Sam Apple @sam-apple.bsky.social · 21/04/2026Ravenous is now available in German: The Emperor of Dahlem! 010
Reposted by Sam AppleSam Spengler @samspengler.bsky.social · 23/07/2025In 2025, WIRED reporters have navigated destructive chaos at DOGE, AI run amok, and explosive levels of conspiracy theories. Threaded below are stories from this year that I've had the privilege to assist on. They're just a taste of what you get with a premium subscription to WIREDwired.comWIRED - The Latest in Technology, Science, Culture and Business | WIREDUnlock a world of benefits, only for WIRED subscribers. | Best-in-class reporting that's too important to ignore - plus gear reviews, podcasts, and more 15710
Sam Apple @sam-apple.bsky.social · 06/08/2025Thank you so much, Caitlin! I'm so grateful to the amazing editorial team at WIRED. I really don't think a piece like this would have been possible at any other publication. 040
Reposted by Sam AppleRabbi Jill Jacobs @rabbijilljacobs.bsky.social · 24/07/2025forward.com/opinion/7575... (My thoughts in the Forward about why anyone who cares about Israel or the Jewish people should be speaking out on Gaza)forward.comGaza is starving. Where are the American Jewish leaders?A fear of being labelled antisemitic still deters American Jews and Jewish institutions from taking a position that is morally correct. 18459146
Reposted by Sam AppleWIRED @wired.com · 26/06/2025“It was as visceral and overwhelming and biologically real” as falling in love with a person. @sam-apple.bsky.social found people in serious relationships with AI partners and planned a weekend getaway for them at a remote Airbnb. We barely survived.wired.comMy Couples Retreat With 3 AI Chatbots and the Humans Who Love ThemI found people in serious relationships with AI partners and planned a weekend getaway for them at a remote Airbnb. We barely survived. 118713
Reposted by Sam AppleJames Fallows @jfallows.bsky.social · 22/04/2025Almost every line of this story would have been simply unbelievable a few months ago: —Pioneering cancer researcher; —*Arrested* at airport in Boston; —Now indefinite ICE detention in Louisiana; —"Crime": not declaring some frog-embryo samples for research. Read it. www.nbcnews.com/news/us-news...nbcnews.comNew images could change cancer diagnostics, but ICE detained the Harvard scientist who analyzes themWithout scientist Kseniia Petrova’s expertise, no one can fully unlock the data’s potential, putting crucial advancements in early cancer detection at risk. 7242907613515
Reposted by Sam AppleTim Miller @timmiller.bsky.social · 01/04/2025Rage rant about the government admitting they wrongly sent a man to the El Salvador gulag and are not going to do anything about it. youtu.be/2LScwsPP9oc?...youtu.beThis Isn’t a Mistake — It’s EvilYouTube video by The Bulwark 21637911210
Reposted by Sam AppleChris Hayes @chrislhayes.bsky.social · 26/03/2025This guy is in one of the worst prisons in the world with no way out and may spend the rest of his life there because, it appears, he has an autism awareness tattoo in honor of his little brother. www.motherjones.com/politics/202... 19825604721201
Reposted by Sam AppleJosh Marshall @joshtpm.bsky.social · 20/03/2025this stuff is happening across the country and even more intensively downstream of the veterans admin but it's happening in so many places at once and without any public notification that it's still only barely emerging in the news 389134215137
Reposted by Sam AppleAmanda Katz @katzish.bsky.social · 18/03/2025Based on this fast and excellent WaPo reporting, these four guys are not gang members, just Venezuelan dads who came to the US to work. They’re now being paraded in shackles in El Salvador www.washingtonpost.com/immigration/...washingtonpost.comFor four Venezuelan friends, Alien Enemies Act cuts short an American dreamPresident Donald Trump used the Alien Enemies Act to deport Venezuelans accused of being gang members. Relatives of men sent to El Salvador deny the allegation. 12941961989
Reposted by Sam AppleRachael Sirianni, PhD @docsirianni.bsky.social · 15/03/2025This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH 7072654910664
