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Saloni

@scientificdiscovery.dev
47K followers 1.2K following 5.4K posts

Co-founder & editor, Works in Progress. Writer, Scientific Discovery. Podcaster, Hard Drugs. Advisor, Coefficient Giving. Newsletter: scientificdiscovery.dev Podcast: harddrugs.worksinprogress.co 🏳️‍🌈

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Saloni @scientificdiscovery.dev · 17h
London City Airport is my favourite one in London in part because the descent has views like this
Cityscape from the plane window
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Saloni @scientificdiscovery.dev · 28/09/2026
I don't mean to brag, but this is one of the best videos I have ever taken, feat. @dingdingpeng.the100.ci
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Saloni @scientificdiscovery.dev · 27/09/2026
Omg thanks to @dingdingpeng.the100.ci I'm now the proud sponsor of a Gila monster at the zoo 🦎 One of the most important lizards in medical history! There it is, sleeping on the right.
Me holding a Gila monster plushie in front of a Gila monster exhibitGila monster sleeping
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Saloni @scientificdiscovery.dev · 25/09/2026
Here's a link to the game: game.clinicaltrialsabundance.blog I promise it's fun, and some of my friends have gotten really competitive about it! There are leaderboards, and there's a bonus game you can unlock if you solve the challenge.
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Saloni @scientificdiscovery.dev · 25/09/2026
Very fun to see how many people have played already. Each line here represents a successful completion, and there were many different ways to solve the game!
A mysterious unlabelled chart of solutions to the game.
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Saloni @scientificdiscovery.dev · 25/09/2026
If you complete the challenge, you'll unlock a bonus game where you can steer a raft down bottleneck river ⛵️
Take a ride along bottleneck riverA little boat floating inside a champagne bottle
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Saloni @scientificdiscovery.dev · 25/09/2026
Happy Friday! Iʼve created a game for you to play! Will AI cure all diseases in 10 years? Inspired by bottlenecks discourse, I created a game to help build your intuitions. Play it here: game.clinicaltrialsabundance.blog Naturally, it’s bottle-themed with bubbles and there are leaderboards too.
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Saloni @scientificdiscovery.dev · 25/09/2026
Her cheeks are comically chubby
The chonkiest of cheeks
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Saloni @scientificdiscovery.dev · 25/09/2026
. @dingdingpeng.the100.ci's baby is so chubby, I had to find out how our face sizes compared, side by side. Unfortunately I still can't tell. It's debatable
Saloni vs Emmy head size comparison
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Saloni @scientificdiscovery.dev · 24/09/2026
I have just eaten a mango-shaped mango ice cream. It was mangonificent
Me eating mango ice cream
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Saloni @scientificdiscovery.dev · 24/09/2026
I have just eaten my first Spaghettieis. It felt very unnatural to eat it with a spoon.
Spaghetti shaped ice cream
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Saloni @scientificdiscovery.dev · 17/09/2026
And I didn't want to be any of these, so I clicked I Don't Care.
What do you want to be when you grow up?
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Saloni @scientificdiscovery.dev · 17/09/2026
This question was hard by the way. My favourite subject at school was English, which wasn't an option here, but break time ranked higher than the others.
What's your favourite subject at school? Drama, I don't mind, PE, Science, Break time, Art and design, Maths
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Saloni @scientificdiscovery.dev · 17/09/2026
OMG I am my favourite type of potato
"You are a roast potato"
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Saloni @scientificdiscovery.dev · 13/09/2026
I'm very happy to learn that "kettlebaby" is a real thing. You can simply lift them by the handles.
Stop the tradeoff between spending time with your kids and exercisingKettlebaby
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Saloni @scientificdiscovery.dev · 12/09/2026
A fox sneakily typing on the computer
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Saloni @scientificdiscovery.dev · 12/09/2026
Ordered a "baklava sandwich" yesterday, not knowing what that meant. It turned out to be layers of baklava with cream on top and pistachio ice cream inside. Probably in the top 3 desserts in my life tbh.
Pic of the baklava cake
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Saloni @scientificdiscovery.dev · 08/09/2026
Not sure about these AI-suggested replies though.
Yuck!

