iiinova — where your digital self keeps evolving

Reposted by Isabel Elaine Allen

Sarah Ackley @sfackley.bsky.social · 22/05/2026

Check out our new research letter!

Reposted by Isabel Elaine Allen

Mike Greicius @mikegreicius.bsky.social · 18/05/2026

🧪 #alzheimer #amyloid Amazing new paper from @sfackley.bsky.social that exposes the statistical alchemy Lilly applied to their donanemab data: jamanetwork.com/journals/jam... There is little to no correlation between amyoid removal and clinical outcomes with donanemab (or lecanemab).

jamanetwork.com

Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials

This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.

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Isabel Elaine Allen @datacooker.bsky.social · 28/01/2026

This is awesome - yay epidemiology!

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Stephen Senn @stephensenn.bsky.social · 14/01/2026

1) A covariate that is predictive of outcome should be in the model even if unpredictive of assignment (eg matched pairs design). 2) A covariate that is not predictive of outcome should not be in the model, even if predictive of assignment. 3) The propensity score is stupid.

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Isabel Elaine Allen @datacooker.bsky.social · 15/12/2025

Our new paper led by Yembe W. Njamnshi, MD while a GBHI Fellow @ UCSF. Using TabCAT assessment in Longitudinal Early Onset Alzheimer's Disease Study (LEADS) focusing on 3 different levels: convergent, diagnostic, & neuroanatomical validity: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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Reposted by Isabel Elaine Allen

Michael Gilman @gilman.bsky.social · 04/11/2025

Yeesh

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Reposted by Isabel Elaine Allen

Jon Keegan @jonkeegan.com · 20/10/2025

Competition is extremely intense among top AI companies to achieve computing breakthroughs that might indicate the eternally imminent arrival of AGI, so a post like this from such a high-ranking executive caught the industry’s attention.

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The Tennessee Holler @thetnholler.bsky.social · 14/10/2025

ICYMI: “And now, a response from the leader of the frog resistance...” 🐸 🎵 #Colbert

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Reposted by Isabel Elaine Allen

Patrick Cosmos @veryimportant.lawyer · 08/09/2025

working on a new unified theory of american reality i'm calling "everyone is twelve now"

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Reposted by Isabel Elaine Allen

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 12/09/2025

🔎 Meta-analysis and triangulation depend on credible science. 📈 TIME-AD’s latest paper, led by Dr. Sarah Ackley, examines 20,000+ abstracts using an LLM to determine whether P value trends reflect changes in p-hacking, publication bias, or statistical power. Read it: tinyurl.com/3f3nuxma

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Isabel Elaine Allen @datacooker.bsky.social · 22/09/2025

How left-handedness, learning differences, seizures, and autoimmune disease influence both the clinical presentation and age at onset of Alzheimer’s disease—So great to finally see this published: alz-journals.onlinelibrary.wiley.com/doi/epdf/10....

alz-journals.onlinelibrary.wiley.com

Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype

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Rudy Rucker @rudytheelder.bsky.social · 16/09/2025

9/16/25 is a Pythagorean triple day! 3 squared + 4 squared = 5 squared! A right triangle. Read my classic story "The Square Root of Pythagoras" written with Paul Difilippo. www.rudyrucker.com/completestor...

rudyrucker.com

completestories

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Isabel Elaine Allen @datacooker.bsky.social · 06/09/2025

Ugh - who taught this person statist?

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Darren Dahly @statsepi.bsky.social · 03/08/2025

haha thank you @rlgrant.bsky.social. It's ok though...memes should be free!

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Isabel Elaine Allen @datacooker.bsky.social · 08/06/2025

If you are in TimesSquare - see the billboard highlighting two of our UCSF Global Brain Health Fellows -amazing Elijah Rock sings songs you know by heart - and the artwork is by Kiggundu Rawdney. Have a listen. Funded in part by the Alzheimer’s Association.

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Maury Brown @bizballmaury.bsky.social · 30/05/2025

WHO DID THIS?!? So amazing.

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Isabel Elaine Allen @datacooker.bsky.social · 20/05/2025

Maybe ChatGPT is just prescient and is predicting books these authors will write?

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Reposted by Isabel Elaine Allen

Noah Greifer @noahgreifer.bsky.social · 18/04/2025

Resisting the urge to restart the negative binomial vs. Poisson wars...

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Isabel Elaine Allen @datacooker.bsky.social · 01/04/2025

Consider using a free textbook with your students- read the blog post:

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Mike Masnick @masnick.com · 27/02/2025

Feels like some more people around here might want to see this and share your feedback. I'm sure the folks at Heritage Foundation would appreciate your honest opinions.

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Peter Tennant @pwgtennant.bsky.social · 25/02/2025

Why else would universities be replacing all their epidemiologists with 'digital health scientists'?!

No take, only throw meme. First panel says "please analyse these data". Middle says "no thinking". Final panel "only analysing!"

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Nathan Yau @flowingdata.com · 13/02/2025

Dishonest charts are coming from all directions, and they're only going to hit harder. Unless we push back. So, an interactive guide: Defense Against Dishonest Charts flowingdata.com/projects/dis...

flowingdata.com

Defense Against Dishonest Charts

This is a guide to protect ourselves and to preserve what is good about turning data into visual things.

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Isabel Elaine Allen @datacooker.bsky.social · 15/02/2025

Is it p-hacking or sample size and power? Take a look.

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Maarten van Smeden @maartenvsmeden.bsky.social · 28/11/2024

Every time you write "there is no effect/difference (p>0.05)", when you mean "we found no evidence for an effect/difference (p>0.05)" a baby kitten dies

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