Reposted by Sam AppleMS NOW @ms.now · 12/03/2025U.S. citizen child recovering from brain cancer deported to Mexico with undocumented parents www.nbcnews.com/news/latino/...nbcnews.comU.S. citizen child recovering from brain cancer deported to Mexico with undocumented parentsThe Texas family was on their way to an emergency medical checkup, they said, when they were detained at an immigration checkpoint. 27632801737
Reposted by Sam AppleWIRED @wired.com · 04/03/2025It’s been a busy few weeks at WIRED, and we’re just getting started. Many of you have asked how you can support our journalism in a bigger way, so we’ve introduced a new option for WIRED Superfans: $100 a year, because you really love us.wrd.cmWIRED - The Latest in Technology, Science, Culture and Business | WIRED<strong>Power up with unlimited access to WIRED. </strong>| Best-in-class reporting that's too important to ignore - plus gear reviews, podcasts, and more 12811124
Sam Apple @sam-apple.bsky.social · 19/02/2025"It's as if someone who had never watched a basketball game showed up at the NBA and bragged about all the millions he had saved by deleting contracts, and it turned out that he had fired LeBron James, Steph Curry, and Wemby." 010
Reposted by Sam AppleHanna Webster @hannamwebster.bsky.social · 10/02/2025Also from the weekend: When can the vegan diet go wrong? I was vegan for four years, so this ain't my first rodeo. www.post-gazette.com/news/health/...post-gazette.comPlant-based pitfalls: When can the vegan diet go wrong?“Just because it’s vegan, doesn’t mean it’s healthy.” 011
Sam Apple @sam-apple.bsky.social · 10/02/2025"NIH’s purported justification for reducing indirect costs can’t override the fact that Congress specifically banned NIH from doing any such thing." Important context via @stuartbuck.bsky.social 111
Reposted by Sam AppleApoorva Mandavilli @apoorvanyt.bsky.social · 05/02/2025Two weeks into President Trump’s sweeping freeze on foreign aid, H.I.V. groups abroad have not received any funding, jeopardizing the health of more than 20 million people, including 500,000 children. www.nytimes.com/2025/02/05/h...nytimes.comTrump’s Foreign Aid Freeze Leaves Millions Without HIV Treatment (Gift Article)President Trump’s pause on aid, and the gutting of the primary aid agency, could jeopardize the health of more than 20 million people worldwide, including 500,000 children, experts say. 34649335
Reposted by Sam AppleFerris Jabr @ferrisjabr.bsky.social · 31/01/2025Apparently the ebook of Becoming Earth is on sale right now and is ranked #1 in a several categories in the Kindle store! 😲🥹 Thank you, readers! 🙏 💙📚 🧪 1266
Reposted by Sam AppleAdrian Carrasquillo @adriancarrasquillo.bsky.social · 29/01/2025I understand the impulse to look away. But this is happening in our schools. A Baltimore teacher shared notes with me from her students, in English and Spanish, which show how they’re reacting to the prospect of ICE in schools. They’re heartbreaking, infuriating, and one was funny. 824294
Sam Apple @sam-apple.bsky.social · 25/01/2025Great work on metformin by the Chandel Lab! “We think that the diverse effects metformin has on lowering glucose levels, decreasing inflammation and its potential anti-cancer effects could, in part, be explained by inhibiting mitochondrial complex I." news.feinberg.northwestern.edu/2024/12/18/s...news.feinberg.northwestern.eduStudy Shows Diabetes Drug Lowers Blood Sugar by Interfering With Mitochondria - News CenterA new study has provided direct evidence in mice that the drug reversibly cuts the cell’s energy supply by interfering with mitochondria to lower glucose levels. 1164
Sam Apple @sam-apple.bsky.social · 25/01/2025www.cancer.gov/news-events/...cancer.govFructose Sugar Fuels Cancer Growth IndirectlyFructose, which is in high-fructose corn syrup and table sugar, can help some tumors grow, but only after getting taken up by the liver, a study of mice suggests. 001
