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Sam Apple

@sam-apple.bsky.social
618 followers 195 following 23 posts

Faculty, Johns Hopkins Science Writing; Author of Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection ☘️Jayson Tatum's co-author☘️

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Sam Apple @sam-apple.bsky.social · 21/04/2026
Ravenous is now available in German: The Emperor of Dahlem!
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Sam Spengler @samspengler.bsky.social · 23/07/2025
In 2025, WIRED reporters have navigated destructive chaos at DOGE, AI run amok, and explosive levels of conspiracy theories. Threaded below are stories from this year that I've had the privilege to assist on. They're just a taste of what you get with a premium subscription to WIRED
wired.com
WIRED - The Latest in Technology, Science, Culture and Business | WIRED
Unlock a world of benefits, only for WIRED subscribers. | Best-in-class reporting that's too important to ignore - plus gear reviews, podcasts, and more
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Sam Apple @sam-apple.bsky.social · 06/08/2025
Thank you so much, Caitlin! I'm so grateful to the amazing editorial team at WIRED. I really don't think a piece like this would have been possible at any other publication.
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Rabbi Jill Jacobs @rabbijilljacobs.bsky.social · 24/07/2025
forward.com/opinion/7575... (My thoughts in the Forward about why anyone who cares about Israel or the Jewish people should be speaking out on Gaza)
forward.com
Gaza is starving. Where are the American Jewish leaders?
A fear of being labelled antisemitic still deters American Jews and Jewish institutions from taking a position that is morally correct.
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Sam Apple @sam-apple.bsky.social · 08/07/2025
Thanks for sharing, @longreads.com!
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Sam Apple @sam-apple.bsky.social · 30/06/2025
My new article for WIRED...
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WIRED @wired.com · 26/06/2025
“It was as visceral and overwhelming and biologically real” as falling in love with a person. @sam-apple.bsky.social found people in serious relationships with AI partners and planned a weekend getaway for them at a remote Airbnb. We barely survived.
wired.com
My Couples Retreat With 3 AI Chatbots and the Humans Who Love Them
I found people in serious relationships with AI partners and planned a weekend getaway for them at a remote Airbnb. We barely survived.
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Sam Apple @sam-apple.bsky.social · 26/06/2025
I wrote about AI companions for Wired...
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James Fallows @jfallows.bsky.social · 22/04/2025
Almost every line of this story would have been simply unbelievable a few months ago: —Pioneering cancer researcher; —*Arrested* at airport in Boston; —Now indefinite ICE detention in Louisiana; —"Crime": not declaring some frog-embryo samples for research. Read it. www.nbcnews.com/news/us-news...
nbcnews.com
New images could change cancer diagnostics, but ICE detained the Harvard scientist who analyzes them
Without scientist Kseniia Petrova’s expertise, no one can fully unlock the data’s potential, putting crucial advancements in early cancer detection at risk.
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Sam Apple @sam-apple.bsky.social · 03/04/2025
Been there...
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Tim Miller @timmiller.bsky.social · 01/04/2025
Rage rant about the government admitting they wrongly sent a man to the El Salvador gulag and are not going to do anything about it. youtu.be/2LScwsPP9oc?...
youtu.be
This Isn’t a Mistake — It’s Evil
YouTube video by The Bulwark
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Chris Hayes @chrislhayes.bsky.social · 26/03/2025
This guy is in one of the worst prisons in the world with no way out and may spend the rest of his life there because, it appears, he has an autism awareness tattoo in honor of his little brother. www.motherjones.com/politics/202...
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Josh Marshall @joshtpm.bsky.social · 20/03/2025
this stuff is happening across the country and even more intensively downstream of the veterans admin but it's happening in so many places at once and without any public notification that it's still only barely emerging in the news
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Amanda Katz @katzish.bsky.social · 18/03/2025
Based on this fast and excellent WaPo reporting, these four guys are not gang members, just Venezuelan dads who came to the US to work. They’re now being paraded in shackles in El Salvador www.washingtonpost.com/immigration/...
washingtonpost.com
For four Venezuelan friends, Alien Enemies Act cuts short an American dream
President Donald Trump used the Alien Enemies Act to deport Venezuelans accused of being gang members. Relatives of men sent to El Salvador deny the allegation.
