iiinova — where your digital self keeps evolving

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Lopes_Lab @lopeslab.bsky.social · 01/04/2026

Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

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Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 10/03/2026

Pour les francophones : voici un article de communication du CNRS sur notre publication récente dans NSMB, avec @ahellab.bsky.social, @spartelab.bsky.social, et al, sur la structure et le mécanisme des sirtuines FAM118 ('SIRal') - de véritables « fossiles » apparentés aux protéines bactériennes.

inc.cnrs.fr

Des molécules immunitaires héritées des bactéries identifiées dans les cellules humaines

Une équipe franco-britannique de scientifiques a exploré deux protéines humaines récemment identifiées comme enzymes immunitaires.

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Institut de Génétique & Développement de Rennes @igdrennes.bsky.social · 05/03/2026

🔬 3ᵉ Symposium en Sciences de la Vie – Appel à communications ouvert ! Un rendez-vous incontournable pour présenter vos travaux et échanger avec des chercheurs expérimentés. 👉 Pour soumettre un résumé (Date limite : 3 avril) et vous inscrire, rendez-vous igdr-phd-symp26.sciencesconf.org?lang=en

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SP@RTE @spartelab.bsky.social · 14/02/2026

PhD in Rennes! Study how OGG1 repairs oxidative DNA damage using advanced microscopy. Join Sébastien Huet’s team at IGDR (Oct 2026). Master’s in cell biology/biophysics? Apply: sebastien.huet@univ-rennes.fr #PhD #CancerResearch #Microscopy

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Hélène Bouvrais @bouvraish.bsky.social · 03/01/2025

We are offering a 24-month post-doctoral position in our team, based in Rennes, France (@IGDR, @cedre-lab). Looking for a highly motivated researcher with expertise in deep learning and image analysis. emploi.cnrs.fr/Offres/CDD/U... #PostDoc #DeepLearning #ImageAnalysis #ResearchOpportunity

emploi.cnrs.fr

Portail Emploi CNRS - Offre d'emploi - Chercheur post-doctoral (H/F) : utilisation de l’apprentissage profond et de la simulation pour extraire les paramètres géométriques de filaments dans des imag...

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SP@RTE @spartelab.bsky.social · 12/02/2026

In this study, we reveal that OGG1’s association with DNA during lesion searching involves local DNA distortion, promoting base unstacking. This process is tightly regulated by conserved amino acids encircling the double helix, ensuring stable binding without compromising rapid scanning.

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SP@RTE @spartelab.bsky.social · 23/01/2026

"Exciting opportunity! Our team is offering two PhD projects for this doctoral competition. Explore our innovative research topics and join us in pushing scientific boundaries. Applications open—don’t miss out! #PhD #Research #JoinUs"

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SP@RTE @spartelab.bsky.social · 18/12/2025

The IGDR @igdrennes.bsky.social and the Faculty of Sciences at the University of Rennes announce an opening for a University Professor position in CNU Section 65 "Genetic and Epigenetic Regulations" with the opportunity to join our team @spartelab.bsky.social #PU #CNU65.

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SP@RTE @spartelab.bsky.social · 18/12/2025

L'IGDR @igdrennes.bsky.social et la Faculté des Sciences de l'Université de Rennes annoncent l'ouverture d'un poste de Professeur des Universités en section CNU 65 "Régulations génétiques et épigénétiques" avec l'opportunité de rejoindre notre équipe @spartelab.bsky.social #PU #CNU65

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Nicolas Bigot @nicolab.bsky.social · 18/12/2025

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Nicolas Bigot @nicolab.bsky.social · 18/12/2025

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Ignacio Izeddin @izeddinresearch.bsky.social · 13/10/2025

SPT of DNA repair proteins after cell irradiation by Ashli Kobayashi @asaki-kobayashi.bsky.social and Romane Riou. Setup by Abbelight @abbelight.bsky.social and irradiator by Errol Laser @errol-laser.bsky.social. Look at that recruitment! #Mifobio2025 @gdrimabio.bsky.social

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ahellab.bsky.social @ahellab.bsky.social · 24/05/2025

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

my.corehr.com

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ahellab.bsky.social @ahellab.bsky.social · 06/06/2025

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecru...

my.corehr.com

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Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 05/06/2025

Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...

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SP@RTE @spartelab.bsky.social · 27/05/2025

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

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Institut de Génétique & Développement de Rennes @igdrennes.bsky.social · 17/03/2025

#ScientificResult | A collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM discovers how SIAH1 polymerization could improve the clearing of protein aggregates involved in certain neurodegenerative diseases. igdr.univ-rennes.fr/en/proteins-... pubmed.ncbi.nlm.nih.gov/39910688/

Team building among proteins: how oligomerisation of SIAH1 promotes its ubiquitin ligase activity.

By describing how SIAH1 forms polymers within cells, a collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM, improves our understanding of the mechanisms by which protein aggregates involved in certain neurodegenerative diseases get cleared by the cells.

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Institut de Génétique & Développement de Rennes @igdrennes.bsky.social · 21/03/2025

📢Are you planning to do a #PhD in #Biology? There's still a month to apply at #IGDR PhD call! Apply before April 21st, 1:00 pm 7 to 9 positions ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program cc @cnrs-bretagneloire.bsky.social @insermgrandouest.bsky.social @rennesuniv.bsky.social

IGDR PhD Call | Exploring living for tomorrow's health

Applications up to april 21st 2025 13:00 am

This year, about 7 to 9 positions will be available to conduct a PhD project within one of the teams of the IGDR on topics encompassing our two research axes "Genetics, Ganomics and Cancer" and "Cell Biology, Development and Biophysics".

Apply online now
https://igdr.univ-rennes.fr

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Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 06/02/2025

Here is a link to the article: onlinelibrary.wiley.com/share/author... We're very happy to see it published in a society journal, The FEBS J. It's another great collaboration with the team from Rennes led by Sébastien Huet @spartelab.bsky.social . Thanks to @ercresearch.bsky.social for funding.

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Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 06/02/2025

Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.

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Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 06/02/2025

This is a cover design that wasn't accepted, showing SIAH1 multimers on top of cells (SIAH1 red, actin green). We were not able to visualise SIAH1 chains in vitro, as we could only purify N- or C-term halves of SIAH1 separately: the blue chains are made from combined dimeric structures of each half.

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SP@RTE @spartelab.bsky.social · 03/12/2024

What better occasion for our first post on Bluesky than this? Congratulations to Dr. Eva Pinto for successfully defending her thesis, "Study of ADP-ribose-dependent chromatin remodeling processes occurring at early stages of the DNA damage response." 🧬🔬

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