iiinova — where your digital self keeps evolving

Krishanu Saha @sahakris.bsky.social · 29/05/2025

Thrilled to highlight the brilliant work by Mandana Arbab, Zaneta Matuszek, with the Mouro Pinto and Liu labs — another major leap forward for somatic cell gene editing. 👏🧬 Base editing as a therapeutic strategy for repeat expansion diseases @NatureGenet nature.com/articles/s41...

nature.com

130

Krishanu Saha @sahakris.bsky.social · 16/05/2025

@laurensarko.bsky.social gave a great talk at #ASGCT2025: CRISPR-engineered CAR T cells targeting senescence-associated uPAR Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed. #CRISPR #CellTherapy @warfnews.bsky.social

041

Krishanu Saha @sahakris.bsky.social · 13/05/2025

Looking forward to this timely Scientific Symposium and conversation on #CRISPR #GeneEditing at #ASGCT2025! “Who’s Afraid of Off-Target Editing?” 1:30–3:15 PM CT (Room 293–296) With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of @somaticediting Join us! #GenomicMedicine

021

Reposted by Krishanu Saha

Wisconsin Institute for Discovery @widofficial.bsky.social · 13/03/2025

Proud to have you represent!

001

Reposted by Krishanu Saha

Wisconsin Institute for Discovery @widofficial.bsky.social · 06/05/2025

Congrats to Giulia Scimonelli from the @sahakris.bsky.social Lab. The research award, funded by grants from Brittingham Wisconsin Trust, Knapp Bequest, and UW Division for Teaching and Learning, allows her to study T Cell Phenotype Enrichment Through mRNA Delivery for Enhanced CAR-T Manufacturing.

021

Krishanu Saha @sahakris.bsky.social · 12/03/2025

🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate. #CRISPR ghi.wisc.edu/science-is-g...

ghi.wisc.edu

Science is Global: Building Bridges with Dr. Kris Saha – Global Health Institute

050

Krishanu Saha @sahakris.bsky.social · 18/06/2024

🎉 Huge congrats to our newest PhD, Dr. Khajanchi (@omgitsnamita), on her stellar defense! 🌟 She delivered an outstanding presentation on her groundbreaking work developing a tunable #CRISPR genome editing system in human cells. Stay tuned for the preprint! 📄👏

010

Krishanu Saha @sahakris.bsky.social · 18/06/2024

🎓 Today at 10 am CT, join us at the DeLuca Forum or online for @omgitsnamita’s PhD defense on “Regulating Cas9 Genome Editor with Small Molecule Drugs.” 🌟 📍 @DiscoveryBldg 🔗 DM for Zoom link! #CRISPR

000

Krishanu Saha @sahakris.bsky.social · 22/05/2024

Please join me in congratulating @Shankar_K2, Ph.D. on her thesis defense! 🎓 By integrating #CRISPR genome editing w/ cell engineering, Dr. Shankar has crafted programmable cell therapies that are foundational to our lab’s new directions. @CMaT_ERC @UWCarbone @UWMadison_BME

010

Krishanu Saha @sahakris.bsky.social · 14/05/2024

Two PhD defenses this week: Join us! Orchard View, 3280, @WIDiscovery: @dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells @Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.

010

Krishanu Saha @sahakris.bsky.social · 06/05/2024

At #ASGCT2024, we're showcasing advances in non-viral gene editing, CAR T cell therapies, & high-throughput screening. Explore our work on vision restoration, cancer therapy, and ethical challenges in the field. Join us to learn about the latest progress in #GeneTherapy research

010

Krishanu Saha @sahakris.bsky.social · 18/03/2024

Join us this Thursday, Mar 21! A Question of Beginnings: Lab Embryos Between Nature and Synthesis with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more. @GenomeObserv Registration:

000

Krishanu Saha @sahakris.bsky.social · 01/02/2024

More momentum for CRISPR drugs! This time, it’s through direct injection of nanoparticles into the body.

000

Krishanu Saha @sahakris.bsky.social · 27/11/2023

Learn about the first approved #CRISPR drug and our own efforts to build on this breakthrough...tomorrow morning @WPR at 7:30am Central. Call in with your questions: 800-642-1234 @WIDiscovery @uwsmph @UWMadEngr @somaticediting @CMaT_ERC

000

Krishanu Saha @sahakris.bsky.social · 16/11/2023

The first authorized medicine for the #CRISPR field! The US FDA decision is likely to come next month. We are all hoping that post-market/approval data is shared and the durability of efficacy is at least many years, as seen in the clinical trials. ⁦

000

Krishanu Saha @sahakris.bsky.social · 10/11/2023

Finding resonance with many others thinking about global governance of emerging tech here at the #ParisPeaceForum2023. Come see our roundtable discussion on #CRISPR genome editing tomorrow.

