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Sophie Edelstein

@seedelstein.bsky.social

6 followers 9 following 6 posts

Current: Community Histories Lab 📚 & Lung Biology 🫁(Raredon Lab) at Yale Med. Formerly: Yale SPH, Yale MCDB & History

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Sophie Edelstein @seedelstein.bsky.social · 28/02/2026

Conceptually, this work suggests: Regeneration is compositionally tuned. Translational states are adaptive intermediates. Inflammation is coordinated regulation. Check out the work to learn more!

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Sophie Edelstein @seedelstein.bsky.social · 28/02/2026

Transitional epithelial states emerge across systems - hillock-like cells, Sox9+ progenitors, and secretory-alveolar intermediates. Hillock cells are notably dynamic. Their polarization and immune-regulatory signaling shift with composition. They are one node in a broader regenerative circuit.

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Sophie Edelstein @seedelstein.bsky.social · 28/02/2026

One of the most surprising findings: We can grow complex lung organoids directly from unsorted bronchoalveolar lavage (BAL) fluid - even when epithelial cells are only a small minority at seeding. From this immune-rich input, both proximal and distal epithelial lineages expand.

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Sophie Edelstein @seedelstein.bsky.social · 28/02/2026

We built a lung organoid system where the only variable we changed was the initial cellular composition. Same matrix. Same media. Same environmental conditions. Different starting communities.

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Sophie Edelstein @seedelstein.bsky.social · 28/02/2026

In chronic lung disease, repair goes awry. Epithelial cells shift identity, immune cells polarize, and tissue architecture changes. But what drives those trajectories? Signals alone or the balance of cells present at the start?

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Sophie Edelstein @seedelstein.bsky.social · 28/02/2026

As an undergrad, I started playing with what many of us call “miniature lungs in a dish.” The work evolved and is now out as a manuscript in @cp-iscience.bsky.social The question: How does starting cellular milieu shape regeneration? www.cell.com/iscience/ful...

cell.com

Pulmonary Organoid Models Demonstrate Compositionally Driven Epithelial Plasticity and Immune Polarization

Aberrant epithelial regeneration and immune remodeling are hallmarks of chronic lung diseases such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. How cellular context shap...

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