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Frank Hause

@fhause.bsky.social
649 followers 1.2K following 197 posts

PhD student at Institute of Molecular Medicine at Martin Luther University Halle-Wittenberg (Hüttelmaier lab) Molecular Biology | Complex Systems | Data Science | Bayesianism | Ordinary Language Theory | Liberal Democracy

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Reposted by Frank Hause
CENTRA @centrabrowser.bsky.social · 04/02/2026
👉 ngs-info.medizin.uni-halle.de/shiny/CENTRA/ 🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
ngs-info.medizin.uni-halle.de
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
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CENTRA @centrabrowser.bsky.social · 04/02/2026
We’d love to hear your thoughts. Tried CENTRA yet? Feedback, bugs, ideas, or a module that completely surprised you? Tell us, we’re already shaping the next updates. 💬 DMs are open, or visit ngs-info.medizin.uni-halle.de/shiny/CENTRA/ for more contact options.
ngs-info.medizin.uni-halle.de
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
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Reposted by Frank Hause
CENTRA @centrabrowser.bsky.social · 31/01/2026
👉 ngs-info.medizin.uni-halle.de/shiny/CENTRA/ 🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
ngs-info.medizin.uni-halle.de
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
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Reposted by Frank Hause
CENTRA @centrabrowser.bsky.social · 31/01/2026
Thinking about using CENTRA for functional exploration? The browser comes with built-in functions to: 📚 parse gene metrics 🔍 generate ready-to-publish graphs 🧠 explore module functions across all networks Everything is fully accessible without any account or login.
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CENTRA @centrabrowser.bsky.social · 28/01/2026
🔀 CENTRA assesses the variance of betweenness to see how stable a gene’s bridging role really is. 📉 By randomly rewiring our networks we control for underrepresented genes in the dataset. 🛡️ What remains are genuine, robust information brokers or hidden functional master regulators.
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Reposted by Frank Hause
CENTRA @centrabrowser.bsky.social · 25/01/2026
👉 ngs-info.medizin.uni-halle.de/shiny/CENTRA/ 🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
ngs-info.medizin.uni-halle.de
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
011
Reposted by Frank Hause
CENTRA @centrabrowser.bsky.social · 25/01/2026
🧠 CENTRA uses Latent Dirichlet Allocation (LDA) to cluster gene sets by their semantic content. 🗂️ Each cluster becomes a distinct biological topic. 🕸️ This transforms unstructured text into functional gene networks.
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Reposted by Frank Hause
CENTRA @centrabrowser.bsky.social · 22/01/2026
Each gene in CENTRA comes with its own radar plot visualizing key topological properties: 📡 Centrality 🌿 Local fractality 🛡️ Robustness Perfect for comparing genes across different biomedical topics.
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CENTRA @centrabrowser.bsky.social · 19/01/2026
CENTRA’s topics span a wide biological landscape, including: 🧠 Neurodevelopment 🔬 DNA damage response 🦠 Immune regulation 💥 Apoptosis 🧫 Cancer metabolism …besides many others. Each topic forms its own network with distinct functional hubs.
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CENTRA @centrabrowser.bsky.social · 16/01/2026
🧩 CENTRA identifies modules using Louvain clustering. 🔍 Each module is tested for functional coherence via Overrepresentation Analysis. 📊 The resulting modules often align with coordinated biological processes and pathways.
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CENTRA @centrabrowser.bsky.social · 13/01/2026
🌿 Some genes reveal structure not by connections alone, but by how complex their local neighborhood is. CENTRA uses Local Fractal Dimension to capture this, a measure of how dense the surroundings of a gene become in the network. ✨ High LFD can hint at elevated information density.
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CENTRA @centrabrowser.bsky.social · 12/01/2026
⭐ Some genes stand out because of who they’re connected to. CENTRA uses eigenvector centrality to identify these influence hubs, genes linked to other highly connected players across the network. ✨ High eigenvector values can hint at strong regulatory relevance.
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CENTRA @centrabrowser.bsky.social · 11/01/2026
🔀 Some genes quietly sit at the crossroads of biological information flow. CENTRA uses betweenness centrality to find these hidden mediators, genes that bridge modules and shape how information moves through a network. ✨ High betweenness can hint at regulatory leverage.
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CENTRA @centrabrowser.bsky.social · 10/01/2026
How do we define a key gene in a network? CENTRA uses multiple centrality measures: 🔹 Betweenness 🔹 Eigenvector 🔹 Local Fractal Dimension These combine to reveal functional importance across contexts.
