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Oleksandra Sasha Fanari

@sashafanari.bsky.social
11 followers 32 following 0 posts

PhD Candidate in BIOE at Northeastern University RNA ~ RNA mods ~ pseudouridine

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Reposted by Oleksandra Sasha Fanari
Sara Rouhanifard @srouhanifard.bsky.social · 21/03/2025
1/6 🧬New paper at @cp-cellsystems.bsky.social led by @sashafanari.bsky.social! Does pseudouridine (Ψ) dynamically respond to cell state? We used nanopore DRS + Mod-p ID to map Ψ in neuron-like cells under “normal” and “perturbed” conditions (healthy differentiation and unhealthy Pb2+ poisoning).
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Reposted by Oleksandra Sasha Fanari
GenomeTDCC @genometdcc.org · 10/03/2025
🧪🧬👩‍🔬🖥️ Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔 @sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells 👇 doi.org/10.1101/2025...
doi.org
Direct RNA sequencing of primary human T cells reveals the impact of immortalization on mRNA pseudouridine modifications.
Immortalized cell lines are commonly used as proxies for primary cells in human biology research. For example, Jurkat leukemic T cells fundamentally contributed to uncovering T cell signaling, activat...
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Reposted by Oleksandra Sasha Fanari
bioRxiv Genomics @biorxiv-genomic.bsky.social · 10/03/2025
Direct RNA sequencing of primary human T cells reveals the impact of immortalization on mRNA pseudouridine modifications. www.biorxiv.org/content/10.1101/202…
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Reposted by Oleksandra Sasha Fanari
Randall Munroe @xkcd.com · 26/02/2025
RNA xkcd.com/3056
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