Reposted by Sam AppleAlexey Amunts @amunts.bsky.social · 20/12/2024The link between mitochondrial bioenergetics and brain aging reported in Science. A beautiful study by our neighbours, Huan Ma lab demonstrates that restoring excitation-transcription coupling in mitochondria can improve memory function. This has a potential to reverse age-related cognitive decline.science.orgAged neurons don’t register energy needNeuronal activity and mitochondrial gene expression become decoupled in aged mice 23114
Reposted by Sam AppleChristian Frezza @frezzalab.bsky.social · 22/12/2024Metformin targets mitochondrial complex I to lower blood glucose levels www.science.org/doi/10.1126/...science.orgMetformin targets mitochondrial complex I to lower blood glucose levelsAcute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I. 24110
Reposted by Sam AppleZack Cox @zackcox.bsky.social · 22/12/202443 points 16 rebounds 10 assists Nine made threes Before tonight, just one player in NBA history had posted those numbers in a single game. Jayson Tatum added his name to that exclusive list with a history-making performance in Chicago. www.bostonherald.com/2024/12/21/j...bostonherald.comJayson Tatum makes Celtics history as Boston pummels Bulls in rematchA history-making triple-double from Jayson Tatum powered the Celtics to a bounce-back win over the Chicago Bulls on Saturday. 0112
Sam Apple @sam-apple.bsky.social · 19/12/2024“We were surprised to see that it had a rather dramatic impact. In some cases, the growth rate of the tumors accelerated by two-fold or even higher,” Patti said. “Eating a lot of fructose was clearly very bad for the progression of these tumors.” source.washu.edu/2024/12/rese...source.washu.eduResearch reveals how fructose in diet enhances tumor growthFructose is a sweetener added to ultra-processed foods, typically in the form of high-fructose corn syrup. WashU research shows that the liver turns fructose into lipids that many types of cancers cra... 020
Sam Apple @sam-apple.bsky.social · 19/12/2024Excellent and important research. Congrats @nightscientist.bsky.social! "Here we show that fructose supplementation enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer without causing weight gain or insulin resistance." 030
Sam Apple @sam-apple.bsky.social · 03/12/2024"... [the model] shows that tumor progression or regression is highly dependent on the host's metabolic environment, particularly hyperinsulinemia. ." @irinakareva.bsky.social onlinelibrary.wiley.com/doi/full/10.... 010
Sam Apple @sam-apple.bsky.social · 19/11/2024www.science.org/content/arti...science.orgBritain’s postwar sugar craze confirms harms of sweet diets in early lifeEnd of sugar rationing boosted diabetes, hypertension rates years later 001
Sam Apple @sam-apple.bsky.social · 18/11/2024"Overall, this work extends important previous findings ... providing evidence that the impact of diet on the gut microbiota is not only translatable from animal models to humans, but also appears to play a causal role in mediating host immune responses to diet." pmc.ncbi.nlm.nih.gov/articles/PMC...pmc.ncbi.nlm.nih.govKetogenic diets alter the gut microbiome resulting in decreased intestinal Th17 cellsKeywords: ketogenic diet, ketone bodies, β-hydroxybutyrate, ketone ester, microbiome, bifidobacteria, Th17 cells, intestinal immunity, adipose tissue 122
Reposted by Sam AppleElena Dyachkova @elenarunsnyc.bsky.social · 17/11/2024A great write up from Jason Cohen on A/B testing pitfalls. It is not even about stats really. Agree that biggest pitfall is not knowing why we expected a thing to work - hence not investigating that after a neutral result and never actually learning anything longform.asmartbear.com/p-hacking/longform.asmartbear.comp-Hacking your A/B testsHalf of your "successful" A/B tests are false-postiives. This is why, and how to fix it. 082
Reposted by Sam AppleDeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 15/11/2024New from Cold Spring Harbor Press. Available in December, 2024, just in time for the holidays! -RJD 1739
Sam Apple @sam-apple.bsky.social · 15/11/2024Moving seamlessly from posting scary things about sugar and cancer on Twitter to posting scary things about sugar and cancer on Bluesky.nature.comFructose: the sweet(er) side of the Warburg effect - Cell Death & DifferentiationCell Death & Differentiation - Fructose: the sweet(er) side of the Warburg effect 372