(sad face)

AI suggested replies: Thanks, Yay, I know
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Saloni @scientificdiscovery.dev · 08/09/2026
Wow! Wait but I don't understand - does it use the same glass container to mix and collect dust? Hopefully people cleaned it well between uses
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Saloni @scientificdiscovery.dev · 07/09/2026
A lot of people made fun of this at the time, but I actually don't think it's that bad. Mostly it amuses me to imagine feeding two birds one scone.
Peta's stop using anti animal language campaign
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Saloni @scientificdiscovery.dev · 05/09/2026
God it looks delicious
Zoomed in map
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Saloni @scientificdiscovery.dev · 05/09/2026
I like the new map projection, but India looks more like a pizza slice than I'm used to
New UN map
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Saloni @scientificdiscovery.dev · 05/09/2026
Or perhaps I'm wrong and it is actually population-weighted? From Population Reference Bureau: Roughly 15% of people were born in the last 2 centuries, vs 85% were born in all previous years combined. www.prb.org/news/how-man...
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Saloni @scientificdiscovery.dev · 05/09/2026
Skinner meme
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Saloni @scientificdiscovery.dev · 03/09/2026
That's crazy. ... Must be because of the -loni in her name. I have no conflicts of interest to report.
Meloni's government becomes the longest serving in Italy since 1943
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Saloni @scientificdiscovery.dev · 02/09/2026
I wrote briefly on the recent antibody image scandal for our weekly round up www.abundanceandgrowth.org/p/california...
Can antibody explain these images? — Saloni Dattani
Back in May, science sleuth Sholto David came across a suspicious image from the major life-sciences supplier Thermo Fisher. It was a Western blot showing the performance of one of their antibodies that is commonly used in cancer research. On the blot, four apparently separate protein bands were copies of the same shape, duplicated and flipped or rotated to produce the others.

Since then, Reese Richardson, a metascience and computational biology researcher and other sleuths uncovered many more by increasing image contrast and searching suppliers’ catalogues for repeated visual fingerprints, partly using image-search tools. According to Nature, they have now found over 18,000 questionable images across 15 commercial suppliers, with digital alterations such as repositioned bands, painted-over regions, and reused background noise. For the last category, Elisabeth Bik (who some say has forensic laser eyes) told Nature, “That particular type of image alteration or manipulation suggests that these antibodies were never tested at all in the lab.” Weirdly, identical images were sometimes used by multiple suppliers, which suggests that they came from the same third-party manufacturers.

The images don’t necessarily mean the antibodies themselves are flawed, but since other research has found that commercial antibodies are commonly unreliable, I wonder whether this is just the tip of the iceberg, and how much of scientists’ time has been wasted chasing false leads. One takeaway is that researchers should avoid relying on suppliers’ images and independently validate their antibodies. But given how time consuming and repetitive it would be for individual scientists to validate them, a wider effort seems worthwhile. For example, the Canadian open-science company YCharOS tests some commercial antibodies head-to-head and publishes their results openly, and the University of Leicester’s ‘Only Good Antibodies’ hosts this data on a searchable database, though neither are comprehensive. The sleuths themselves also host a Zenodo repository with their findings.
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Saloni @scientificdiscovery.dev · 01/09/2026
*day 680 of learning German* I just understood a joke without pressing the translate button 🥳
Woher kommt sie eig? 
*Pakistani flag*
Was das
Vegane Turkey oder was
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Saloni @scientificdiscovery.dev · 26/08/2026
I wrote about the Moderna cancer vaccine news briefly for our weekly round up www.abundanceandgrowth.org/p/cancer-vac...
Personalized cancer vaccines are now real — Saloni Dattani
Researchers have spent decades trying to develop personalized cancer vaccines, and last week, the first one succeeded. It’s called intismeran autogene (mouthful), was developed by Moderna and Merck, and involves sequencing melanoma patients’ cancer mutations, creating a custom mRNA to target them, and delivering the vaccine to stop the cancer recurring. The news came as the drug passed its interim goal in a phase three trial, where it was given to people with high-risk resected melanoma.

It led to Moderna’s stock jumping 177%, which was apparently the largest one-day gain by any S&P 500 stock this century. I found the size of the surge surprising because you could have already been fairly confident that the drug would succeed since at least June: as I wrote in an earlier post, the company presented data from their phase 2b trial at an oncology conference almost three months ago, which showed a 49% reduction in the risk of recurrence or death (p = 0.0075). But, according to financial analysts, the huge market reaction was probably down to a short squeeze and the belief that mRNA could be a more widely useful platform to develop other cancer vaccines too.

That makes sense, but it’s worth knowing that melanoma is a much easier disease to develop cancer vaccines for than others. It carries a very high number of mutations, so you have thousands of possible ‘neoantigens’ to select from and can choose those that look strong on many measures, but this isn’t the case for many cancers. Many cancers have far fewer mutations to select from, and it’s currently hard to predict whether their mutations will be displayed or measure which ones actually are displayed.But very few people thought this attempt would work either, until recently. According to a very interesting new STAT article detailing how this cancer vaccine came about, Moderna’s own executives didn’t expect it would work until 2023; it first entered clinical trials in 2017. In case you’re interested in more about personalized cancer vaccines, I’ll once again recommend this great podcast episode, How to design a cancer vaccine, hosted by Owl Posting and featuring Alex Rubinsteyn and Benjamin Vincent, two scientists whose work focuses on cancer immunology and vaccines.

