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Suresh Muthukumaraswamy

@sdmuthu.bsky.social
543 followers 194 following 56 posts

Researcher at University of Auckland. Ivory tower inhabitant. Views are mine. scholar.google.co.uk/citations?user…

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Reposted by Suresh Muthukumaraswamy
Eduardo Schenberg, PhD @eeschenberg.bsky.social · 19/02/2025
Great work for psychedelic research to overcome RCT-based epistemic authoritarianism, led by @sdmuthu.bsky.social and @tehseennoorani.bsky.social 👏👏👏. Thankful for the invite to to collaborate, together with @trpwolff.bsky.social, @mattbagg.bsky.social and others. osf.io/preprints/ps... 🧪🧠💊
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 03/02/2025
Yet another pointless (scientifically speaking) study of psychedelics. With no placebo response the design is clearly a mess. I guess you can juice your stock price but you’ll never see this get published … and if you don’t publish your participant information sheets then don’t bother ….
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 16/12/2024
Please god. No more systematic reviews of psychedelics .... (at least for a while 😅)
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 12/12/2024
Full study protocol here: pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)
Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies. In light of problems with the tolerabi...
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 12/12/2024
Fair enough. You’ll note that I wrote that “as a clinical trialist” I wasn’t sorry to see it go. “As a consumer” you are right I am worse off now. We all have many hats we can don ….
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 12/12/2024
I did but nothing changed in my area so I gave up. Also I had deep concern that the loads more regulation it would have introduced is only as useful as the funding that is put into the regulatory system itself… case in point is the the current slashing of the public service.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 12/12/2024
This won’t be a popular view on the left but as a clinical trialist I am not sad to see the TPA go. The current clinical trial system works pretty well actually but the TPA had lots of uncertainty/undefined things in it - definitions that could have been really bad….
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 12/12/2024
I’m extremely curious to see more details on this one …
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 12/12/2024
Always exciting to receive the investigational product for a new clinical trial. First time I’ve had one go through a ceremonial blessing process (karakia and waiata) though … (see below for details).
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 12/12/2024
We’ve done this is humans. Paper in submission …
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 11/12/2024
Start here: pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Human Hallucinogen Research: Guidelines for Safety
There has recently been a renewal of human research with classical hallucinogens (psychedelics). This paper first briefly discusses the unique history of human hallucinogen research, and then reviews ...
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Reposted by Suresh Muthukumaraswamy
Jason Luoma, Ph.D. @jasonluoma.bsky.social · 05/12/2024
Interesting new study on "personality" change due to psilocybin administration. Lots in here, but just focusing on one element, they found that psilocybin in the lab reduced neuroticism, but not any other aspect of the Big 5. www.sciencedirect.com/science/arti... #psychedelicscience
sciencedirect.com
An investigation of acute Physiological and Psychological Moderators of Psychedelic-induced Personality Change among Healthy Volunteers
This study investigated the effects of a single high-dose of psilocybin on personality traits in psychedelic-naïve healthy volunteers. These data orig…
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 05/12/2024
There is that. The administrative overhead of doing lab /compliance paperwork across 20 sites would be a pain in the balls. I barely have the patience to do it for a single site 😂.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 05/12/2024
Yeh this struck me as weird as well and I think is intentional and perhaps reflects a negativity bias. Also hallucinogen is a bit of a weird one. More often than not they are “Pseudo-hallucinogens” as it’s much rarer for the person to actually believe the “hallucinations” are actually real …
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 05/12/2024
Difficult to believe it was costs. I know stuff is expensive in the States but a blood panel here (CNC/LFT/Renal/Thyroid) costs me less than the equivalent of $100 US pp. Scales (DEQ) etc basically free.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 04/12/2024
Following in the footsteps of lanicemine (AZD6765) and memantine (and PCN-101) as it were ….
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 04/12/2024
Can you elaborate? 🙏
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Reposted by Suresh Muthukumaraswamy
Nicola Gaston @nicgaston.bsky.social · 04/12/2024
My full comments on the cuts to the Marsden Fund of the @royalsocietynz.bsky.social are now up here:
sciencemediacentre.co.nz
Govt cuts humanities and social science funding - Expert Reaction
Humanities and social science funding has been cut from the Marsden Fund, the main fund for 'blue-skies' research in Aotearoa New Zealand. The areas that have been cut include research in subjects lik...
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 03/12/2024
Complexity in MEG/EEG. My prediction is that a good number of results are not actually showing changes in brain “complexity” but reflect spectral power changes - failing to use surrogate data properly. Some bright PhD/PostDoc should do this. Will make a great paper. I’m too time poor else I would…
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 03/12/2024
I’m not a sociologist but was introduced to this fabulous paper - Becker (1953) “Becoming a marihuana user”. Sometimes the archives of academia are amazing! www.jstor.org/stable/2771989
jstor.org
Becoming a Marihuana User on JSTOR
Howard S. Becker, Becoming a Marihuana User, American Journal of Sociology, Vol. 59, No. 3 (Nov., 1953), pp. 235-242
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Yes that is interesting. A lot to think about there.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Honestly I’m still grappling/learning about this type of research. I’m just interested to find out more and muse.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
I would be concerned that since the trials can’t be blinded that the estimands can’t uniquely identify treatment effects from placebo/expectancy effects. The same theoretical issue applies to psychopharmacology and psychotherapy trials but the latter seems to get a pass. I don’t understand why.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Awesome thanks -- will read :D
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Ok fair. I'm curious Do people ever try to do the equivalent of a dose/exposure response study as we do in pharmacology ? For example, in this case you could time limit App time in this case.....