000

Krishanu Saha @sahakris.bsky.social · 07/11/2023

It’s been a joy to develop & teach this hands-on #CRISPR lab course for @UWMadEngr. Read about our journey here. Our teaching assistants - Jamie, Anna, and @smerchette - provided invaluable input, and the students are quickly becoming expert gene editors!

000

Krishanu Saha @sahakris.bsky.social · 31/10/2023

Here is an excellent and ongoing discussion of a #CRISPR gene-edited cell therapy on the brink of approval. An important guidepost for our in vivo somatic editing efforts @somaticediting

000

Krishanu Saha @sahakris.bsky.social · 02/10/2023

Congratulations to all the 2023 JITC Best Paper Award Recipients! Especially to former Ph.D. students in our @UWMadison lab: @kpmueller1 + @NicoleJPiscopo (w/@CapitiniMD @UWCarbone @CMaT_ERC) for Best Immune Cell Therapies & Immune Cell Engineering Paper

000

Krishanu Saha @sahakris.bsky.social · 26/09/2023

We are hiring! Join the UW-Madison Biomedical Engineering department as a faculty member in a vibrant research community. 👇

000

Krishanu Saha @sahakris.bsky.social · 01/09/2023

The ecosystem for biotech here in Madison and Wisconsin is on the rise… @UWCarbone @UWMadison @Forward_BIO

000

Krishanu Saha @sahakris.bsky.social · 26/07/2023

Our new @somaticediting article describing an unexpected distribution of #CRISPR genome editing in the brain. These new delivery vectors can travel in surprising ways within tissues after injection. With Emborg, Levine, @GongShaoqin @uwsmph @UWMadEngr

000

Krishanu Saha @sahakris.bsky.social · 13/07/2023

Happy to participate as an expert for this excellent @USGAO report on the applications, challenges, and policy options for regenerative medicine. Lots of exciting work ahead... #CellTherapy #GeneTherapy #CRISPR @NASEM_Health @CMaT_ERC @somaticediting

000

Krishanu Saha @sahakris.bsky.social · 12/07/2023

We are lucky to have @danielevanbauer visit us on Monday! Join us at noon for his seminar on #CRISPR gene editing of blood stem cells. @UW_CHGPM @uwsmph @UWMadEngr @UWCarbone @UWMadScience @UWSCRMC @UWMadison_CGSI @WIDiscovery

000

Krishanu Saha @sahakris.bsky.social · 25/06/2023

🔬🧬 Join our groundbreaking journey as we pave the way for in vivo #CRISPR treatments in the clinic! 🌟 Madison, an incredible place to live and a flourishing tech hub, awaits your talent and expertise. 🌇 (thread 1/6 for two positions)

000

Krishanu Saha @sahakris.bsky.social · 30/05/2023

2023 Camp Champions: Jishnu Saha | Camp Casco

000

Krishanu Saha @sahakris.bsky.social · 09/03/2023

⁦Thank you @NPR⁩ ⁦@robsteinnews⁩ for covering this important #HGEsummit and highlighting contributions from ⁦our growing @GenomeObserv⁩ efforts. ⁦@UWMadison⁩ ⁦@ASU⁩ ⁦@HarvardSTS⁩ #CRISPR

000

Krishanu Saha @sahakris.bsky.social · 07/03/2023

The @somaticediting program and toolkit highlighted internationally here at #HGESummit by @ncats_nih_gov Director, Dr. Joni Rutter. Check out the data in the toolkit here:

000

Krishanu Saha @sahakris.bsky.social · 12/02/2023

Hiring! Looking for scientists and project managers - from academia and/or industry - who want to develop the next generation of #CRISPR cell/gene therapies. We have active grants aiming to move new nonviral drug candidates into first-in-human clinical trials. Please circulate.

