDrugDiscov. She talked about a MALDI-TOF-MS-based assay to characterize the binding of #CovalentInhibitors to challenging proteins with resolution of the binding site. #DrugDiscovery #ChemBio #ChemSky #Science

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Stephan Hacker @stephanhacker2.bsky.social · 21h

Interesting talk by Federica Raguseo at #CovModDrugDiscov. She talked about a phenotype-first approach to covalent drug discovery on the example of TYMS. www.biorxiv.org/content/10.6... #CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science @britpharmsoc.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 22h

Exciting talk by @meganwright.bsky.social at #CovModDrugDiscov. She talked about new chemical methods to make libraries of covalent compounds and using them in MS-based and phenotypic screens. pubs.rsc.org/cb/article/7... #DrugDiscovery #ChemSky #ChemBio #Science @britpharmsoc.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 22h

Interesting talk by Darrin McKenzie at #CovModDrugDiscov. He talked about, how they set up an automated platform to study protein expression levels and cysteine engagement in living cells. #CovalentInhibitor #DrugDiscovery #ChemBio #ChemSky #ChemicalProteomics #Science

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Stephan Hacker @stephanhacker2.bsky.social · 23h

Always great to see the amazing work by Patrick Zanon in our group highlighted in the talk of others. www.nature.com/articles/s41... #CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #ChemPro #ProteoProbes @britpharmsoc.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 23h

Exciting talk by William McCarthy at #CovModDrugDiscov. He talked about their amazing capacities at the Francis Crick Institute for #chemoproteomic profiling of cysteines. Great insights into the use of #MachineLearning to predict more selective compounds. (1/2) chemrxiv.org/doi/full/10....

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Stephan Hacker @stephanhacker2.bsky.social · 23h

The 2nd day of #CovModDrugDiscov gets on the way with an inspiring talk by Steven Gygi. He talked about the power of TMT technologies for multiplexing to arrive at high-throughput residue-specific chemoproteomics. #CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #ChemicalProteomics #Science

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

The first day of #CovModDrugDiscov comes to an end with an exciting talk by @mbogyo.bsky.social. He talked about covalent probes to visualize bacterial infections and tumors. Great to see them take this concept to phase 3 studies for fluorescence-guided surgery. link.springer.com/article/10.1...

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

Inspiring talk by Scott Lovell at #CovModDrugDiscov. He talked about the development of macrocyclic #peptides into covalent inhibitors targeting lysines using SuFEx chemistry. www.biorxiv.org/content/10.6... #DrugDiscovery #ChemSky #ChemBio #Science @britpharmsoc.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

Interesting talk by @ljwalport.bsky.social at #CovModDrugDiscov. She talked about the discovery of potent peptide-based #CovalentInhibitors using mRNA display. www.nature.com/articles/s42... #mRNA #RNA #DrugDiscovery #ChemBio #ChemSky #Science @britpharmsoc.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

Interesting talk by Madeeha Ali at #CovModDrugDiscov. She talked about her exciting work on studying the kinetics of #CovalentInhibitors. bpspubs.onlinelibrary.wiley.com/doi/10.1111/... #DrugDiscovery #Kinetics #ChemSky #ChemBio

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

Great talk by David Heppner (@heppnerd.bsky.social) at #CovModDrugDiscov. He gave exciting insights into rigorously characterizing #CovalentInhibitors using crystal structures and kinetics. pubs.acs.org/abmcb8/artic... #DrugDiscovery #ChemSky #ChemBio #Science

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

Insightful talk by Matthias Gehringer at #CovModDrugDiscov. He gave great insights into his group's work on making new kinases amenable to covalent drug discovery at cysteine and beyond. onlinelibrary.wiley.com/doi/10.1002/... #CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #Kinase

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

We had an amazing poster session at #CovModDrugDiscov! I learned a lot about new warheads, covalent binder optimization and methods to measure target engagement. Thank you to all presenters for sharing their amazing science. #DrugDiscovery #ChemSky #ChemBio #Science @britpharmsoc.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

Interesting talk by Jonathan Pettinger from GSK at #CovModDrugDiscov. He talked about the power of direct-to-biology (D2B) approaches for fast SAR studies of #CovalentInhibitors. chemrxiv.org/doi/10.26434... #D2B #DirectToBiology #DrugDiscovery #ChemBio #ChemSky #Science

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

#CovModDrugDiscov continues with an interesting talk by Mandy Ferdinand from Cancer Research Horizons. She talked about methods to characterize covalent hits with a special focus on binding kinetics. #CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

The Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov is off to a great start with an insightful talk by Matt Bilyard from Roche. He talked about how they select targets for covalent drug discovery and then find and develop covalent binders. #CovalentInhibitor #ChemBio #ChemSky

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Stephan Hacker @stephanhacker2.bsky.social · 07/10/2026

