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Scribe Therapeutics

@scribetx.bsky.social
35 followers 1 following 196 posts
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Scribe Therapeutics @scribetx.bsky.social · 30/06/2026
Next Tuesday, we’re presenting at #GENESRC, the Genome Engineering: Research and Applications conference hosted by @faseborg.bsky.social. Details below on our session about increasing the potency of CasX-based editors to enable safer, more effective CRISPR-based therapeutics. #FASEB #CRISPR
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Scribe Therapeutics @scribetx.bsky.social · 25/06/2026
Watch the Bloomberg Originals interview to learn more about where CRISPR stands today and what comes next for genetic medicine ⬇️ www.bloomberg.com/news/videos/... Read more on @bloomberg.com ⬇️ www.bloomberg.com/news/article... #CRISPR #GeneEditing
bloomberg.com
Watch The Future of Gene Editing with Jennifer Doudna - Bloomberg
Emily Chang meets Nobel Prize-winning scientist and University of California, Berkeley, Professor Jennifer Doudna to discuss the origins of CRISPR, other breakthroughs in gene editing and what Silicon...
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Scribe Therapeutics @scribetx.bsky.social · 25/06/2026
Dr. Jennifer Doudna, Nobel laureate and Scribe co-founder, shares her vision for the future of gene editing with Bloomberg Originals host Emily Chang. Full video and article links in thread 🧵
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Scribe Therapeutics @scribetx.bsky.social · 23/06/2026
Read the @economist.com feature to learn more about our CRISPR-based epigenetic silencing technology. Scribe is now a clinical-stage company advancing STX-1150, our lead investigational therapy targeting PCSK9, in a Phase 1 study: www.economist.com/science-and-... #CRISPR #CVD #GeneticMedicine
economist.com
Genome editing can be risky. Meet the epigenome editors
The technology could tackle diseases such as atherosclerosis and hepatitis B
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Scribe Therapeutics @scribetx.bsky.social · 23/06/2026
🧬 @economist.com breaks down epigenetic medicine, the next frontier for CRISPR-based therapies: → How #EpigeneticEditing works → Potential safety advantages → How genes like PCSK9 that Scribe is focused on could be targeted to reduce LDL cholesterol and cardiovascular risk
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Scribe Therapeutics @scribetx.bsky.social · 19/06/2026
This Juneteenth, we invited our Alameda neighbor, Sips Global Tea, to share their knowledge and collection of global teas sourced from Africa, Asia, South America, and Europe with our team. Thanks for leading us through the craft and culture of tea blending for a day of learning and community 🍵
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Scribe Therapeutics @scribetx.bsky.social · 18/06/2026
Our #CRISPR-based #GeneEditing therapies STX-1200 and STX-1400 are designed for single-dose, durable lowering of key lipid drivers of ASCVD: Lp(a) and triglycerides, respectively. Read our release here: www.businesswire.com/news/home/20...
businesswire.com
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Scribe Therapeutics @scribetx.bsky.social · 18/06/2026
We’re excited to share that @cirmnews.bsky.social has awarded Scribe more than $25 million through its Preclinical Development Program to accelerate the advancement of two preclinical programs targeting cardiovascular and metabolic disease. Press release in thread 📣
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Scribe Therapeutics @scribetx.bsky.social · 17/06/2026
At #BIO2026, meet the BD team behind Scribe’s collaborations with leading pharma companies like Lilly and Sanofi. Set up a meeting using the BIO portal to learn how partnerships broaden and accelerate the impact of our engineered #CRISPR tech 👇 partner.bio.org/conference/8...
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Scribe Therapeutics @scribetx.bsky.social · 12/06/2026
Our go-to recipe for a team brunch? Good food and even better company. At Scribe, we have it down to a science. 🧑‍🍳
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Scribe Therapeutics @scribetx.bsky.social · 10/06/2026
In Precision Medicine Online, read about our first clinical trial for STX-1150, our novel, in vivo therapy designed to epigenetically silence PCSK9 and deliver sustained LDL-C reduction after a single dose – without permanently altering DNA. 📖 www.precisionmedicineonline.com/regulatory-n...
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Scribe Therapeutics @scribetx.bsky.social · 28/05/2026
Read the full report in our press release: www.businesswire.com/news/home/20... @eassociety.bsky.social #CRISPR #EpigeneticEditing #CVD
businesswire.com
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Scribe Therapeutics @scribetx.bsky.social · 28/05/2026
At #EASCongress2026, we presented late-breaking preclinical data on our lead cardiometabolic program STX-1150. These data support STX-1150 as a clinical-stage epigenetic silencing therapy designed to achieve years of LDL-C lowering after a single dose. Study highlights below ⬇️
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Scribe Therapeutics @scribetx.bsky.social · 25/05/2026
#EASCongress2026 has kicked off! A late-breaking oral presentation from our CEO @benjaminloakes.bsky.social will showcase preclinical data for STX-1150, our epigenetic silencing therapy that’s designed for durable LDL-C reduction & now in the clinic. Thanks @eassociety.bsky.social for featuring it!