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Rachael Sirianni, PhD @docsirianni.bsky.social · 15/03/2025
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
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MS NOW @ms.now · 12/03/2025
U.S. citizen child recovering from brain cancer deported to Mexico with undocumented parents www.nbcnews.com/news/latino/...
nbcnews.com
U.S. citizen child recovering from brain cancer deported to Mexico with undocumented parents
The Texas family was on their way to an emergency medical checkup, they said, when they were detained at an immigration checkpoint.
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WIRED @wired.com · 04/03/2025
It’s been a busy few weeks at WIRED, and we’re just getting started. Many of you have asked how you can support our journalism in a bigger way, so we’ve introduced a new option for WIRED Superfans: $100 a year, because you really love us.
wrd.cm
WIRED - The Latest in Technology, Science, Culture and Business | WIRED
<strong>Power up with unlimited access to WIRED. </strong>| Best-in-class reporting that's too important to ignore - plus gear reviews, podcasts, and more
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Sam Apple @sam-apple.bsky.social · 19/02/2025
"It's as if someone who had never watched a basketball game showed up at the NBA and bragged about all the millions he had saved by deleting contracts, and it turned out that he had fired LeBron James, Steph Curry, and Wemby."
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Hanna Webster @hannamwebster.bsky.social · 10/02/2025
Also from the weekend: When can the vegan diet go wrong? I was vegan for four years, so this ain't my first rodeo. www.post-gazette.com/news/health/...
post-gazette.com
Plant-based pitfalls: When can the vegan diet go wrong?
“Just because it’s vegan, doesn’t mean it’s healthy.”
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Sam Apple @sam-apple.bsky.social · 10/02/2025
"NIH’s purported justification for reducing indirect costs can’t override the fact that Congress specifically banned NIH from doing any such thing." Important context via @stuartbuck.bsky.social
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Apoorva Mandavilli @apoorvanyt.bsky.social · 05/02/2025
Two weeks into President Trump’s sweeping freeze on foreign aid, H.I.V. groups abroad have not received any funding, jeopardizing the health of more than 20 million people, including 500,000 children. www.nytimes.com/2025/02/05/h...
nytimes.com
Trump’s Foreign Aid Freeze Leaves Millions Without HIV Treatment (Gift Article)
President Trump’s pause on aid, and the gutting of the primary aid agency, could jeopardize the health of more than 20 million people worldwide, including 500,000 children, experts say.
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Ferris Jabr @ferrisjabr.bsky.social · 31/01/2025
Apparently the ebook of Becoming Earth is on sale right now and is ranked #1 in a several categories in the Kindle store! 😲🥹 Thank you, readers! 🙏 💙📚 🧪
Screenshot showing Becoming Earth ranked #1 in Environmentalism, Environmental Science, and Conservation in the Kindle Store
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Adrian Carrasquillo @adriancarrasquillo.bsky.social · 29/01/2025
I understand the impulse to look away. But this is happening in our schools. A Baltimore teacher shared notes with me from her students, in English and Spanish, which show how they’re reacting to the prospect of ICE in schools. They’re heartbreaking, infuriating, and one was funny.
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Sam Apple @sam-apple.bsky.social · 25/01/2025
Great work on metformin by the Chandel Lab! “We think that the diverse effects metformin has on lowering glucose levels, decreasing inflammation and its potential anti-cancer effects could, in part, be explained by inhibiting mitochondrial complex I." news.feinberg.northwestern.edu/2024/12/18/s...
news.feinberg.northwestern.edu
Study Shows Diabetes Drug Lowers Blood Sugar by Interfering With Mitochondria - News Center
A new study has provided direct evidence in mice that the drug reversibly cuts the cell’s energy supply by interfering with mitochondria to lower glucose levels.
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Sam Apple @sam-apple.bsky.social · 25/01/2025
www.cancer.gov/news-events/...
cancer.gov
Fructose Sugar Fuels Cancer Growth Indirectly
Fructose, which is in high-fructose corn syrup and table sugar, can help some tumors grow, but only after getting taken up by the liver, a study of mice suggests.