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CENTRA @centrabrowser.bsky.social · 09/01/2026
CENTRA is available as interactive browser app: 🧭 Explore topic-specific networks 🔍 Search genes or terms 🌐 Visualize modules, metrics, enrichments
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CENTRA @centrabrowser.bsky.social · 07/01/2026
🚨 Our CENTRA paper is out in NAR Genomics and Bioinformatics! CENTRA shows how centrality and fractal geometry uncover functional master regulators across biological networks. You can explore everything instantly, completely open access. doi.org/10.1093/narg...
doi.org
Validate User
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Oded Rechavi @odedrechavi.bsky.social · 08/11/2025
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
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Oded Rechavi @odedrechavi.bsky.social · 06/11/2025
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
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Ewan Birney @ewanbirney.bsky.social · 10/10/2025
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com
Staff Scientist
About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...
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Ustinische Sümpfe @ustinoff.eurosky.social · 08/10/2025
Auch hier ist nicht drin was drauf steht. Verbieten!
Weinflasche kröver Nacktarsch
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Andrea Sinz 🧪 @sinzandrea.bsky.social · 29/08/2025
🚨 Two manuscripts accepted at Nature Communications within one week!🎉 Both papers deal with GPCRs. Thank you, Anette Kaiser and Tobi Langenhan, the wonderful collaborations! 😀 More details will follow. @unihalle.bsky.social @unileipzig.bsky.social
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Andrea Sinz 🧪 @sinzandrea.bsky.social · 05/10/2025
🧪 And this is the second Nature Communications @natcomms.nature.com paper where we contributed: www.nature.com/articles/s41... @academic-chatter.bsky.social @academicsky.org #teammassspec @unileipzig.bsky.social @unihalle.bsky.social
nature.com
Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors - Nature Communications
The GAIN domain of adhesion G protein-coupled receptors, a class of biological mechanosensors, was thought to be sufficient for its self-cleavage. Here, the authors show that the event also depends on the seven-transmembrane region of the receptors.
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Oded Rechavi @odedrechavi.bsky.social · 03/10/2025
Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇
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Frank Hause @fhause.bsky.social · 02/10/2025
The gentle rays of morning hint at summer’s end.
Foggy morning view of a cable-stayed bridge with a tall central pylon and multiple suspension cables, silhouetted against the rising sun shining through the mist, with tram lines and street lamps in the foreground.
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The New Yorker @newyorker.com · 18/09/2025
D. T. Max writes about the slow becoming of one of the world’s most unusual—and soon to be tallest—churches: the Sagrada Família.
newyorker.com
Is the Sagrada Família a Masterpiece or Kitsch?
In the century since Antoni Gaudí died, his wild design has been obsessively realized, creating the world’s tallest church—and an endlessly debated icon.
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Andrea Sinz 🧪 @sinzandrea.bsky.social · 13/09/2025
Our manuscript "Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport" has just been accepted at Nature Communications!🎉🎉 I feel truly honored to be part of this work that was headed by Panos Kastritis and Gary Sawers.More information to follow! @unihalle.bsky.social #Academicsky
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Conference on Complex Systems @css-conference.bsky.social · 05/09/2025
Thank you Prof. Mirta Galesic (University of Vienna and Santa Fe Institute) for the inspiring talk “Collective moderation of public discourse” at CCS 2025!
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Conference on Complex Systems @css-conference.bsky.social · 05/09/2025
Hiroki Sayama announced that CCS2026 will be held in Binghamton, USA — see you there! 🇺🇸 #CCS2026
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Conference on Complex Systems @css-conference.bsky.social · 03/09/2025
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Oded Rechavi @odedrechavi.bsky.social · 03/09/2025
"It's not the end of the world, let's just send it to another journal"
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Frank Hause @fhause.bsky.social · 03/09/2025
What reading through the reviewer comments feels like. #AcademicSky 🧪
A Baroque-style painting showing a man in a brown monastic robe looking upward toward three angels who are holding up a large golden tablet inscribed with ornate sacred letters.
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Hannah Shelley, MLIS (Maggots, Lycanthropes & Ice Skeletons) @hannahshelley.site · 13/08/2025
Since search is dead, how soon do you think Google Scholar is headed for the Google Graveyard? I'm betting it's soon, and academia is NOT prepared
hannahshelley.neocities.org
Google Scholar Is Doomed
Academia built entire careers on a free Google service with zero guarantees. What could go wrong?