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Scribe Therapeutics @scribetx.bsky.social · 22/05/2026
📰 Herald Sun article: www.heraldsun.com.au/health/unbel... 🎤 If you're at #EASCongress2026 on Monday, May 25, check out the late-breaking oral presentation by Scribe co-founder and CEO @benjaminloakes.bsky.social, highlighting our preclinical data for STX-1150: www.businesswire.com/news/home/20...
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Scribe Therapeutics @scribetx.bsky.social · 22/05/2026
In the Herald Sun, Dr. Stephen Nicholls of Victorian Heart Institute, Victorian Heart Hospital, and the PI leading Scribe's clinical trial shares his perspective on our epigenetic silencing drug STX-1150 and the need for improved therapies for cardiovascular disease. Links in thread ⬇️
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Scribe Therapeutics @scribetx.bsky.social · 21/05/2026
More details on our clinical trial and commentary from Scribe CEO @benjaminloakes.bsky.social and Principal Investigator Stephen Nicholls (Monash Health’s Victorian Heart Hospital, Victorian Heart Hospital): www.businesswire.com/news/home/20... #CVD #HeartHealth #CRISPR #EpigeneticEditing
businesswire.com
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Scribe Therapeutics @scribetx.bsky.social · 21/05/2026
STX-1150 is designed to epigenetically silence PCSK9 in the liver and deliver sustained LDL-C reduction after a single dose without permanently altering DNA, with the goal of enabling early and durable ASCVD risk reduction in patients. Link to our full announcement below ❤️‍🩹
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Scribe Therapeutics @scribetx.bsky.social · 21/05/2026
...but a novel therapy that maintains durable cholesterol lowering over decades could address these persistent gaps in cardiovascular care, while making earlier intervention and long-term prevention more practical for patients.
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Scribe Therapeutics @scribetx.bsky.social · 21/05/2026
#CVD is the leading cause of death worldwide. Many patients today still have elevated levels of LDL-C (a key lipid driver of ASCVD) due to treatment burden and adherence challenges, despite the availability of lipid-lowering therapies...
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Scribe Therapeutics @scribetx.bsky.social · 21/05/2026
This milestone marks an important step toward our goal of building genetic medicines that aim to improve outcomes and democratize access to the protective effects of beneficial human genetics. What our Phase 1 study for STX-1150 means for patients 👇
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Scribe Therapeutics @scribetx.bsky.social · 21/05/2026
Announcing our first clinical trial. Scribe has secured regulatory clearance from Australia’s Therapeutic Goods Administration to initiate a first-in-human clinical study of STX-1150 for the treatment of hypercholesterolemia, a major driver of atherosclerotic cardiovascular disease. Details🧵
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Scribe Therapeutics @scribetx.bsky.social · 18/05/2026
♥️ How our CRISPR by Design engineering approach integrates engineering of both the XE foundation to ELXR silencing machinery to enable Scribe’s lead cardiometabolic asset for LDL-C lowering @asgct.bsky.social #CRISPR #EpigeneticEditing #GeneEditing
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Scribe Therapeutics @scribetx.bsky.social · 18/05/2026
🧬 Allosteric ELXR epigenetic silencers designed to improve specificity while still achieving potent and durable target repression ⚒️ XE gene editing engineering advancements, supported by mechanistic insights into guide potency and AI-enabled predictive modeling through DeepXE
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Scribe Therapeutics @scribetx.bsky.social · 18/05/2026
At #ASGCT2026, we presented preclinical data highlighting the latest advances across our engineered #CRISPR technologies for epigenetic silencing and gene editing. Highlights of our three oral presentations below and in thread 🧵 www.businesswire.com/news/home/20...