Chart of Moderna share price
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Saloni @scientificdiscovery.dev · 24/08/2026
Amusing to learn that a goddess became largely redundant as a result of the smallpox eradication campaign en.wikipedia.org/wiki/Shitala
Shitala (Sanskrit: शीतला, IAST: śītalā, lit. 'coolness'; also spelled as Sheetala, Śītalā and Seetla) is a Hindu goddess venerated primarily in North India.[2] She is regarded as an incarnation of the goddess Parvati and is believed to cure poxes, sores, ghouls, pustules, and diseases, and most directly linked with the disease smallpox. Shitala is worshipped on Tuesday,[3] Saptami and Ashtami (the seventh and eighth day of a Hindu month), especially after Holi during the month of Chaitra. The celebration of the goddess Shitala on the seventh and eighth day of the Hindu month is referred to as the Shitala Saptami and Shitala Ashtami, respectively.[4]
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Saloni @scientificdiscovery.dev · 19/08/2026
Is it normal to get >111,000 views in 2 days? That seems like… a lot.
Thumbnail of my TED talk: We've solved many medical mysteries. Where are the cures? 111k plays - published 2 days ago.
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Saloni @scientificdiscovery.dev · 18/08/2026
The tools to develop new drugs and vaccines have improved enormously, so why haven't we cured all diseases yet? Medical innovation isn't just about the science - it's about the funding, incentives and institutions, and most importantly, on people who choose to solve problems.
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Saloni @scientificdiscovery.dev · 17/08/2026
It's finally here! I gave a TED talk in April in Vancouver, and it was released online today. You can watch it here: ted.com/talks/saloni... I've also adapted it into an article, which was published last week: worksinprogress.co/issue/future...
Me on the TED stage
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Saloni @scientificdiscovery.dev · 12/08/2026
I wrote briefly on the Ebola situation. Things could be going a lot better than they are. www.abundanceandgrowth.org/i/210835777/...
A keyhole view of the next pandemic — Saloni Dattani
I’ve been following the Ebola outbreak in central Africa, which has just surpassed 2,000 reported deaths and 4,381 confirmed cases. (The real numbers are likely higher due to underdetection.) What’s surprising about the Ebola outbreak is that we actually have an Ebola vaccine, but it was developed and tested against the Ebola Zaire virus during the 2014–2016 outbreak, while this outbreak is caused by Ebola Bundibugyo virus. The two viruses have similarities and some laboratory and animal data suggested there may be cross-protection, although the evidence is still unclear.1 But until last week, the WHO hadn’t decided to test that vaccine in this outbreak; the focus was on developing and testing new Bundibugyo-specific vaccines and antivirals instead.

In a recent STAT opinion piece, Krutika Kuppalli and Placide Mbala argue that pandemic preparedness shouldn’t be so narrow. Rather than focusing so narrowly on each virus, we should invest in broad-spectrum diagnostics, vaccines, and treatments, and should have tested the effects of the Zaire vaccine on Bundibugyo earlier; I agree.

Interestingly, the Ebola Zaire vaccine came about through innovative trials and coordination. It was developed through funding by BARDA and the DoD, tested using ring vaccination trials led by the WHO, incentivized through an advance market commitment, and stockpiled by Gavi, WHO, UNICEF and the Red Cross for future outbreaks. That stockpile has been useful in the years since then to contain outbreaks of Ebola Zaire quickly. But now that a larger, harder to contain outbreak has arrived, we’ve lost expertise and funding to tackle it, and we don’t know if the existing Ebola vaccine protects against this virus too. We could be doing a lot better.
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Saloni @scientificdiscovery.dev · 10/08/2026
I'm George Bush and I see a shoe being hurled at me what do I do
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Saloni @scientificdiscovery.dev · 09/08/2026
Q: I'm an egg on a counter and I see a cat coming towards me what do I do

A: Brace for impact... I can calculate your terminal velocity and the exact probability of an omelet outcome.
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Saloni @scientificdiscovery.dev · 09/08/2026
I have found the one and only good use of Gemini and I need to stop
Search history: I'm a broccoli pretending to be a plane and I see a baby's mouth in front of me what do I do

And other searches
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Saloni @scientificdiscovery.dev · 09/08/2026
From the CDC's smallpox eradication manual. I can't—
Drawings of two squarish looking people without hands or shoes and barely a neck
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Saloni @scientificdiscovery.dev · 07/08/2026
I find this, 1806 letter from Thomas Jefferson to Edward Jenner, so moving 🥺
To Dr. Edward Jenner Monticello, May 14, 1806
The Letters of Thomas Jefferson