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Oded Rechavi @odedrechavi.bsky.social · 26/08/2025
Editor searching reviewers in August
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Frank Hause @fhause.bsky.social · 04/08/2025
Well … www.reuters.com/world/un-rep...
reuters.com
UN report finds United Nations reports are not widely read
A United Nations report seeking ways to improve efficiency and cut costs has revealed: U.N. reports are not widely read.
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Frank Hause @fhause.bsky.social · 23/07/2025
Nothing beats a Jet2 holiday... except, maybe, finding a high-quality set of hyperparameters for your autoencoder. 🧪🧬🖥️ #AcademicSky
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Frank Hause @fhause.bsky.social · 18/07/2025
Four weeks of heavy science — demanding but productive. Now I’m really looking forward to the weekend and recharging around the people who matter most.
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Frank Hause @fhause.bsky.social · 10/07/2025
What twisted path led me here, where every progress::progress_bar in my scripts ticks up longer than it ticks down? Here is neither forgiveness nor convergence. 🧪🧬🖥️ #AcademicSky
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Frank Hause @fhause.bsky.social · 07/07/2025
Finally, the draft is submitted. Starting tomorrow, I can focus on new goals — at least until the manuscript decision arrives. 🧪 #AcademicSky
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Oded Rechavi @odedrechavi.bsky.social · 07/07/2025
Pending editorial decision
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Frank Hause @fhause.bsky.social · 06/07/2025
Whoever designed manuscript submission portals for scientific papers clearly hated people — and someone else looked at it and said: “Brilliant. Let’s make every scientist suffer with this.” 🧪 #AcademicSky
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Amrei Bahr @amreibahr.bsky.social · 06/07/2025
Der Wels ist alles, was der Fall ist.
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Frank Hause @fhause.bsky.social · 05/07/2025
Science doesn’t take weekends. It’s Saturday, I’m sipping coffee, and running network fractality analyses like that’s a normal way to unwind. Which, frankly, it is. 🧪 #AcademicSky
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Frank Hause @fhause.bsky.social · 03/07/2025
Spent 1.5 hours and 2 glasses of wine perfecting the color palette of my scientific poster. Now questioning if content is even necessary. 🧪 #AcademicSky
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typdertweetet @typdertweetet.de · 02/07/2025
... und trotzdem leisten wir uns sehr, sehr teure Clowns.
Artikel-Screenshot von Spiegel Politik. Ein Foto von Fritze Merz bei Maischberger. Titel: "Merz über Regenbogenflagge: »Der Bundestag ist kein Zirkuszelt«".
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Frank Hause @fhause.bsky.social · 02/07/2025
Almost 40°C outside make a pretty convincing argument to stay in the (air-conditioned) lab and help advance science 🧪 #AcademicSky
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Frank Hause @fhause.bsky.social · 30/06/2025
Uploading manuscripts breaks me every time — takes two seconds to spot the first flaw I missed after weeks of staring at it. 🧪 #AcademicSky
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Andrea Sinz 🧪 @sinzandrea.bsky.social · 23/06/2025
🧪Fantastic work 👍🎉🎉 by @claudio-iacobucci.bsky.social and his group how cross-linking MS #XL-MS can help obtaining information on secondary structures in proteins. So proud that Claudio was a Humboldt fellow @humboldt-foundation.de in my lab in Halle @unihalle.bsky.social several years ago!😊
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Frank Hause @fhause.bsky.social · 16/06/2025
Ein Ministerpräsident, der bei einem drohenden AfD-Sieg laut über Auswanderung nachdenkt, statt ein Verbotsverfahren zu fordern, hat sein Amt geistig bereits niedergelegt. Resignation ist keine Haltung! www.spiegel.de/politik/deut...
spiegel.de
Ministerpräsident Haseloff würde bei AfD-Sieg über Umzug nachdenken
Reiner Haseloff wäre bei einer Machtübernahme der AfD in Sachsen-Anhalt bereit, seine Heimat zu verlassen. Der langjährige Ministerpräsident fürchtet in diesem Fall eine »unerträgliche Atmosphäre«.
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Andrea Sinz 🧪 @sinzandrea.bsky.social · 12/06/2025
Our new tiny MALDI-8030 Easy Care has just arrived…first Shimadzu MS in my life…😜 We will use it for biotyping 🦠 and for teaching our pharmacy students. 💊🧬🧪 @unihalle.bsky.social #AcademicSky #ChemSky
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