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Safe Khan

@safekhan.bsky.social

9 followers 18 following 3 posts

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Safe Khan @safekhan.bsky.social · 10/09/2025

Thank you to everyone who supported, discussed, and encouraged this work!

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Safe Khan @safekhan.bsky.social · 10/09/2025

In our study, we show that critical point drying (CPD), a resin-free sample prep method, enhances contrast in X-ray phase-contrast imaging of brain tissue, with largely preserving ultrastructure.  ✅ Compatible with femtosecond laser & plasma-FIB milling ✅ Effective for stained and unstained tissue

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Safe Khan @safekhan.bsky.social · 10/09/2025

Our pre-print is out! Critical point drying of brain tissue for x-ray phase contrast imaging. @apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social @carlesbosch.bsky.social @esrf.fr @crick.ac.uk bioarXiv: doi.org/10.1101/2025...

doi.org

Critical point drying of brain tissue for X-ray phase contrast imaging

X-ray phase contrast tomography is emerging as a powerful method for imaging large volumes of brain tissue at sub-cellular resolution. However, current sample preparation methods are largely inherited...

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