iiinova — where your digital self keeps evolving

Reposted by Ryo Mizuuchi

Will Ratcliff @wcratcliff.bsky.social · 15/09/2026

12/17 Origin of Life: how did interacting molecules become organisms capable of evolution? Discussion leader: Loren Williams (@lorendw.bsky.social). With Sarah Maurer and Ryo Mizuuchi (@ryomizuuchi.bsky.social).

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Reposted by Ryo Mizuuchi

Will Ratcliff @wcratcliff.bsky.social · 15/09/2026

1/17 Submissions are now open for the 2027 Microbial Population Biology GRC! We expect this meeting to be extraordinarily oversubscribed. If you want to come, time is of the essence--apply ASAP! June 27–July 2 • Andover, NH www.grc.org/microbial-po...

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Reposted by Ryo Mizuuchi

Sam Díaz-Muñoz (they / ella) @sociovirology.bsky.social · 07/08/2026

Kicking off the final day of #SocialViruses26: Ryo Mizuuchi (Waseda University) with "Social evolution of artificial RNA replicators"

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Will Ratcliff @wcratcliff.bsky.social · 13/05/2026

1/23 New preprint! Been thinking about the origin of cellular life. Specifically, how protocells (or *any* compartments) just aren't enough to support the evolution of increasingly complex cells. You gotta de-Darwinize the parts! The ribosome/genome do this. www.biorxiv.org/content/10.6...

biorxiv.org

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Ryo Mizuuchi @ryomizuuchi.bsky.social · 17/04/2026

Happy to share our new paper in @pnas.org! In collaboration with the David Lacoste lab at ESPCI Paris, we combine experiments and modeling to show how mixing-dependent “compositional memory” of compartments shapes replicase (host)–parasite RNA dynamics. www.pnas.org/doi/10.1073/...

pnas.org

Compositional memory matters for early molecular systems | PNAS

The error catastrophe refers to the proliferation of nonfunctional molecules in conditions where molecular replication has low accuracy, which is l...

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Reposted by Ryo Mizuuchi

Edoardo Gianni @edogia.bsky.social · 13/02/2026

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

science.org

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

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Ryo Mizuuchi @ryomizuuchi.bsky.social · 07/11/2025

Happy to share our new review on oligonucleotide chemical evolution on early Earth. We discuss how iterative sequence selection and diversification could have shaped RNA pools, facilitating sequence exploration and the emergence of ribozymes. www.jstage.jst.go.jp/article/biop...

jstage.jst.go.jp

Selection–diversification interplay in oligonucleotide chemical evolution

The emergence of catalytic RNAs (ribozymes) may have set the stage for an “RNA world” preceding protein evolution. The probability of ribozyme emergen …

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Reposted by Ryo Mizuuchi

Will Ratcliff @wcratcliff.bsky.social · 24/06/2025

1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬 www.science.org/doi/full/10....

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Ryo Mizuuchi @ryomizuuchi.bsky.social · 05/05/2025

Lab stargazing night. A sky full of stars and the Milky Way over Mt. Fuji.

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