The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum to maintain protein homeostasis, adapt to proteotoxic stress, and regulate parasite growth and stage transitions. The prote...

Wagner et al. demonstrate that RNase H1 only removes a subset of R-loops in vivo. In yeast, overexpressed RNH1 acts more frequently at dysregulated R-loops and infrequently, if at all, at other RNA-DNA hybrids. Endogenous Rnh1 is induced in a Rad53-dependent manner at transcription-replication conflicts to promote replication completion.