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Shweta Tyagi @shwetatyagi.bsky.social · 04/09/2026

Excited to share our new preprint! 🧬 www.biorxiv.org/content/10.6... Fantastic work 👏 by Kaisar Lone uncovers a connection between KMT2A, PCAF and rDNA transcription, revealing another layer of regulation of ribosomal DNA. #Chromatin #Transcription #RNApol #rDNA #KMT2A #ncRNA

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Shweta Tyagi @shwetatyagi.bsky.social · 16/05/2026

Is #RNAPolI responsive to #GeneRegulation by H3K4 KMTs? Read how #KMT2F/SETD1A regulates #Chromatin in the #Nucleolus to promote #rRNA #Transcription doi.org/10.1371/jour... Fantastic study by PhD student Kaisar 👏 🥳 #Epigenetics @plosbiology.org @bric-cdfd.bsky.social

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Reposted by Shweta Tyagi

PLOS Biology @plosbiology.org · 11/05/2026

What is the role of active #transcription mark H3K4me3 in #rDNA gene regulation? @shwetatyagi.bsky.social &co show that #histone methyltransferase KMT2F promotes preinitiation complex formation & transcriptional activation of rDNA genes by RNA polymerase I @plosbiology.org 🧪 plos.io/48MSRwh

RNA Pol I machinery interacts with KMTs. Schematic showing the arrangement of RNA Pol I holo complex with its associated proteins. RNA Pol I has 14 subunits, out of which 7 are shared with Pol II and Pol III while the rest are unique to Pol I. Unique subunits are shown in color. RPA190, RPA116 and RPA12 form the catalytic core of the RNA Pol I, whereas RPA34, RPA43 and RPA49 are classified as the peripheral subunits. UBF prepares the rDNA promoter for RNA Pol I docking. This is followed by binding of the SL1 complex, which consists of TATA binding protein (TBP) and four transcription-associated factors (TAFs) TAF1A/TAFI48, TAF1B/TAFI63, TAF1C/TAFI110 and TAF1D/TAFI41. hRRN3 identifies and recruits free RNA Pol I to the rRNA gene promoter that is already bound by UBF and SL1 complex.

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Shweta Tyagi @shwetatyagi.bsky.social · 12/02/2026

📢Faculty Recruitment CDFD invites applications for Faculty position Apply here: recruitment.cdfd.org.in #FacultyPositions #AcademicJobs #LifeSciences #CDFD #ScienceCareers #Hiring

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Reposted by Shweta Tyagi

Journal of Cell Science @jcellsci.bsky.social · 10/12/2025

New JCS snapshot - The MLL/WDR5 complex promotes midbody recruitment of KIF2C for microtubule depolymerisation & furrow initiation during cytokinesis Avishek Kataria presents the key findings from their recent JCS paper with @shwetatyagi.bsky.social & team. journals.biologists.com/jcs/article/...

youtu.be

JCS snapshot: The MLL/WDR5 complex promotes midbody recruitment of KIF2C

YouTube video by The Company of Biologists

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Shweta Tyagi @shwetatyagi.bsky.social · 14/11/2025

Also, check out special issue call for papers!!

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Reposted by Shweta Tyagi

Journal of Cell Science @jcellsci.bsky.social · 24/10/2025

Avishek Kataria, Shweta Tyagi @shwetatyagi.bsky.social and colleagues @bric-cdfd.bsky.social find that the MLL/WDR5 complex promotes midbody recruitment of KIF2C for microtubule depolymerisation & furrow initiation during cytokinesis. journals.biologists.com/jcs/article/...

Figure showing that MT depolymerization activity of KIF2C plays role in cytokinesis.

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Reposted by Shweta Tyagi

BRIC - CDFD @bric-cdfd.bsky.social · 17/10/2025

New paper published in @jcellsci.bsky.social from the lab of Dr. @shwetatyagi.bsky.social exploring a new role of MLL/WDR5 complex in cytokinesis. Read more: doi.org/10.1242/jcs.... #MLL #midbodyformation #furrowinitiation

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Reposted by Shweta Tyagi

BRIC - CDFD @bric-cdfd.bsky.social · 21/10/2025

Have you applied for the CDFD PhD program, beginning Jan. 2026? If not, hurry, the last date is 28th Oct. Apply here: 14.139.82.220/apps/2025/phd/ @DBTIndia @BricDbt @MAHE_Manipal @unescorcb #PhDAdmissions #phdprogramCDFD

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Reposted by Shweta Tyagi

Shweta Tyagi @shwetatyagi.bsky.social · 18/10/2025

Want to know why #microtubules should be depolymerised before #cyokinesis is completed. #mitosis #cellbiology #midbody Check out our new study in @jcellsci.bsky.social @bric-cdfd.bsky.social doi.org/10.1242/jcs....

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Shweta Tyagi @shwetatyagi.bsky.social · 18/10/2025

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Shweta Tyagi @shwetatyagi.bsky.social · 24/04/2025

Interested in centriolar satellites Read our review on why “CEP72", is the centriolar satellite 🛰️ protein to watch for doi.org/10.1002/cm.220… #centrosome, #Mitosis, #CellBiology

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Shweta Tyagi @shwetatyagi.bsky.social · 13/03/2025

Welcome sign made by the hotel staff for CDFD group! Out of the 📦 welcome !!🤗 😍

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