And we are on the way with the Covalent Modulation in Drug Disvovery Conference by @britpharmsoc.bsky.social. Looking forward to two days filled with cutting-edge covalent drug discovery. #ChemBio #ChemSky #DrugDiscovery #CovalentInhibitor

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Stephan Hacker @stephanhacker2.bsky.social · 06/10/2026

How can covalency be used in the most effective way to accelerate drug discovery? I am very happy to be on the way to the conference "Covalent Modulation in Drug Discovery" by the @britpharmsoc.bsky.social in Cambridge to discuss this and related question in the coming two days. (1/3)

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Stephan Hacker @stephanhacker2.bsky.social · 01/10/2026

And we are live! We are very happy to say that as of today the registration and abstract submission for ABPP2027 are open: www.universiteitleiden.nl/abpp2027/reg... www.universiteitleiden.nl/abpp2027/reg... (1/8)

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Stephan Hacker @stephanhacker2.bsky.social · 29/09/2026

Amazing talk by @ninahartrampf.bsky.social at the @chembiotalks.bsky.social. She talked about the power of #FlowChemistry for the synthesis of peptides and proteins on the example of the challenging synthesis of #Myc with various PTMs. pubs.rsc.org/sc/article/1... #ChemBioTalks #ChemBio #Science

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Stephan Hacker @stephanhacker2.bsky.social · 27/09/2026

Great to see our colleague @sebastianpomplun.bsky.social from the @led3hub.bsky.social highlighted in the #MedChemBioConversations series by @euromedchem.bsky.social. Check out the interview to learn more about him and his science. www.efmc.info/medchemwatch... #ChemSky #ChemBio #DrugDiscovery

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Stephan Hacker @stephanhacker2.bsky.social · 25/09/2026

It was great to host Christian Hackenberger yesterday for a very well attended @led3hub.bsky.social Lecture. He gave amazing insights into the synthesis of highly efficacious antibody-drug conjugates as well as into intracellular delivery of proteins. (1/13) #DrugDiscovery #ChemSky #ChemBio #ADC

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Stephan Hacker @stephanhacker2.bsky.social · 22/09/2026

Are you looking for Master's studies in Chemistry or Life Science & Technology? Make sure to check out the great opportunities at @leidenscience.bsky.social! If you want to learn more, you can sign up for our Master's Online Open Day on October 15th. For more information, visit: shorturl.at/rkDj0

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Stephan Hacker @stephanhacker2.bsky.social · 14/09/2026

How can we figure out, how protein activity is controlled in space and time? I am very happy that @janavolaric.bsky.social joined the @led3hub.bsky.social as an NWO VENI fellow this year to address exactly this question using exciting optical tools. (1/3) #ChemSky #ChemBio #Light #LipidTime #Lipids

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Stephan Hacker @stephanhacker2.bsky.social · 14/09/2026

Are you interested in the newest and most exciting research in Chemical Biology? The Advances in Chemical Biology on January 26th and 27th, 2027, in Frankfurt, Germany, might just be the event for you! Check out the details here: www.dechema.de/en/ChemBio2027 (1/4)

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Stephan Hacker @stephanhacker2.bsky.social · 11/09/2026

Interesting paper by the groups of Bradley Pentelute and Aaron Nile in Chemical Science. They developed an on-resin, intermolecular Heck reaction to diversify acrylamides for covalent hit discovery using coPELs. pubs.rsc.org/sc/article/d... #ChemSky #ChemBio #DrugDiscovery #CovalentInhibitor

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Stephan Hacker @stephanhacker2.bsky.social · 10/09/2026

Do you have experience in Organic Synthesis or Chemical Biology and are you looking for an exciting #postdoc position, in which you can apply your skills to the most exciting questions in microbiology? There are great opportunities available in the lab of Aaron Wright at Baylor! shorturl.at/2HQb7

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Stephan Hacker @stephanhacker2.bsky.social · 31/08/2026

How can more stable antibody-drug conjugates be synthesized and translated into the clinics? I am excited that we will host Christian Hackenberger for a @led3hub.bsky.social Lecture, in which he will discuss, how his group is answering this question. www.universiteitleiden.nl/en/science/l...

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Stephan Hacker @stephanhacker2.bsky.social · 30/08/2026

How time flies. Hard to believe that today is already our 7th wedding anniversary. I am incredibly happy and thankful that I married my best friend in the world, Ricarda. While there have certainly been tougher times, I could not imagine spending my life with anyone else. (1/2)

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Stephan Hacker @stephanhacker2.bsky.social · 27/08/2026

Interesting talk by Lu Cao at the #qBioLeiden kick-off meeting. She talk about her group's work into the application of deep learning in automated microscopy image analysis of cells.