000

Krishanu Saha @sahakris.bsky.social · 04/01/2023

Could #AI, data science, & systems thinking improve regenerative medicine? @NASEM_Health provides a vision here for incorporating these advances. w/Anne Plant, Kathy Tsokas, @SarahBeachy1 @KrishRoyLab @ClaudiaZylber @NicoleJPiscopo @SNSchumm @CMaT_ERC

000

Krishanu Saha @sahakris.bsky.social · 03/01/2023

Can the differences in our genes affect CRISPR drugs? Yes, and I discuss beautiful work on human genetic diversity in @NatureGenet by Cancellieri, @lucapinello, Dan Bauer, @shengdarqtsai+colleagues @somaticediting

000

Krishanu Saha @sahakris.bsky.social · 19/12/2022

Very happy to see our trainees get their well-deserved platform. More about her story is here:

000

Krishanu Saha @sahakris.bsky.social · 15/12/2022

#CRISPR editing of the brain...without viral vectors! We can deliver to neurons well via direct injection. Results independently replicated by a 3rd-party testing center @somaticediting @jacksonlab. @Musing_Naiad @Roy_Lab_Thinks @WIDiscovery @WARF_News

000

Krishanu Saha @sahakris.bsky.social · 07/12/2022

What an honor to mentor ⁦@Musing_Naiad⁩ on her journey! ⁦She is an invaluable member of and enriches our ⁦@somaticediting⁩ ⁦@WIDiscovery ⁦@UWMadison⁩ communities everyday.

000

Krishanu Saha @sahakris.bsky.social · 07/10/2022

Save the date! Join the @NASEM_Health #RegenMedForum on November 15 for a workshop, "Training the #RegenerativeMedicine Workforce for the Future". Register now:

010

Krishanu Saha @sahakris.bsky.social · 14/09/2022

Here is a nice summary of our T cell immunotherapy research with @CapitiniMD. We are moving closer to the clinic! This work was led by fantastic former doctoral students @kpmeuller @NicoleJPiscopo.

000

Krishanu Saha @sahakris.bsky.social · 06/09/2022

We're delighted to welcome @shengdarqtsai to campus this week. Please come check out his @UWMadison_CGSI seminar in person or virtually: Thursday 9/8 1:30 pm CDT CRISPR Genome Editing Technologies for Therapeutics @UWMadison @uwsmph @UW_CHGPM @somaticediting DM me for the link

000

Krishanu Saha @sahakris.bsky.social · 22/04/2022

Hear about our latest progress with T cells in @kpmueller1's @CMB_UWMadison defense on Monday. DM me for the Zoom link.

000

Krishanu Saha @sahakris.bsky.social · 22/04/2022

Join us to think through new directions for synthetic biology to improve heart, lung, blood, and sleep (HLBS) health. @nih_nhlbi Virtual Workshop in May with a fantastic group of speakers. Register for free here: draft agenda below

000

Krishanu Saha @sahakris.bsky.social · 15/01/2022

The molecular engineering in this article by the Maris lab and @yarmo111 is 🔥🔥🔥. One more reason to establish flexible manufacturing platforms for edited T cell immunotherapies. @CMaT_ERC

000

Krishanu Saha @sahakris.bsky.social · 06/12/2021

Congratulations, officially. Excited to see what you do next!

000

Krishanu Saha @sahakris.bsky.social · 30/09/2021

Finished an energizing @CMaT_ERC retreat today! A special day for the lab as @smerchette (with @melissa_kinney) @Shankar_K2 @kpmueller1 and Dan all receiving recognition today. Congratulations to all of these fantastic students! @WIDiscovery @UWMadison_BME @CMB_UWMadison

000

Krishanu Saha @sahakris.bsky.social · 22/09/2021

A worthy read, especially for practicing scientists who just want “to follow the science” (i.e., themselves) on policy matters

000

Krishanu Saha @sahakris.bsky.social · 10/09/2021

Tune in to @centraltimewpr to hear me discuss the *new* human genome and gene editing in about an hour (3pm Central):

000

Krishanu Saha @sahakris.bsky.social · 09/09/2021

Looking to control #CRISPR genome editing for therapeutic purposes? Check out our new @MolTherapy Review written by @omgitsnamita and me. Thank you to @somaticediting @CMaT_ERC, in particular @Roy_Lab_Thinks, for very helpful discussions.

000

Krishanu Saha @sahakris.bsky.social · 01/09/2021

Does anyone’s circadian rhythm in the summer align with 7:45am-2:45pm? Certainly not my kids this morning for their first day of school…

000

Krishanu Saha @sahakris.bsky.social · 03/08/2021

Congratulations🍾 for a successful doctoral defense, Dr. Kaivalya Molugu @KaivalyaMolugu! #WomenInScience a huge thanks to the committee, her local and global (🇮🇳) support network, and @WIDiscovery @UWSCRMC @CMaT_ERC @NIGMS

000

Krishanu Saha @sahakris.bsky.social · 30/07/2021

Now online & Open Access thanks to #SubscribeToOpen! Vol 23 of the Annual Review of Biomedical Engineering includes our article brilliantly written by @Amr_Abdeen, @itsbcos, @gersbach, & myself about #CRISPR, biomaterials, and genome editing @AnnualReviews

010