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Sam Foley

@samuelfoley.com
1K followers 684 following 880 posts

Physics of membranes and self-assembly || Biophysics postdoc at Johns Hopkins || Previously Penn State -> Carnegie Mellon || for I perplex others not because I am clear, but because I am utterly perplexed myself || www.samuelfoley.com

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Sam Foley @samuelfoley.com · 5h
BPS abstract day tradition
Cloudflare error when trying to access www.biophysics.org
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Sam Foley @samuelfoley.com · 22h
I had a Bitcoin wallet when they were worth ~1 cent each. I have many regrets.
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Sam Foley @samuelfoley.com · 29/09/2026
Intruders under the blanket!
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Sam Foley @samuelfoley.com · 29/09/2026
Intruders under the blanket!
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noam @noamchompers.bsky.social · 27/09/2026
Postdoc appreciation week is over, so please, STOP appreciating postdocs. They will get some more appreciation next year
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Sam Foley @samuelfoley.com · 27/09/2026
This guy Vongs
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Sam Foley @samuelfoley.com · 27/09/2026
The secret is that Bob Iger is the one who actually ruined Star Wars by rushing every part of the process.
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Sam Foley @samuelfoley.com · 26/09/2026
Extra funny here is the fact that these movies are so divisive that I don't even know which two you mean. I've encountered people who would say 7&9, 7&8, or 8&9.
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Sam Foley @samuelfoley.com · 25/09/2026
I know there's a lot of recency bias involved, but I would honestly put Succession at #1. I don't think I've ever been that hooked on a show before or since. Parks and Rec, Peep Show, and IASIP should all be higher.
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Sam Foley @samuelfoley.com · 25/09/2026
Nicolaas van Kampen's essay on the Gibbs Paradox, in addition to being an insightful, no-nonsense explanation gas entropy and indistinguishability ("Quantum mechanics has no bearing on the question"), opens with some comments on physics education that were ahead of the times for 1984!
Beste Dik,
It is a long time since we both attended the lectures by Mrs de Haas-Lorentz on thermodynamics. They were excellent from a pedagogical point of view since they forced you to figure out almost everything yourself. That is a much better way of learning physics than the spoonfeeding of predigested formalisms which is nowadays regarded as the highest wisdom in education. I remember how puzzled I was by the sudden appearance of the term —kN log N in the entropy. After I figured it out I found that there is still much confusion about it in the literature. That is my excuse for bothering you with such a time-worn subject.
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Rob Beschizza @beschizza.com · 23/09/2026
The time is nearly perfect for a movie about the famously chaotic and dramatic 1976 production of Star Wars, starring Ewan McGregor as Alec Guinness and Hayden Christiansen as David Prowse.
Ewan McGregor looking a lot like Alec GuinnessHayden CHristiansen looking a lot like Dave Prowse
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Sam Foley @samuelfoley.com · 22/09/2026
To add insult to injury, it's full of AI slop images.
A hallucinated man in a suit holding a metal rectangle that has merged with his elbow
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Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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Sam Foley @samuelfoley.com · 13/09/2026
He saw this episode of Star Trek and got confused why we still have two Irelands
Lt. Commander Data brings up "the Irish Unification of 2024" in conversation with Captain Picard
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Sam Foley @samuelfoley.com · 12/09/2026
For maximum efficiency, you need to wait until someone else is really close to succeeding, then feed their intermediate results to the LLM.
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Sam Foley @samuelfoley.com · 12/09/2026
Not my man Gibbs getting relegated to "and others"!
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Lauren Lassabe Shepherd @llassabe.bsky.social · 11/09/2026
Two types of academic correspondence are “apologies for the delay but I’ll need more time” and “hey do you wanna do this thing with me three years from now”
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Sam Foley @samuelfoley.com · 11/09/2026
I can't decide whether the fact that it's a bot makes it more or less funny
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Sam Foley @samuelfoley.com · 11/09/2026
Pros: can sleep in total darkness at any time of day Cons: can sleep in total darkness at any time of day
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Sam Foley @samuelfoley.com · 09/09/2026
This is a really nice post about teaching and giving exams now that LLMs are everywhere. Rather CS-focused, but still interesting generally. ploum.net/2026-01-19-e...
ploum.net
Giving University Exams in the Age of Chatbots
Giving University Exams in the Age of Chatbots par Ploum - Lionel Dricot.
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Sam Foley @samuelfoley.com · 09/09/2026
I deleted my quote tweet of this yesterday because I figured I ought not react too quickly. But man, this is such a naively simplistic view that it's hard to take seriously.
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Sam Foley @samuelfoley.com · 08/09/2026
Hyperparameters aren't enough; we need omniparameters
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Sam Foley @samuelfoley.com · 08/09/2026
Interesting, I'm guessing the first one was written based on the statement Buckmaster posted last night, and the latter is based on the announcement from OpenAI that was posted today. I only saw the first one.
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Sam Foley @samuelfoley.com · 08/09/2026
Perhaps important to note in Buckmaster's statement: "The program this fits into was not started by us nor was it proposed by a Large Language Model." Certainly puts a damper on the "zomg AI is solving all of math" narrative being pushed by OpenAI cims.nyu.edu/~tristanb/st...
cims.nyu.edu
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Sam Foley @samuelfoley.com · 08/09/2026
WSJ's headline unambiguously credits OpenAI, with the subheading characterizing the academic mathematicians as envious sore losers. SciAm takes a much more moderated approach, leaving companies out of the headline and discussing the issue in the article.
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Sam Foley @samuelfoley.com · 08/09/2026
Very interesting to see news outlets seemingly taking sides on the Navier-Stokes priority dispute right from the start.
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Sam Foley @samuelfoley.com · 30/08/2026
Captain: WHAT YOU SAY !!
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Sam Foley @samuelfoley.com · 25/08/2026
This is a great read.
Range Although almost everything before this point seems plausible, if not quite exciting, range is where it all falls apart. Let’s look at a climb scenario. You are sitting on the end of the runway. You advance the throttles forward. The 1.5g of acceleration is approaching that of a Formula 1 car. After a few seconds, the aircraft is airborne and the pilot could pull the nose vertical. For here, the aircraft accelerate and climbs like a rocket. Only faster. After 1 minute, the Dreamjet is at 30,000 feet. The pilot can then level out, turn off the fasten seat belt light, and they configure the aircraft for glide mode, because that is the Dreamjet will become a glider in the next 30 seconds. And with the massive airflow separation coming off the fuselage, the aircraft has a glide ratio of 3.0, which is worse than the space shuttle when landing. From 30,000 feet, the plane could glide for about 17 miles. But hopefully the pilot is skilled and can land on the first approach, because there is no fuel for a go around.
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Thorn @coelliptic.bsky.social · 25/08/2026
here's the aerodynamics of the barbie jet at mach 0.3
someone put the barbie jet into an aerodynamics finite element model and ran it at mach 0.3
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Sam Foley @samuelfoley.com · 25/08/2026
Jedii ("jed-ee-eye")
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Sam Foley @samuelfoley.com · 25/08/2026
I know you do it just to get engagement from dweebs like me, but you've gotta stop writing "Jedis"
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Sam Foley @samuelfoley.com · 24/08/2026
It tends to stay fairly quiet-ish unless there's a lot of CPU utilization. I can usually hear the fan all the time in a quiet room, but it's not loud until I have a task going 100% for a minute or so. I don't monitor the actual temps much.
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Sam Foley @samuelfoley.com · 22/08/2026
Optimist: The cup is half full Pessimist: The cup is half empty Physicist: The cup *was* half full of superfluid Helium-4, but it has climbed the walls of its container and the cup is now empty
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Sam Foley @samuelfoley.com · 21/08/2026
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Sam Foley @samuelfoley.com · 21/08/2026
"How could you do this to me"
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Sam Foley @samuelfoley.com · 19/08/2026
I mean, how can you see a book that's just called "Tubes" and NOT be compelled to read it?
Cover of "Tubes" 2nd Ed. by Alfred Gray
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Sam Foley @samuelfoley.com · 19/08/2026
These are the kinds of diagrams I want in the math books I read Taken from "Tubes", 2nd Ed. by Alfred Gray
Excerpt from "Tubes" 2nd Ed. by Alfred Gray:

"Import Remarks:
(1) If P has a boundary, then
T(P,r) =/= {m in M | distance(m,P) <= r},
because the ends of the set on the right-hand side must be excluded to get the left-hand side"
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Sam Foley @samuelfoley.com · 18/08/2026
Some fun with parallel curves
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Sam Foley @samuelfoley.com · 09/08/2026
Shrek emerges from his outhouse
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Sam Foley @samuelfoley.com · 07/08/2026
Bobson Dugnutt
List of American-sounding baseball player names from the 90s Japanese game Fighting Baseball. Bobson Dugnutt is one of the listed names.
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Sam Foley @samuelfoley.com · 07/08/2026
He likes grocery day
Lenny the tuxedo cat sits upon a pile of Target paper bags.
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Sam Foley @samuelfoley.com · 30/07/2026
Do you really want to mail forever?
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Sam Foley @samuelfoley.com · 28/07/2026
Good on the admin for making people do the training, though. If that's how easy it is to trick people, oof we are in trouble.
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Sam Foley @samuelfoley.com · 28/07/2026
Hopkins sent out a fairly obvious phishing attempt as a training email, and it's rather distressing that there's now a thread in the JHU subreddit full of people complaining about getting caught by it and being required to take anti-phishing training.
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CMU Mellon College of Science @cmuscience.bsky.social · 23/07/2026
CMU biophysicists are flipping the script on cell membrane dynamics. They’ve developed a new theoretical framework that links membrane stress to lipid flip-flop, uncovering a key driver of membrane asymmetry. 🧪⚛️ www.cmu.edu/mcs/news-eve...
cmu.edu
CMU Researchers Capture the Randomness of Lipid Flip-Flopping
Cell membranes are dynamic, two-sided structures made of asymmetric lipid layers. While lipids can randomly flip-flop from one layer to the other, membrane proteins sort lipids between the two sides. ...
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Sam Foley @samuelfoley.com · 17/07/2026
static.klipy.com
Andy Dwyer Parks And Rec
Alt: Andy Dwyer Parks And Rec: "New band name, I call it!"
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Sam Foley @samuelfoley.com · 17/07/2026
Oh boy, I better go find a phone book!
A poster page in the back of a book: 
"For more adventures of Star Wars: X-Wing Rogue Squadron, head to your local comic-book specialty store! You'll find it listed under 'comic books' in your local telephone directory!"
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Sam Foley @samuelfoley.com · 16/07/2026
Not enough actual people working at CMU to have a real photo for the piece?
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Sam Foley @samuelfoley.com · 14/07/2026
Good to hear that some things never change
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