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Sandra Ledesma-Corvi

@sandracorvi.bsky.social
83 followers 57 following 0 posts

PhD, neuropharmacology, age and sex differences, depression 🧠

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Reposted by Sandra Ledesma-Corvi
Liisa Galea @liisagalea.bsky.social · 09/09/2026
Our new preprint with @ciernialab.bsky.social we investigated transcriptional profiles of microglia (❤️the name) from hAPOEe4/3 female/male mice in HPC &CTX. We saw loads of sex x genotype interactions in both regions Cell cycling, ER stress, lipid metabolism ++ www.biorxiv.org/content/10.6...
biorxiv.org
Sex and APOE Genotype Differentially Shape Microglial Transcriptomic Profiles Across the Hippocampus and Cortex
Female sex and the APOEε4 allele are top risk factors for Alzheimer’s disease (AD). Microglia play a role in the pathogenesis of AD, yet how sex and APOE genotype affect microglia remain poorly unders...
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Reposted by Sandra Ledesma-Corvi
Liisa Galea @liisagalea.bsky.social · 11/07/2026
Up next for the Galea lab at #AAIC26 are 4 posters and 1 talk. Please join us to talk about sex, menopause and APOE4 in mouse models and women! @matejaperovic.bsky.social @sandracorvi.bsky.social
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Reposted by Sandra Ledesma-Corvi
Liisa Galea @liisagalea.bsky.social · 07/04/2026
Last week was a good week for the microgaleas… 2 successful CIHR CPRA and 1 CGSM! Congrats to Dr @sandracorvi.bsky.social Erika Teeter Dr Jesse Lacasse!!
media.tenor.com
a man applauds with the words way to go super proud of you behind him
ALT: a man applauds with the words way to go super proud of you behind him
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Reposted by Sandra Ledesma-Corvi
Alaina Jaster, PhD @jasteralaina.bsky.social · 20/11/2025
My dissertation paper finally dropped in Nature Communications! Overall, the conclusion is that psilocybin may be useful in reducing drug craving that often precipitates relapse through mechanisms related to 5-HT2A activation. www.nature.com/articles/s41...
nature.com
Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward - Nature Communications
Here Jaster et al., show a single psilocybin dose produce sex-specific post-acute changes in opioid reward and withdrawal via 5-HT2A receptors in frontal cortex-to–nucleus accumbens circuits, with epi...
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Reposted by Sandra Ledesma-Corvi
Women's Health Research Cluster @whrcluster.bsky.social · 03/09/2025
📢 Call for Abstracts! Submit by Oct 1 to present in our Trainee Research Presentation Series: 💡 Hormonal Contraceptives: Insights from Across the Field 📅 Nov 14, 2025 | Hybrid (Toronto + online) 🔗 Details: ow.ly/KTq750WIenV #WomensHealth #ResearchOpportunity
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Reposted by Sandra Ledesma-Corvi
Women's Health Research Cluster @whrcluster.bsky.social · 28/08/2025
✨ New Publication Feature ✨ How you take #menopausal #hormonetherapy may shape its impact on #cognition. A new study by Puri et al. from @liisagalea.bsky.social's group shows route of estradiol administration and cognitive domain matter. Learn more from the full paper here: 📖 ow.ly/ohlF50WNJiU
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Tracy Bale @thebalelab.bsky.social · 26/08/2025
Community engagement event for #BrainFest in Denver #Headstrong is a twist on #WomensBrainHealth across the lifespan using comedy! Denver's top women comedians paired with @cuanschutz.bsky.social top women scientists for an incredible show. If you're in the area Sept 5, come laugh your stress off!
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Reposted by Sandra Ledesma-Corvi
mark cembrowski @markcembrowski.bsky.social · 22/05/2025
fantastic day at the 2025 Neural Circuits and Behaviour Satellite meeting! great talks by trainees Xin Zhao, Govind Peringod, Luca Pancotti, and Peiying Wen, and congrats to Govind for his top trainee talk award! so cool to see all the great circuits and behaviour work across the country
The room of attendees at the 2025 CAN Neural Circuits and Behaviour Satellite Meeting.
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Science News @scinews.bsky.social · 25/04/2025
Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors "The identification of this prominent neuron-glia interaction may shed light on stress management and depression prevention." www.cell.com/cell/abstrac...
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Reposted by Sandra Ledesma-Corvi
Miguel Branco @brancolab.bsky.social · 23/04/2025
So depressing...
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Reposted by Sandra Ledesma-Corvi
Mathias V. Schmidt @mathiasvschmidt.bsky.social · 23/04/2025
Read about our recent discoveries on mechanisms that can drive resilience in females. www.psych.mpg.de/2949097/news...
psych.mpg.de
Early Life Stress Can Build Resilience in Females
Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...
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Reposted by Sandra Ledesma-Corvi
Women's Health Research Cluster @whrcluster.bsky.social · 01/04/2025
Join us for a Multidisciplinary Look at Menopause! 🗓️ April 28 – 1:00 PM EST Hear insights from the next generation of menopause researchers! 🔗 Reserve your spot today for this hybrid event: ow.ly/T8g350VpOap #MenopauseResearch
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Reposted by Sandra Ledesma-Corvi
Women's Health Research Cluster @whrcluster.bsky.social · 28/03/2025
Did you know that APOEe4, a genetic risk factor late-onset sporadic #AlzheimersDisease (AD) affects brain aging differently in males and females? 🧠 👀 📲 Swipe to learn more about this new study led by @bonniee_leee and click here to read the full paper: bsd.biomedcentral.com/articles/10....
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Healthy Brains, Healthy Lives @hbhlmcgill.bsky.social · 20/03/2025
Join us on April 9 at @theneuro.bsky.social for a must-attend event on sex- and gender-based analysis plus (SGBA+) in neuroscience research! Hear from experts @liisagalea.bsky.social & @rpjuster.bsky.social, join the discussion on #SGBA+ and network with colleagues. 👐 Register now: mcgill.ca/x/i3G
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Reposted by Sandra Ledesma-Corvi
Infosalut @infosalut.bsky.social · 20/03/2025
#PublicaSalutIB 🐀💊 @jordijornet.bsky.social  , @sandracorvi.bsky.social i @garciafusterlab.bsky.social de @idisba.bsky.social han publicat la caracterització de l'ús terapèutic de la ketamina en rates adolescents  www.infosalut.com/17236 doi.org/10.1016/j.biopha.2024.117781
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Reposted by Sandra Ledesma-Corvi
Liisa Galea @liisagalea.bsky.social · 05/02/2025
Here’s my statement as Lead for @whrcluster.bsky.social on the importance of studying women’s health- (& the importance of within & across sex & gender investigations) for our best chance at precision medicine womenshealthresearchcluster.com/learn/womens...
womenshealthresearchcluster.com
Statement from Liisa Galea, Scientific Lead of the Women's Health Research Cluster - Women's Health Research Cluster
We are so proud to have over 800 members across 32 countries in the Women’s Health Research Cluster. Our Vision is to achieve sex and gender health equity, and we strive for a future where women...
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The Transmitter @thetransmitter.bsky.social · 28/01/2025
Sex-related factors are important in two ways; they are more precise variables than sex, and they are gender-independent, writes @kundakoviclab.bsky.social in the latest essay in our “Sex differences in the brain” series. www.thetransmitter.org/sex-differen... #neuroskyence
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Julia Garcia-Fuster @garciafusterlab.bsky.social · 22/12/2024
Celebrating a year full of accomplishments with these great bunch of people. Happy holidays 🙂
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