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
💯 agree. I've read your tweets on the other place. I'll send you an email next week ... 😀
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Ok so a wait list control. Could you use a dummy app without the key therapeutic ingredients as control (dismantling). If you get a significant result how will you know it’s not all driven by expectancy effects ?
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Some kind of dismantling control condition. But really no idea without reading protocol.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Also curious why 1 is impossible ?
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Thanks. Can you send me the link to the protocol ?
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
pubmed.ncbi.nlm.nih.gov/35243919/ pubmed.ncbi.nlm.nih.gov/37947758/ @eeschenberg.bsky.social wrote a really great reply to the first of these. pubmed.ncbi.nlm.nih.gov/34227438/ Also recommend @jacobsaday.bsky.social et al's super nice expectancy paper pubmed.ncbi.nlm.nih.gov/35359159/
pubmed.ncbi.nlm.nih.gov
The challenges ahead for psychedelic 'medicine' - PubMed
With the extensive public, commercial and scientific interest from what has been widely termed the psychedelic renaissance, it is important that the scientific practices and results obtained from its ...
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
These exist 😀! Deaton and Cartwright is a classic pubmed.ncbi.nlm.nih.gov/29331519/ As is Kaputchuk (2001) pubmed.ncbi.nlm.nih.gov/11377113/ Also recommend Jeremy Howick's Philosophy of EBM book. wrt PAT I wrote a number of long/dull theoretical critiques pubmed.ncbi.nlm.nih.gov/34038314/
pubmed.ncbi.nlm.nih.gov
Understanding and misunderstanding randomized controlled trials - PubMed
Randomized Controlled Trials (RCTs) are increasingly popular in the social sciences, not only in medicine. We argue that the lay public, and sometimes researchers, put too much trust in RCTs over othe...
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 30/11/2024
Lol let's see 😀. Indeed I am trying to understand the double standards. I feel reasonably well positioned to raise the issue since modesty aside I'm pretty sure no one has written more critically about the methodological issues with PAT than I have.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
Thanks for telling me how the brain works. Appreciated.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
Psychopharmacology gets lots of criticism from psychotherapy/adjacent folks. But if someone could send me therapy trials that 1. Are double-triple blind 2. Carefully document/report AEs 3. Pre-register an SAP with ITT I would appreciate. I will wait ….
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
You are reading words/asking questions beyond what I wrote (apparent in your question). All I have said it’s not unreasonable to suppose that the brain has some mechanisms to heal itself. Call it IHI or whatever (homeostasis etc etc). That was it. I didn’t mention MDMA at all …
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
I feel my initial post on the Dodo bird may have been completely side-tracked into a debate on the MAPS model (which at the end of the day doesn’t much interest me)…. But at least some discussion because honestly blue sky has been kind of dull so far …
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
🙏 (I have skimmed Grof years ago but remember it mostly being weird unreadable claptrap 😅).
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
I don’t really understand what you’re saying to be honest. I would need examples. Plain reading of the MAPS manual doesn’t suggest this to me.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
It’s interesting generally to consider how much a theory/concept like this can actually be separated from its literature antecedents…..
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
The valid target of critique of the MAPS model then isn’t the notion of there being an IHI that might have some therapeutic usefulness. Rather it is the Grofian psychodynamic theories which are absurd. But I think it’s good to have precision in the critique.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
Which is not what I’m am saying at all. I’m simply saying that stand alone it’s not absurd to postulate that the brain has some innate ability to heal itself - and that alone seems a defensible position. The latter stuff you mention I would not attempt to defend.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
I mean frankly the finger example blows my mind as to how much inner (functional) knowledge the body is able to demonstrate it has about itself to recreate itself with so much precision.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
I’m not sure a finger repairing itself can reasonably be called regression to the mean. I’m just saying it’s not unreasonable to suppose that the brain has some capacity to heal itself (call it IHI). given the rest of the body has this ability - odd to deny the brain might have this capacity.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
In many areas of medicine doctors pretty much rely on the body knowing how to heal itself - and just provide assistance where necessary. In the case of the finger maybe some wound cleaning, antibiotics and then let the finger’s “IHI” rip …
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
I’m saying it’s not a stretch to say the finger knows how to heal itself (inner knowledge). Conceptually this is similar to concepts like autopoesis (Maturana), homeostasis or biological resilience. Pretty much all organs of the body display this characteristic so it would be weird if the 🧠 didn’t.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
I wouldn’t disagree with the premise that more research investigating different therapeutic methods in PAT is needed - not much if anything has been done yet to my knowledge.
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
Agreed - thanks (and a few more things to read😅)
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
Just for funs sake 😀. When you burn your finger and the skin heals itself … down to the immaculate detail of actually recreating your fingerprint … how would you describe that mechanistic process ? How does the finger “know” how to repair itself?
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Suresh Muthukumaraswamy @sdmuthu.bsky.social · 29/11/2024
True - perhaps (()). But important to recognise that psychotherapy research has a very poor history on reporting harms. e.g. only 21% in this meta-analysis pubmed.ncbi.nlm.nih.gov/24607768/
pubmed.ncbi.nlm.nih.gov
Reporting of harms in randomized controlled trials of psychological interventions for mental and behavioral disorders: a review of current practice - PubMed
Important information about harms is not reported systematically within this research field, suggesting that the risk of reporting bias is nontrivial in conclusions about the risk-benefit ratio of psy...
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