iiinova — where your digital self keeps evolving

Silvia Domcke @sdomcke.bsky.social · 25/05/2025

Expanding Perturb-seq-like screens to multicellular systems also increases the complexity of confounding effects. We encountered this when we perturbed all TFs in mosaic embryoid bodies (EBs) and develop a scalable solution by barcoding monoclonal individuals. 🧵 www.biorxiv.org/content/10.1...

biorxiv.org

Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens

Genetic screens in organoids hold tremendous promise for accelerating discoveries at the intersection of genomics and developmental biology. Embryoid bodies (EBs) are self-organizing multicellular str...

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Reposted by Silvia Domcke

Judith Kribelbauer @jk-swietek.bsky.social · 29/04/2025

How is it end of April already? Excited to share that the Kribelbauer Lab is up and running @USC/MCB. Grateful for my first two PhD students @m-finegan.bsky.social @christinagirgis.bsky.social. We are dev scalable, genome-int. tools to study TF & enhancer regulation. Website now live bit.ly/4jo8Tjg

dornsife.usc.edu

Home - Kribelbauer Lab

USC Dornsife

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Reposted by Silvia Domcke

Caleb Lareau @caleblareau.bsky.social · 14/03/2025

Trying a slightly new model (for us at least) of #openscience. With @ronanchaligne.bsky.social and @karolisk.bsky.social, we pitted 10x Genomics Chromium GEM-X against Illumina PIPseq V head-to-head to understand these two platforms for single-cell genomics. Some thoughts off the bleeding edge: /1

media.tenor.com

a baby is eating a piece of food while sitting on the ground .

ALT: a baby is eating a piece of food while sitting on the ground .

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Reposted by Silvia Domcke

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 12/02/2025

Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs… “I think they're being short-sighted, because fear does that to you.”

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Reposted by Silvia Domcke

Derek Lowe @dereklowe.bsky.social · 12/02/2025

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late. Silence gives consent. And no one should consent to this.

science.org

Stand Up And Be Counted

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Reposted by Silvia Domcke

Nagehan Ramazanoglu Bahadir @nagehanr.bsky.social · 19/11/2024

Join us for the 6th CRISPR and Beyond Conference on 2-4 April 2025!🧬 A must-attend event for researchers in high-throughput screening and #GeneEditing, exploring emerging technologies and models. #CRISPR25 👉Programme and registration: bit.ly/3Amz34N

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