SIR,
-- I have received a copy of the evidence at large respecting the discovery of the vaccine inoculation which you have been pleased to send me, and for which I return you my thanks. Having been among the early converts, in this part of the globe, to its efficiency, I took an early part in recommending it to my countrymen. I avail myself of this occasion of rendering you a portion of the tribute of gratitude due to you from the whole human family. Medicine has never before produced any single improvement of such utility. Harvey's discovery of the circulation of the blood was a beautiful addition to our knowledge of the animal economy, but on a review of the practice of medicine before and since that epoch, I do not see any great amelioration which has been derived from that discovery. You have erased from the calendar of human afflictions one of its greatest. Yours is the comfortable reflection that mankind can never forget that you have lived. Future nations will know by history only that the loathsome small-pox has existed and by you has been extirpated.

Accept my fervent wishes for your health and happiness and assurances of the greatest respect and consideration.
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Saloni @scientificdiscovery.dev · 04/08/2026
me right now
galaxy brain meme - lvl 1: smallpox was eradicated because it was an easy disease to eradicate.
lvl 2: smallpox was eradicated because of technology
lvl 3: smallpox was eradicated because of funding
lvl 3: smallpox was eradicated because of statisticians
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Saloni @scientificdiscovery.dev · 02/08/2026
Whooops. I made a mistake while describing the mechanism of immortal time bias in our last episode. Ironically, it was just after I explained how confusing I found many explanations of it, but my own explanation was also confused! 😂🫠
But one of the interesting things about that was that the evidence for this before the trials were done were observational studies. Some of these observational studies were affected by various biases. One of these biases is called immortal time bias. Have you heard of that?

Jacob Trefethen: I'm pretty biased myself as a immortal demigod. Yes. But what about you?

Saloni Dattani: I had, well, I had heard about this for a long time and I was like, what does that, why is it called that? I feel like hardly anyone had given me an explanation of this that made sense. It was like really complicated and people would explain it with these diagrams that were very difficult to read.

But the basic idea is that you have, you're looking at like, let's say hospital data or something, and you're comparing people who have taken a drug to people who haven't. You look at, while they're on the drug, what are their chances of developing the disease versus people who are not on the drug?

What a lot of these studies would often do is that they count the time that people are not on the drug, or before they start the drug, in the control group [Correction: in the treated group], and they take the time that they spend on the drug in the treated group [as well]. But that creates a problem.
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Saloni @scientificdiscovery.dev · 02/08/2026
Omg why is Bluesky's translation service so bad
Life at the limit (short with the baby turn a round without taking a spooky)
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Saloni @scientificdiscovery.dev · 31/07/2026
It's part of Duolingo's attempts at humour 🤦‍♀️
Tell me, Grandma. Why do you take all your money from the bank?'

I trust my sofa more than that bank.

Cool. Me too
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Saloni @scientificdiscovery.dev · 30/07/2026
pic unrelated, that's me on the right
An absurd pictogram of average female height per country, with the icons not scaled properly
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Saloni @scientificdiscovery.dev · 28/07/2026
Look who's in the show notes as well 🤩
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Saloni @scientificdiscovery.dev · 25/07/2026
I love this clip of @jacobtref.bsky.social on the wonder of drug repurposing in the RECOVERY trial:
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Saloni @scientificdiscovery.dev · 24/07/2026
Saloni Dattani: Yep. Then there's omalizumab that I mentioned at the start. That was originally developed as an asthma drug. But more recently, it's shown to be effective for various food allergies. Peanut, milk, yeah, various food allergies. Then you brought up Viagra, Sildenafil.

Jacob Trefethen: I didn't bring that up! You brought that up!
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Saloni @scientificdiscovery.dev · 23/07/2026
These backronyms need to STOP (Seriously this isn'T funny Or apPropriate)
Our PETRUSHKA (Personalise antidEpressant TReatment for Unipolar depreSsion combining individual cHoices, risKs and big datA)
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Saloni @scientificdiscovery.dev · 22/07/2026
Amazed this is real
Google search: How many days of the week have poop in it

Google: Technically exactly one day of the week contains the word poop-- Wednesday (Wednes-poop)
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Saloni @scientificdiscovery.dev · 22/07/2026
I just noticed that Naomi Wolf, of all people, follows me on Substack 😂 I wonder what she gets out of it. Maybe she's interested in the latest developments in time travel technology.
Naomi Wolf tweet: Terrifying. Also confirms/explains the conversation I overheard in a restaurant in Manhattan 2 yes ago in which an Apple employee was boasting about attending a top secret demo: they had a new tech to develop vaccines w nanopatticles (sic) that let you travel back in time. Not kidding
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Saloni @scientificdiscovery.dev · 21/07/2026
I made something similar for this www.clinicaltrialsabundance.blog/p/why-were-c...
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