A naturally occurring bacterium from amphibian intestines completely eliminated colorectal tumors in mice with a single treatment by both attacking cancer cells and activating the immune system. The f...

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, hig...

Renal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-like progenitor features and reduced...

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

Dr Robert Sorrell sets out his tests for difficult R&D choices – and why we must protect curiosity-driven science and core skills at the same time

YouTube video by UK Research and Innovation

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Abstract. Ewing sarcoma is characterized by a chromosomal translocation resulting in the fusion protein EWSR1::FLI1. We utilize endogenous EWSR1::FLI1 target gene reporters in patient-derived cell lin...

Abstract. Alveolar rhabdomyosarcoma (aRMS) is a fusion-driven pediatric cancer with poor survival and limited therapeutic options. To uncover novel vulnerabilities, we employed complex-based analysis ...