Gamma-aminobutyric acid (GABA) is a neurotransmitter that inhibits neuronal excitability and also affects mucosal function and gut motility. Importantly, while the gut microbiome is a known source of ...

Interactions between the human body and gut microbes are crucial for health and disease. We present the Virtual Colon, an extension of the individual-based microbiome modeling approach BacArena that m...

This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes

Holobionts are complex communities comprising a host and its diverse microbiota. Their intricate relationships are crucial for biological processes like nutrient uptake, immune function, and environme...

In this Perspective, Mattson discusses that the beneficial effects of intermittent fasting (IF) are mediated by cyclic metabolic switching between ketogenic (fasting) and non-ketogenic (fed) states and that this explains the added health benefits of IF over caloric restriction and ketogenic diets.

In a large multi-ethnic Asian cohort, associations between over 1,000 plasma metabolites and specific foods and beverages are made. These diet–metabolite relationships were used to accurately predict clinical phenotypes such as diabetes and hypertension.

Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the tra...

Host-microbe interactions play an integral role in the function and survival of eukaryotes, influencing various processes ranging from metabolism to i…

Aging-related cognitive decline is associated with changes across different tissues and the gut microbiome, including dysfunction of the gut-brain axis. However, only few studies have linked multi-org...

Communications Biology - A metabolic modeling approach reveals druggable host cell pathways essential for viral replication across various viruses with minimal cytotoxicity. These findings...

A map of microbiome–metabolome dynamics in people with type 2 diabetes identifies over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered...

A multi-omics approach reveals host–microbiome interactions in aging in mice.