iiinova — where your digital self keeps evolving

Reposted by Precision Medicine Online

My Gene Counsel @mygenecounsel.bsky.social · 03/12/2024

"This case is concerning because the neurologist not only ordered the wrong test but didn't recognize the error even after seeing a report...entirely unrelated to ataxia." The latest in GenomeWeb's Genetic Testing Challenges series with @ellenmatloff.bsky.social @turnaray.bsky.social: bit.ly/3OzvtIf

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turnaray.bsky.social @turnaray.bsky.social · 12/12/2024

A case is making its way through the Colorado courts, in which the parents of twins -- a boy with Duchenne and a girl who is a DMD mutation carrier -- are suing Children's Hospital Colorado and GeneDx for alleged negligent genetic counseling and testing. My article: www.genomeweb.com/molecular-di...

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Appeals Court Finds Negligence Claims Against Hospital, GeneDx Valid Under Colorado Statute

Parents are suing the defendants for negligent genetic counseling and testing that they allege precluded their ability to avoid having children with Duchenne.

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Catherine Shaffer @cathshaffer.bsky.social · 11/12/2024

First-in-human results are out for three next-gen mutant PI3ka inhibitors for ER+ BC. The Scorpion and Relay compounds are headed to new trials while Loxo@Lilly is pivoting to a preclinical program due to diarrhea w/LOXO-783. #SABCS

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Catherine Shaffer @cathshaffer.bsky.social · 11/12/2024

A stem cell transplant added did not improve survival for mantle cell lymphoma patients in their first remission who had undetectable residual cells in their blood samples by a very sensitive test, a study showed. This means most patients can likely skip having a risky stem cell transplant.

precisionmedicineonline.com

Adaptive Biotechnologies' MRD Test May Allow Some Mantle Cell Lymphoma Patients to Skip Transplant

A stem cell transplant added to Rituxan did not improve survival for MRD-negative MCL patients in their first remission compared to Rituxan alone, a study showed.

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Catherine Shaffer @cathshaffer.bsky.social · 06/12/2024

I recently covered two new digital pathology tools-GigaPath and Ataraxis Breast-that incorporate transformer algorithms, the same type that underly GPTs. In this case a self-supervised vision transformer called DINOV2 developed at Meta. #medsky #oncsky #oncology #scicomm 🧵

precisionmedicineonline.com

GigaPath Developers Aim to Accelerate Digital Pathology for Cancer Outcomes Predictions

A foundation model built with the GigaPath algorithm outperformed other such pathology models in cancer subtyping and other prediction tasks.

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