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Tobias Fellinger

@stats-tobby.bsky.social
54 followers 67 following 9 posts

Interested in biostats, R, regulatory science, clinical trials, time to event analysis, causal inference, ... he/him

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Reposted by Tobias Fellinger
European Medicines Agency @ema.europa.eu · 21/09/2026
EMA experts explore why we shouldn't focus on setting a requirement for a number of clinical trials. One pivotal trial, or two? What matters is generating evidence that addresses patients’ needs and supports a positive benefit–risk balance. Read the article: www.nature.com/articles/s41...
nature.com
Two trials or not two trials? That should not be the question - Nature Reviews Drug Discovery
Nature Reviews Drug Discovery - Two trials or not two trials? That should not be the question
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Reposted by Tobias Fellinger
Hadley Wickham @hadley.nz · 05/04/2026
Bill’s early work had an incredible influence on my career, especially his studies on perception and coplots. It’s so sad to hear that he passed away. May his memory be a blessing.
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Tobias Fellinger @stats-tobby.bsky.social · 18/01/2026
Did you know the FDA has gone full Bayesian? Better take in this blogpost, including intro to the context of guidance documents The guidance is quite good, but as stated in the blogpost, it leaves out where the FDA finds Bayesian methods acceptable. statmodeling.stat.columbia.edu/2026/01/15/f...
statmodeling.stat.columbia.edu
FDA guidance on Bayesian clinical trials | Statistical Modeling, Causal Inference, and Social Science
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Tobias Fellinger @stats-tobby.bsky.social · 14/01/2026
In other #regulatory news: FDA has released their draft guidance on #Bayesian Methods for public consultation. This guidance has been under development for quite some time and is a good overview about the regulatory thinking / interpretation of Bayesian methods. www.fda.gov/media/190505...
fda.gov
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Tobias Fellinger @stats-tobby.bsky.social · 14/01/2026
In joint work with #EMA and #FDA colleagues we wrote down 10 guiding principles of good #AI practices in #drugdevelopment that are now finally published 🎉 They are quite general and hopefully universally agreed upon, detailed guidance will follow. www.fda.gov/media/189581... #pharma #regulatory
fda.gov
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Reposted by Tobias Fellinger
Jeremy Labrecque @jeremylabrecque.bsky.social · 29/07/2025
Should statistical software that estimates causal effects also tell you the causal assumptions under which that estimate can be interpreted as causal? I don't know but my PhD student Maurice Korf has some thoughts (and software) to get the conversation going: academic.oup.com/ije/article/...
academic.oup.com
Causal clarity in statistical software
Imagine running a simple regression in any statistical software of choice—but this time, you only get a point estimate of the regression coefficient. There
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Reposted by Tobias Fellinger
Journal of Clinical Epidemiology @jclinepi.bsky.social · 18/09/2025
The distinction between causal, predictive, and descriptive research—there is still room for improvement - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
jclinepi.com
The distinction between causal, predictive, and descriptive research—there is still room for improvement
It has been proposed that medical research questions can be categorised into three classes: causal, predictive, and descriptive. This distinction was proposed to encourage researchers to think clearly...
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Reposted by Tobias Fellinger
Georg Heinze @georgheinze.bsky.social · 18/09/2025
Great experience with a novel format of an invited session of #stratos TG2 @biometricsociety.bsky.social Austro-Swiss region meeting (ROeS 2025 Graz) (1/n)
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Tobias Fellinger @stats-tobby.bsky.social · 20/02/2025
Thanks to all co-authors! (Of who only @poschm.bsky.social is present on bluesky If I'm not mistaken.)
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Tobias Fellinger @stats-tobby.bsky.social · 20/02/2025
doi.org/10.1002/sim.... Our paper "A Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards" got published today 🎉 We describe commonly used methods, and compare their performance in a simulation study across different scenarios.
doi.org
A Comparison of Statistical Methods for Time‐To‐Event Analyses in Randomized Controlled Trials Under Non‐Proportional Hazards
While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best inferential approach under non-proportional hazar...
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Reposted by Tobias Fellinger
Carl T. Bergstrom @carlbergstrom.com · 28/01/2025
An LLM "creates textual claims, and then predicts the citations that might be associated with similar text. Obviously, this practice violates all norms of scholarly citation. At best, LLMs gesticulate toward the shoulders of giants." Bender, West, and I contributed to this pro/con piece in PNAS.
pnas.org
How should the advancement of large language models affect the practice of science? | PNAS
Large language models (LLMs) are being increasingly incorporated into scientific workflows. However, we have yet to fully grasp the implications of...
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Tobias Fellinger @stats-tobby.bsky.social · 27/01/2025
Paper finally acxepted after 3 years of work on the project with a large consortium 🎉 I'll post a link, when it's published
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Reposted by Tobias Fellinger
AGES – Österr. Agentur für Gesundheit und Ernährungssicherheit @ages.at · 10/01/2025
Hallo, Bluesky! Wir sind neu hier und freuen uns, Teil dieser Community zu werden! Freut euch auf spannende Inhalte rund um die Gesundheit von Mensch, Tier, Pflanze und Umwelt. Sagt "Hi" in den Kommentaren und folgt uns für mehr! 💛 www.ages.at
Hallo, Bluesky!

Folge uns für mehr! @ages.at

Instagram: ages_news
Facebook: AGES - Österreichische Agentur für Gesundheit und Ernährungssicherheit
LinkedIn: AGES - Österreichische Agentur für Gesundheit und Ernährungssicherheit
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Tobias Fellinger @stats-tobby.bsky.social · 13/01/2025
Also imagine the work of typesetting formulae before LaTeX, ...
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Tobias Fellinger @stats-tobby.bsky.social · 13/01/2025
I have the greatest respect for graphics in scientific papers before computer graphics and even pen plotters were a common thing. Just beautiful 😍
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Tobias Fellinger @stats-tobby.bsky.social · 11/12/2024
Hi bluesky 👋 Hope there's some biostats people here, all the R people are also on mastodon but biostats wise it's been a bit lonely since leaving twitter
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Reposted by Tobias Fellinger
Maarten van Smeden @maartenvsmeden.bsky.social · 11/12/2024
Key question to consider before submitting your paper on the development and validation of your new clinical prediction model is: WHERE IS THE MODEL????
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