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Scribe Therapeutics @scribetx.bsky.social · 14/05/2026
Two #ASGCT26 oral presentations tomorrow! 🔹Engineering CasX for therapeutic-grade in vivo editing with DeepXE, a predictive model for guide potency 🔹ADDing a lock to epigenome editing: DNMT3A allostery enhances specificity and potency of CRISPR-CasX-based epigenetic repressors
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Scribe Therapeutics @scribetx.bsky.social · 11/05/2026
Check out our full #ASGCT26 agenda for the week here: www.businesswire.com/news/home/20...
businesswire.com
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Scribe Therapeutics @scribetx.bsky.social · 11/05/2026
We’re kicking off #ASGCT2026 today with a workshop by co-founder & VP of External Innovation Brett Staahl. Details below & more to come at @asgct.bsky.social later this week! 🔹Engineering CasX from clay to clinic: lessons in precision, potency, and translatability 🕒 May 11 at 3:07 pm ET
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Scribe Therapeutics @scribetx.bsky.social · 30/04/2026
📊At #EASCongress2026, our late-breaker will report preclinical data for STX-1150, our PCSK9-targeting epigenetic silencing therapy for LDL-C lowering. 🔗 For more details, read our press release: www.businesswire.com/news/home/20...
businesswire.com
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Scribe Therapeutics @scribetx.bsky.social · 30/04/2026
🔬At #ASGCT2026, we'll be delivering 2 oral presentations and one workshop presentation featuring latest advances to our ELXR epigenetic silencing and X-Editor genome editing technologies, including DeepXE, our AI-enabled CRISPR design platform for predicting editing efficiency.
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Scribe Therapeutics @scribetx.bsky.social · 30/04/2026
Next month, join us at the 2026 @asgct.bsky.social Annual Meeting and @eassociety.bsky.social!
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Scribe Therapeutics @scribetx.bsky.social · 25/04/2026
Happy #DNADay26! Today, we celebrate the ongoing innovations in genetics and epigenetics that are shaping the future of human health. 🧬 At Scribe, we're committed to bringing novel #CRISPR-based genetic medicines to patients in need. Learn more at scribetx.com.
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Scribe Therapeutics @scribetx.bsky.social · 07/04/2026
This #WorldHealthDay, we’re recognizing the importance of scientific progress in improving lives. At Scribe, that mission continues to guide our work every day to advance novel #CRISPR-based genetic medicines for patients, starting with those with cardiovascular disease.
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Scribe Therapeutics @scribetx.bsky.social · 31/03/2026
What does it take to build & lead a biotech today? Some valuable insights from our CBO Svetlana Lucas at the BioPioneers #WomensHistoryMonth event: ✅ Execute with utmost focus and discipline. 📈 Get comfortable being uncomfortable. 💡 Emotional intelligence is a differentiator.
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Scribe Therapeutics @scribetx.bsky.social · 27/03/2026
To celebrate the start of spring, our team traded lab coats 🥼 for garden gloves for an afternoon of planting, propagating, and building out a community herb garden. 🌱 A fun way to welcome the season and spend time together outside the lab!
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Scribe Therapeutics @scribetx.bsky.social · 24/03/2026
Addressing Lp(a) is central to our comprehensive #CRISPR-based strategy targeting key lipid drivers of cardiovascular disease. Our STX-1200 program is designed to be a one-time therapy to durably lower Lp(a) ➡️ www.scribetx.com/news/scribe-... ACC/AHA guideline ➡️ newsroom.heart.org/news/accaha-...
scribetx.com
Scribe → Scribe Therapeutics Highlights Data Underpinning its Comprehensive Strategy Targeting Key Lipid Drivers of ASCVD at American Heart Association (AHA) Scientific Sessions 2025
Nov 17, 2025
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Scribe Therapeutics @scribetx.bsky.social · 24/03/2026
Today is #LpaAwarenessDay. Do you know your Lp(a)? Fewer than 1% of individuals with elevated levels of Lp(a) are aware of it. Now, a new @americanheart.bsky.social and @accintouch.bsky.social guideline recommends universal Lp(a) screening at least once in a lifetime. More in 🧵 #KnowLpa
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Scribe Therapeutics @scribetx.bsky.social · 20/03/2026
The @nytimes.com covers these recommendations and the importance of long-term risk reduction: www.nytimes.com/2026/03/13/h... At Scribe, we are developing STX-1150, a #CRISPR epigenetic silencing therapy designed to durably lower LDL-C by repressing PCSK9 without permanent genetic changes.
nytimes.com
Get Your Cholesterol Even Lower and Start Younger, New Guideline Says
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Scribe Therapeutics @scribetx.bsky.social · 20/03/2026
❤️‍🩹 New guideline from @accintouch.bsky.social, @americanheart.bsky.social, and other leading medical organizations reflects a key shift in cardiovascular care: → Earlier LDL-C testing → Targeting lower LDL-C levels based on risk → Greater focus on prevention over time More in our thread 👇
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Scribe Therapeutics @scribetx.bsky.social · 17/03/2026
Celebrate #WomensHistoryMonth this Thursday with a powerhouse panel of C-suite leaders, including our Chief Business Officer Svetlana Lucas. Get your ticket to the BioPioneers event for insights on the future of biotech: luma.com/583ce9z8 #WomenInSTEM #WomenInScience
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Scribe Therapeutics @scribetx.bsky.social · 13/03/2026
Scribe was created to expand #CRISPR's use beyond rare diseases, said CEO @benjaminloakes.bsky.social in an interview with @precmedonline.bsky.social. Read about our progress in bringing our lead therapy for cardiovascular disease to the clinic 👉 www.precisionmedicineonline.com/business-new...
