iiinova — where your digital self keeps evolving

Elias Spiliotis @septinlab.bsky.social · 23/09/2026

Tony’s Disco, Petersburg, VA This landmark opened its doors in 1970 and currently serves as a… steak house!?! Always a treat when Waze reroutes you through backroads.

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Elias Spiliotis @septinlab.bsky.social · 15/08/2026

Innovation: Investigators innovate by modifying standard techniques to fit new contexts, overcome resource limits, or address unique constraints. This adaptive approach involves customizing tools or blending distinct research traditions…

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Elias Spiliotis @septinlab.bsky.social · 10/08/2026

The Greeks are always ahead of their time…!

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Elias Spiliotis @septinlab.bsky.social · 18/07/2026

If you type "Journal of Cell Biology" in google search box and hit enter... this is the result:

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Elias Spiliotis @septinlab.bsky.social · 07/06/2026

Small club rock’n’roll (or rather post-punk) is my happy place. In DC for the last show of NYC’s Snowmen inaugural tour with Glom at DC9. #NeverTooOldForThis #MyNewestFavoriteBand

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Elias Spiliotis @septinlab.bsky.social · 10/05/2026

In primary hippocampal neurons, GSK3 inactivation promotes SEPT9-microtubule association. Phosphomimetic mutations impair asymmetric neurite growth — a key step in neuronal polarization. 🧠 Septins are downstream effectors of GSK3 in neurons. 5/7

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Elias Spiliotis @septinlab.bsky.social · 10/05/2026

This isn't just biochemistry — it works in living cells. GSK3 inhibition shifts endogenous SEPT9 toward microtubules across multiple cell types. Phosphomimetic & phosphonull mutations reproduce and reverse this effect both in cells and in vitro (images from in vitro binding below). 4/7

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Elias Spiliotis @septinlab.bsky.social · 10/05/2026

We show that GSK3 (glycogen synthase kinase 3) directly phosphorylates SEPT9 at serines 82 and 85, acting as a bidirectional switch that partitions septin between the two cytoskeletal networks. 📌 Phospho-SEPT9 → goes to actin 📌 Unphosphorylated SEPT9 → goes to microtubules 3/7

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Elias Spiliotis @septinlab.bsky.social · 10/05/2026

Septins are cytoskeletal filaments that interact with both actin and microtubules — but how cells regulate WHERE septins associate has been a long-standing mystery. We set out to find the molecular logic behind this decision. 2/7

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Elias Spiliotis @septinlab.bsky.social · 03/05/2026

44 years of receipts... finally paid. New York's next.

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Elias Spiliotis @septinlab.bsky.social · 11/04/2026

A book chapter we wrote awhile ago: Peering into the Septin Cytoskeleton – New Insights Unlocked by Microscopy Advances Andrew W. Schaefer and Elias T. Spiliotis onlinelibrary.wiley.com/doi/abs/10.1... Out now in the new Royal Microscopy Society book "Live Biological Imaging Across Scales"

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Elias Spiliotis @septinlab.bsky.social · 23/01/2026

America under the terror of… snow!

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Elias Spiliotis @septinlab.bsky.social · 17/01/2026

Comin' to ya on a dusty road... 😎😎😎

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Elias Spiliotis @septinlab.bsky.social · 26/12/2025

Tango forever! Post 2000 balls might as well be for a different sport…

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Elias Spiliotis @septinlab.bsky.social · 07/12/2025

Philly legal shark holiday spirit!

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Elias Spiliotis @septinlab.bsky.social · 30/11/2025

Blessed to see Patti Smith live in DC late night at 78 years young. The raw intensity never leaves the bodies of these old dog punks! Fury, poetry, rock’n’roll

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Elias Spiliotis @septinlab.bsky.social · 09/11/2025

Bradknam style! The new meme for all exciting neuronal cell bio results. Use in a sentence: My axon extension movies are so sick, I am hopping around the lab Bradknam style.

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Elias Spiliotis @septinlab.bsky.social · 09/11/2025

6 am ice cream breakfast in Doha, Qatar? Why not!?!