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Alexey Amunts @amunts.bsky.social · 20/12/2024
The link between mitochondrial bioenergetics and brain aging reported in Science. A beautiful study by our neighbours, Huan Ma lab demonstrates that restoring excitation-transcription coupling in mitochondria can improve memory function. This has a potential to reverse age-related cognitive decline.
science.org
Aged neurons don’t register energy need
Neuronal activity and mitochondrial gene expression become decoupled in aged mice
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Christian Frezza @frezzalab.bsky.social · 22/12/2024
Metformin targets mitochondrial complex I to lower blood glucose levels www.science.org/doi/10.1126/...
science.org
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
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Zack Cox @zackcox.bsky.social · 22/12/2024
43 points 16 rebounds 10 assists Nine made threes Before tonight, just one player in NBA history had posted those numbers in a single game. Jayson Tatum added his name to that exclusive list with a history-making performance in Chicago. www.bostonherald.com/2024/12/21/j...
bostonherald.com
Jayson Tatum makes Celtics history as Boston pummels Bulls in rematch
A history-making triple-double from Jayson Tatum powered the Celtics to a bounce-back win over the Chicago Bulls on Saturday.
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Sam Apple @sam-apple.bsky.social · 19/12/2024
“We were surprised to see that it had a rather dramatic impact. In some cases, the growth rate of the tumors accelerated by two-fold or even higher,” Patti said. “Eating a lot of fructose was clearly very bad for the progression of these tumors.” source.washu.edu/2024/12/rese...
source.washu.edu
Research reveals how fructose in diet enhances tumor growth
Fructose is a sweetener added to ultra-processed foods, typically in the form of high-fructose corn syrup. WashU research shows that the liver turns fructose into lipids that many types of cancers cra...
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Sam Apple @sam-apple.bsky.social · 19/12/2024
Excellent and important research. Congrats @nightscientist.bsky.social! "Here we show that fructose supplementation enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer without causing weight gain or insulin resistance."
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Sam Apple @sam-apple.bsky.social · 03/12/2024
"... [the model] shows that tumor progression or regression is highly dependent on the host's metabolic environment, particularly hyperinsulinemia. ." @irinakareva.bsky.social onlinelibrary.wiley.com/doi/full/10....
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Sam Apple @sam-apple.bsky.social · 19/11/2024
www.science.org/content/arti...
science.org
Britain’s postwar sugar craze confirms harms of sweet diets in early life
End of sugar rationing boosted diabetes, hypertension rates years later
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Sam Apple @sam-apple.bsky.social · 18/11/2024
"Overall, this work extends important previous findings ... providing evidence that the impact of diet on the gut microbiota is not only translatable from animal models to humans, but also appears to play a causal role in mediating host immune responses to diet." pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Ketogenic diets alter the gut microbiome resulting in decreased intestinal Th17 cells
Keywords: ketogenic diet, ketone bodies, β-hydroxybutyrate, ketone ester, microbiome, bifidobacteria, Th17 cells, intestinal immunity, adipose tissue
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Elena Dyachkova @elenarunsnyc.bsky.social · 17/11/2024
A great write up from Jason Cohen on A/B testing pitfalls. It is not even about stats really. Agree that biggest pitfall is not knowing why we expected a thing to work - hence not investigating that after a neutral result and never actually learning anything longform.asmartbear.com/p-hacking/
longform.asmartbear.com
p-Hacking your A/B tests
Half of your "successful" A/B tests are false-postiives. This is why, and how to fix it.
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Noa Dalzell @noadalzell.bsky.social · 17/11/2024
JAYSON TATUM GAME-WINNER
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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 15/11/2024
New from Cold Spring Harbor Press. Available in December, 2024, just in time for the holidays! -RJD
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Sam Apple @sam-apple.bsky.social · 15/11/2024
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Sam Apple @sam-apple.bsky.social · 15/11/2024
Moving seamlessly from posting scary things about sugar and cancer on Twitter to posting scary things about sugar and cancer on Bluesky.
nature.com
Fructose: the sweet(er) side of the Warburg effect - Cell Death & Differentiation
Cell Death & Differentiation - Fructose: the sweet(er) side of the Warburg effect
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