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Stephan Hacker @stephanhacker2.bsky.social · 27/08/2026

Inspiring talk by Jeroen van Zon at the #qBioLeiden meeting. He gave exciting insights into their research on intestinal #organoids and their ability to automatically track individual cells over time and, thereby, monitor their differentiation. www.nature.com/articles/s41... #Science #Imaging

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Stephan Hacker @stephanhacker2.bsky.social · 27/08/2026

Interesting talk by Arjen Doelman at the #qBioLeiden kick-off meeting. He talked about the emergence of complex patterns in biology from the perspective of mathematics and how this contributes to understanding resilience in ecosystems. www.science.org/doi/full/10.... #Science #Ecology #patterns

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Stephan Hacker @stephanhacker2.bsky.social · 27/08/2026

A great talk by @kimmb1.bsky.social at the #qBioLeiden kick-off meeting. She talked about "Chemical tools to study biological immune processes" and gave exciting insights into the power of chemical tools to study biology on the example of NETosis. www.nature.com/articles/s42... #ChemSky #ChemBio

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Stephan Hacker @stephanhacker2.bsky.social · 27/08/2026

Erik Danen kicks-off the inaugural meeting of #qBioLeiden with an exciting lecture about the use of quantitative microscopy for #DrugDevelopment in the context of fibrosis and tumor immunology. www.nature.com/articles/s42... #DrugDiscovery #Microscopy CC: @led3hub.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 27/08/2026

Can we better understand complex biological systems in a quantitative fashion? This important question brings together many scientists from @leidenscience.bsky.social and the Leiden University Medical Center in the new network #qBioLeiden. (1/3) www.universiteitleiden.nl/quantitative...

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Stephan Hacker @stephanhacker2.bsky.social · 23/08/2026

Do you want to nominate a world-leading Chemical Biologist for a great award? The Richard Willstätter Prize for Chemical Biology that is awarded by the @dechema.bsky.social, DPhG , @gbmev.bsky.social and @gdch.de is now open for nominations until October 15th. www.dechema.de/chembio_priz... (1/2)

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Stephan Hacker @stephanhacker2.bsky.social · 23/07/2026

Congratulations to Daniel Merk on the @euromedchem.bsky.social Prize for a Young Medicinal Chemist or Chemical Biologist in Academia. Great to see @drglycoben.bsky.social and @lucalaraia.bsky.social as the most meritorious runners-ups. www.efmc.info/prizes #ChemSky #MedChem #ChemBio #Glycotime

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Stephan Hacker @stephanhacker2.bsky.social · 08/07/2026

Very much looking forward to the Symposium 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 in Cambridge (UK) on October 7th/8th! I am very happy to be part of an amazing lineup of speakers. Check out details and registration here: my.bps.ac.uk/events/detai... (1/2) #DrugDiscovery #ABPP #ChemBio #ChemSky

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Stephan Hacker @stephanhacker2.bsky.social · 25/06/2026

Inspiring @led3hub.bsky.social Lecture by @madelonmaurice.bsky.social. She talked about SureTACs as a modality for lysosomal degradation of membrane proteins by engaging membrane-bound E3 ligases using antibodies. worldwide.espacenet.com/patent/searc... #ChemSky #ChemBio #DrugDiscovery #TPD

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Stephan Hacker @stephanhacker2.bsky.social · 25/06/2026

How can you (avoid to) give a bad talk? A great Comment by Itai Yanai in Nature Reviews Cancer. It contains a lot of great pieces of advice, of which the following specifically resonate with me: (1/3) www.nature.com/articles/s41...

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Stephan Hacker @stephanhacker2.bsky.social · 19/06/2026

Exciting news that Ioana Ilie (@biosim-lab.bsky.social) was awarded the inaugural NextGenChem Award by NextGenChem@NL. Ioana's commitment to excellent research and teaching and her engagement to build and support a community of young group leaders in NL is truly exemplary. Huge Congratulations!

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Stephan Hacker @stephanhacker2.bsky.social · 16/06/2026

I am very happy that Yorick van Aalst represented our group with a great talk at the 3rd @led3hub.bsky.social PhD/postdoc symposium. He gave exciting insights into his project on mining the human proteome for druggable pockets. #ChemSky #ChemBio #DrugDiscovery #ProudPI

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Stephan Hacker @stephanhacker2.bsky.social · 11/06/2026

Great talk by Aukje Beers at the @led3hub.bsky.social Symposium. She talked about her work on new chemical tools for studying the function of the glycerophosphodiesterase GDE4 with important implications in pediatric neural cancers.

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Stephan Hacker @stephanhacker2.bsky.social · 11/06/2026

Johanna Erbani gave an exciting talk at the @led3hub.bsky.social Symposium. She talked about her work on better understanding lipid-laden macrophages and their involvement in tumorigenesis of glioblastomas. www.sciencedirect.com/science/arti...

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Stephan Hacker @stephanhacker2.bsky.social · 11/06/2026

Very happy that Menno Valk represented our group at the @led3hub.bsky.social Symposium with a Flash Talk on his project, in which he uses base editing to study the essentiality of individual amino acid residues in bacteria. Make sure to visit him at his poster to discuss his exciting project!

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