iiinova — where your digital self keeps evolving

Reposted by Sonja Blasche

Simone Mozzachiodi @simonemozzachiodi.bsky.social · 10/03/2026

Happy to share our review on non-model microbes and microbial communities in biotechnology! With @sonjablasche.bsky.social @indraroux.bsky.social @kiranrpatil.bsky.social see below 👇🏼

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Reposted by Sonja Blasche

Stephan Kamrad @skamrad.bsky.social · 15/05/2025

Check out our new preprint! We systematically map proteomic and metabolomic interactions between >100 pairs of gut bacteria, detecting metabolic interactions and functionally-related clusters of proteins. www.biorxiv.org/content/10.1... @kiranrpatil.bsky.social

biorxiv.org

Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism

Species in microbial communities must respond to the presence of others to stave off resource competition or to capitalise on new resources that may become available due to additional metabolic activi...

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Reposted by Sonja Blasche

Engineering Biology Interdisciplinary Research Centre @engbioirc.bsky.social · 15/05/2025

Join us at CafeSynthetique on 2 June with talks from Wes Roberston @mrclmb.bsky.social 'Synthetic genomics for microbiome reprogramming' and SonjaBlasche @sonjablasche.bsky.social @mrc-tu.bsky.social 'milk kefir🥛 in fermented food applications' Register here 🦠👉 www.tickettailor.com/events/engin...

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Sonja Blasche @sonjablasche.bsky.social · 04/04/2025

Our findings highlight widespread combination effects between commonly co-consumed chemicals in gut bacteria. A collaborative effort with Vinita, @noniberistain.bsky.social @indraroux.bsky.social @skamrad.bsky.social @rbradley.bsky.social @guan06rui.bsky.social @itsbinir.bsky.social and more!(5/5)

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Sonja Blasche @sonjablasche.bsky.social · 04/04/2025

Proteomic, metabolomic, and genetic analyses revealed altered small molecule transport underlying this sweetener-drug synergy. This combination also modulated metabolism in a synthetic gut bacterial community, increasing toxicity and altering the secretion of cytokines in human cells. (4/5)

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Sonja Blasche @sonjablasche.bsky.social · 04/04/2025

We identified over 100 synergistic and antagonistic growth effects upon co-exposure. For example, isosteviol + duloxetine synergistically inhibited Roseburia intestinalis, a bacterium associated with glucose homeostasis, and Parabacteroides merdae, a prevalent commensal. (3/5)

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Sonja Blasche @sonjablasche.bsky.social · 04/04/2025

We tested 39 commercially used sweeteners for their effects on 25 gut-associated bacterial strains. To uncover combinatorial effects, we combined them with four commonly consumed compounds: the sweetener advantame, caffeine, vanillin, and the antidepressant duloxetine. (2/5)

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