iiinova — where your digital self keeps evolving

Simon Schultz @simonschultz.bsky.social · 06/02/2026

On my way back from Glasgow after a very interesting day talking to the Psychology and Neuroscience crowd there.

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Simon Schultz @simonschultz.bsky.social · 04/02/2026

An updated version of the following paper is now available on bioRxiv: Early spatial and contextual coding deficits in hippocampal CA1 precede performance decline in an Alzheimer's disease model. Yimei Li, Mary Ann Go, Hualong Zhang, Simon R Schultz. www.biorxiv.org/content/10.1...

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Simon Schultz @simonschultz.bsky.social · 23/11/2025

This might have been a better summary image. Vessels in red, Methoxy-X04 plaques in magenta.

Simon Schultz @simonschultz.bsky.social · 23/11/2025

An update of one of our papers has been posted to biorxiv. Stas, Yang, Schultz and Go, "Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease". www.biorxiv.org/content/10.1...

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Simon Schultz @simonschultz.bsky.social · 20/09/2025

Nice. Here’s my little harvest of the morning.

Simon Schultz @simonschultz.bsky.social · 16/08/2025

We demonstrate the use of three-photon microscopy to track changes in vascular structure related to amyloid plaque formation in the APP NL-G-F knock-in model of Alzheimer's Disease.

Simon Schultz @simonschultz.bsky.social · 16/08/2025

New preprint from the lab. Eline Stas et al, "Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease". www.biorxiv.org/content/10.1...

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Simon Schultz @simonschultz.bsky.social · 15/06/2025

The second of the hippocampus-inspired paintings by @anjiolina.bsky.social just came back from framing. I’m very happy with how it turned out.

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Simon Schultz @simonschultz.bsky.social · 11/06/2025

There is a beautiful movie but Bluesky won't show it bc of the aspect ratio, so instead I just show the first frame above. However, here is another snippet - this time simultaneous imaging of 4 different cortical regions at a depth of 520 µm at 7 Hz. All in head-fixed mice exploring a 2D chamber.

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Simon Schultz @simonschultz.bsky.social · 11/06/2025

This paper presents ULTRA, a new microscope platform which can image a field of view over 7mm diameter and at depths up to 900 µm into cortex. We can image ~10,000 neurons simultaneously at high SNR, and at the same time have the spatial resolution to capture dendritic spines. 1 frame of a movie:

Simon Schultz @simonschultz.bsky.social · 24/05/2025

This is the other hippocampal painting by @anjiolina.bsky.social - I am taking it down to have it framed now. I really like this one. (As I mentioned before, she does neuro-inspired artworks on commission; if you are interested, contact her directly here or via instagram @neuronakaya).

A slightly abstract painting of the hippocampus by artist Anjiolina Nakaya

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Simon Schultz @simonschultz.bsky.social · 16/05/2025

We need to start them on it younger.

Simon Schultz @simonschultz.bsky.social · 27/02/2025

You may try to escape, Mr Snowy, but you won’t get far.

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Simon Schultz @simonschultz.bsky.social · 25/02/2025

Love the BrainBox t-shirt ブレインボックス

Simon Schultz @simonschultz.bsky.social · 21/02/2025

Climbing Hachiojisan with Kazuo Kitamura and his lab. #kabhike

View of Mt Fuji with Kōfu in the foreground.

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Simon Schultz @simonschultz.bsky.social · 07/02/2025

I want to thank especially first author Yimei Li for the huge amount of work she carried out over the 4 years of her PhD (including the pandemic), establishing a head-fixed spatial working memory task that can be used with 2P imaging. She was a truly wonderful student, and a great scientist.

A typical field of view image under the two photon microscope, with the fluorescence time series from 10 neurons shown.

Old AD mice fail to learn the task - young AD mice and old WT mice are both slightly slower at doing so than controls.

Spatial information rates in this task are reduced by both age and AD genotype.

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Simon Schultz @simonschultz.bsky.social · 07/02/2025

We trained head-fixed mice on a fig-8 spatial alternation task. Learning performance was sensitive to age and genototype, with 5xFAD mice showing impairment. Spatial coding and place cell stability disruptions preceded behav. deficits. Splitter cell degradation correlated with poor task performance.

Mouse performing an alternation memory task

Simon Schultz @simonschultz.bsky.social · 01/02/2025

@nicolecrust.bsky.social I randomly came across this photo of you at my wedding... some time ago now.

Nicole Rust very elegantly holding a cup of tea

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Simon Schultz @simonschultz.bsky.social · 12/01/2025

Hippocampus inspired painting by artist Anjiolina Nakaya @anjiolina.bsky.social. I understand that she takes commissions, and is painting to raise money to pay her way through uni. #neuroart

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Simon Schultz @simonschultz.bsky.social · 23/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 20.

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Simon Schultz @simonschultz.bsky.social · 22/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 19.

Simon Schultz @simonschultz.bsky.social · 19/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 18.

Simon Schultz @simonschultz.bsky.social · 18/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 17.

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Simon Schultz @simonschultz.bsky.social · 17/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 16.

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Simon Schultz @simonschultz.bsky.social · 16/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 15.

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Simon Schultz @simonschultz.bsky.social · 15/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 14.

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Simon Schultz @simonschultz.bsky.social · 14/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 13.

Simon Schultz @simonschultz.bsky.social · 13/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 12.

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Simon Schultz @simonschultz.bsky.social · 12/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 11.

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Simon Schultz @simonschultz.bsky.social · 09/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 10.

Cover of Tim Flannery book “throwim way leg”

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Simon Schultz @simonschultz.bsky.social · 08/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 9.

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Simon Schultz @simonschultz.bsky.social · 07/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 8.

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Simon Schultz @simonschultz.bsky.social · 06/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 7.

At the mountains of madness, book cover.

Simon Schultz @simonschultz.bsky.social · 05/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 6.

Simon Schultz @simonschultz.bsky.social · 05/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 5.

Simon Schultz @simonschultz.bsky.social · 03/12/2024

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 4.