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Elias Spiliotis @septinlab.bsky.social · 08/11/2025

I didn’t expect to run into Gritty in Pune India 😳

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Elias Spiliotis @septinlab.bsky.social · 04/11/2025

In Pune, India for EMBO Cytoskeleton. Didnt have sitar performance and Filament cocktail bar in my bingo card but… hey! Come think of it every conference should feature a music performance by a local act and a bar called filament or tubule!

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Elias Spiliotis @septinlab.bsky.social · 31/10/2025

UVA Cell Biology got talent! Happy Halloween 🎃

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Elias Spiliotis @septinlab.bsky.social · 31/10/2025

Happy Halloween y’all… from the victors of the Creepiest award of the 2025 Spooktacular Carving Contest

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Elias Spiliotis @septinlab.bsky.social · 01/10/2025

Exciting news! Submissions are now open for the first @ascbiology.bsky.social #MBOC Spercial Issue on #Septins Submission deadline: April 30, 2026 RT and spread the word at #CellBio2025 www.molbiolcell.org/cell-biology...

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Elias Spiliotis @septinlab.bsky.social · 15/09/2025

SPY dyes go up by ~24% on Monday. Get them now from Cytoskeleton if your stocks getting low.

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Elias Spiliotis @septinlab.bsky.social · 25/07/2025

Must read for all music junkies… and record collectors!

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Elias Spiliotis @septinlab.bsky.social · 14/07/2025

Driving to summer conferences in the northeast means Jersey City’s legendary WFMU on the car’s terrestrial radio! Super stoked to reunite with Glen Jones radio program on my way up to FASEB cytoskeleton yesterday. Gang of Four & Frank Sinatra in the same segment is what’s all about!!!

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Elias Spiliotis @septinlab.bsky.social · 06/07/2025

Woah! Sick reconstitution work showing that MAP6d1 recruits tubulin to form B tubules on A tubule templates, and ALSO intra-luminal protofilaments, which apparently are present in neuronal microtubules. So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!

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Elias Spiliotis @septinlab.bsky.social · 03/07/2025

The (ciliary) Lords, and the (basal microtubule) Creatures @healthcare.nikon.com

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Elias Spiliotis @septinlab.bsky.social · 19/06/2025

Great talk by @mycorican.bsky.social on septin-mediated resistance of pathogenic fungi to fungicides #SeptSRC

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Elias Spiliotis @septinlab.bsky.social · 19/06/2025

Rakesh Singh @ #SeptSRC with the latest on FCF derivatives and their anti cancer properties. Septin pharmacology picking up steam! #CureCancer

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Elias Spiliotis @septinlab.bsky.social · 19/06/2025

Super exciting talk @ #SeptSRC by Friederike Arlt on septin autoantibodies linked to rare and inexplicable neurological disorder symptoms with cancer history. Possibly generated through immune response to cancer cells. So inspiring and motivating for future of septin use in medicine!

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Elias Spiliotis @septinlab.bsky.social · 19/06/2025

Last day of #SeptSRC begins with Marc Fivaz from reMYND with the most exciting septin advance of the year - a septin targeting compound that reverses Alzheimer’s symptoms in mice and patients

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Elias Spiliotis @septinlab.bsky.social · 18/06/2025

Back from coffee break with Josh Kelley and his UMaine Shmoo crew on GPCR signaling and septin roles in morphological cell response to pheremone gradients. #SeptSRac

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Elias Spiliotis @septinlab.bsky.social · 18/06/2025

Stephanie Seveau is next @ #SeptSRC on septin mediated repair of the plasma membrane damaged by the listeria toxin LLO

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Elias Spiliotis @septinlab.bsky.social · 18/06/2025

The newly minted Assistant Prof Andrew @muthrnaturzson.bsky.social Weems with compelling early data on treating melanomas by targeting septins on cancer cells that detach from the extracellular matrix in tumor borders. Super exciting! #SeptSRC

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Elias Spiliotis @septinlab.bsky.social · 18/06/2025

@maggieutgaard.bsky.social from @pwoakes.bsky.social and @myosincity.bsky.social labs with a killer talk on the coupling of the nucleus to septins in response to mechanical stress. #SeptSRC

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Elias Spiliotis @septinlab.bsky.social · 18/06/2025

Fourth day of #SeptSRC rising with Jenna Perry showing that there are septin isoforms with transmembrane proteins.

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