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Scribe Therapeutics @scribetx.bsky.social · 10/03/2026
Join us at today's @keystonesymposia.bsky.social Precision Genome Engineering conference, where we're presenting our latest #EpigeneticEditing advances at 7:30pm. 📣 ADDing a Lock to Epigenome Editing: DNMT3A Allostery Enhances Specificity and Potency of #CRISPR-CasX-based Epigenetic Repressors
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Scribe Therapeutics @scribetx.bsky.social · 07/03/2026
For this International Women's Day, our Scribe team came together to assemble care packages for women and communities in need. Thank you to everyone who showed up to #GiveToGain in support of women everywhere. #InternationalWomensDay #WomenInSTEM
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Scribe Therapeutics @scribetx.bsky.social · 03/03/2026
Interested in a deeper dive into the science and engineering behind STX-1150 and our ELXR epigenetic silencing tech? Check out BioWorld’s feature on the scientific highlights for in vivo genetic medicine in 2025. www.bioworld.com/articles/727...
bioworld.com
2025 marks a breakthrough year for in vivo gene therapies
Gene editing technologies are moving forward in preclinical development with innovative strategies designed to treat diseases at their root and even reverse them. However, many approaches still strugg...
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Scribe Therapeutics @scribetx.bsky.social · 03/03/2026
Hypercholesterolemia is a major driver of cardiovascular disease. This BioWorld article covers our work to advance STX-1150 – designed to durably lower LDL-C via epigenetic silencing of PCSK9 – into the clinic and meaningfully change how #CVD is treated. www.bioworld.com/articles/728...
bioworld.com
Scribe eyes clinic with STX-1150 for hypercholesterolemia
Scribe Therapeutics Inc. is aiming to advance STX-1150, its lead product candidate for the treatment of hypercholesterolemia, into the clinic around the middle of this year. Hypercholesterolemia is a ...
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Scribe Therapeutics @scribetx.bsky.social · 27/02/2026
Read the latest in @longevitytech.bsky.social about our second success milestone with @elilillyandcompany.bsky.social and the demonstration of “steady, disciplined progress toward a future where genetic medicine plays a central role in how we manage aging and chronic disease."
longevity.technology
Gene editing partnership reaches new in vivo success
A second milestone for Scribe and Lilly highlights growing confidence in CRISPR as a tool for longer, healthier lives.
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Scribe Therapeutics @scribetx.bsky.social · 24/02/2026
In Cardiovascular Business, Dave Fornell covers: ➡️ Our lead therapy STX-1150, designed to address the gap in treatment efficacy ➡️ Preclinical NHP data showing >50% LDL-C reduction maintained for ~18 months ➡️ Phase 1 study expected in mid-2026 cardiovascularbusiness.com/topics/clini...
cardiovascularbusiness.com
Coming soon: First-in-human study of gene-modifying drug for hypercholesterolemia
Gene-editing drugs have shown potential to treat a wide variety of diseases, and this will be one of the first in cardiovascular medicine to begin human trials.
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Scribe Therapeutics @scribetx.bsky.social · 24/02/2026
At Scribe, we believe the standard of cardiovascular care today needs a paradigm shift. Cardiovascular Business spotlights our development of novel #CRISPR-based medicines that target the key lipid drivers of ASCVD – check out the article preview and link below. 👇
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Scribe Therapeutics @scribetx.bsky.social · 20/02/2026
Read the @forbes.com daily cover story on Dr. Doudna: www.forbes.com/sites/amyfel... And a 2023 feature on Scribe: www.forbes.com/sites/alexkn... #CRISPR #GeneEditing #GeneticMedicine
forbes.com
Jennifer Doudna’s $1 Billion Plan To Bring Gene Editing To The Masses
Crispr’s ability to cut genetic code like scissors has just started to turn into medicines. Now, gene editing pioneer Jennifer Doudna wants to build an entire ecosystem to bring these treatments mains...
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Scribe Therapeutics @scribetx.bsky.social · 20/02/2026
Dr. Jennifer Doudna, Nobel laureate & Scribe co-founder, is one of America’s greatest innovators. Our CEO and co-founder @benjaminloakes.bsky.social spoke with @forbes.com about her unmatched impact on science and medicine. Check out Dr. Doudna’s Forbes 250 profile in the links below 👇
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