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Ilya Ruvinsky

@ruvinskyilya.bsky.social
336 followers 295 following 69 posts

Lots: dev bio, neuro, social signals, worms. Some: comments re practice of science, art, nature. Occasionally: something funny.

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Ilya Ruvinsky @ruvinskyilya.bsky.social · 13/02/2025
Dear @dev-journal.bsky.social, do you know what makes your claim of "format-free submission" a LOT less credible? Having in place ridiculously arcane formatting rules for submission! This must change!
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Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 24/01/2025
100% this experience on multiple previous occasions. Sharing in the worm community is outstanding!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 15/01/2025
Here's something astounding: www.nature.com/articles/s41...
nature.com
De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 14/01/2025
Strongly endorse:
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 12/01/2025
A nice piece of work by @wormsrock.bsky.social. Highly recommend! academic.oup.com/genetics/art...
academic.oup.com
Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions?
Abstract. Self-fertile Caenorhabditis nematodes carry a surprising number of Medea elements, alleles that act in heterozygous mothers and cause death or de
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 02/01/2025
Care to estimate the relative frequency of these four categories in 2024? Also, how about A, B, C for Category 4 (Huge, Medium, Minor)?
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 02/01/2025
journals.plos.org/plosbiology/...
journals.plos.org
Meta-analysis of single-cell RNA sequencing co-expression in human neural organoids reveals their high variability in recapitulating primary tissue
Although human neural organoids are commonly used to study brain development, it is unclear how well they replicate the biology of primary tissue. These authors conduct a meta-analysis to compare over...
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 22/12/2024
!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 20/12/2024
Sharp. Thoughtful. Insightful. Probably the best thing you will read about academic publishing today, this week, this month, or this year. DO IT!
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The Map Center @mapcenter.com · 17/12/2024
Hi. I'm Andrew. I own New England's oldest map store because last year I moved across the country after an old guy retired and gave it to me Willy Wonka-style. Visit my store in Rhode Island. www.mapcenter.com
A nerd in a teal sweater holding a stack of books about railroads in front of a wall of framed maps.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 16/12/2024
Stress is bad. Several different stresses can be too much. A relatable experience. @currentbiology.bsky.social www.cell.com/current-biol...
cell.com
Combining multiple stressors blocks bacterial migration and growth
Here, Sharma et al. use microfluidics to simultaneously provide a physical stressor (shear flow) and a chemical stressor (H2O2) to the human pathogen Pseudomonas aeruginosa. The replenishing power of shear flow increases H2O2 effectiveness 50-fold, allowing natural levels of H2O2 to block bacterial migration and growth.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 16/12/2024
@currentbiology.bsky.social does it again! Our environments are considerably more complex than we typically think. Is it really so surprising that there are broad swaths of biology we don't even know about, let alone don't know how to interpret? www.cell.com/current-biol...
cell.com
Latitudinal gradients in air density create invisible topography at sea level, affecting animal flight costs
Air density affects the costs of animal flight. This is well-established for flight at high altitude. Shepard et al. show that changes in air density cause regional differences in flight costs at sea level due to latitudinal temperature gradients. They discuss the implications for species distributions and for global change.
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eric lai @lucksmith.bsky.social · 11/12/2024
Natasha Staller and Gary Ruvkun, from yesterday's ceremony with the King of Sweden! 🏆
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 12/12/2024
I agree that these are serious concerns. To me, the answer to "is it worth it?" strongly depends on whether the assertion "papers get better… but not by much" is true. Do we actually have serious estimates?
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 12/12/2024
This describes the process pretty well.
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John Doench @johndoench.bsky.social · 12/12/2024
We could also have PI fantasy league. +5 points for a glam mag publication, -2 for a Not Discussed R01 application, etc etc. I will workshop this idea in order to find a scoring scheme that alienates everyone on the planet.
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Neil Renic @ncrenic.bsky.social · 10/12/2024
Just had an idea
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Ariel Chipman @chipman-lab.bsky.social · 11/12/2024
New preprint just dropped. This is the first of my "sabbatical papers" - conceptual/synthetic papers trying to address broader questions of body-plan evolution. 1/5 ecoevorxiv.org/repository/v...
ecoevorxiv.org
The Development and Evolution of Arthropod Tagmata
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 10/12/2024
As the Nobel Award Ceremony is about to begin, what a valuable lesson was reminded to us all by the lectures given by Victor Ambros and Gary Ruvkun - some of the best science is done in the spirit of curiosity-driven research and genuine collaboration with friends and colleagues. www.nobelprize.org
nobelprize.org
The official website of the Nobel Prize - NobelPrize.org
Nobel Prize award ceremony
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 06/12/2024
Great study, Ethan! Congratulations!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 06/12/2024
Neurons regulate the germline @odedrechavi.bsky.social @bjornschumacher.bsky.social Impressive!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 06/12/2024
Turns out parental brains are thinking about offspring. @odedrechavi.bsky.social @bjornschumacher.bsky.social @meital.bsky.social Impressive!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 06/12/2024
www.cnn.com/science/aust...
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 05/12/2024
Connectomes of synaptic wiring represent remarkable scientific achievements and are useful research tools. That said, much activity in the nervous system occurs via nonsynaptic signaling that is not represented in connectomes. Check out this review: www.sciencedirect.com/science/arti...
sciencedirect.com
Nonsynaptic encoding of behavior by neuropeptides
A basic tenet of neuroscience is that animal behavior is generated by neural circuits that operate through synaptic transmission. On top of this synap…
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 05/12/2024
That was too close for comfort 😅
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 05/12/2024
1. This does not apply to me because I am an efficient writer 2. Oh no
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Binyam Mogessie ቢንያም ሞገሴ @binyammogessie.bsky.social · 29/11/2024
Chromosome segregation errors are common in the early stages of human embryonic development. Read here our open access commentary on three recent studies of spindle architecture and positioning features that could provide insights into why early embryos are predisposed to aneuploidy. rdcu.be/d1TgG
rdcu.be
On the origin of mitosis-derived human embryo aneuploidy
Nature Communications - Chromosome segregation errors are common in the early stages of human embryonic development. By examining the first mitotic divisions of human embryos using live cell...
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 28/11/2024
Nice piece, @javierapfeld.bsky.social
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 27/11/2024
Make sure to read this wonderful piece by Bruce Wightman who was a major player in the early work that resulted in the 2024 Nobel to Ambros and Ruvkun. journals.biologists.com/dmm/article/...
journals.biologists.com
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine
Summary: The 2024 Nobel Prize in Physiology or Medicine has been awarded for the discovery of miRNAs; the groundwork was laid by investigating the timing of developmental events in nematodes.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 27/11/2024
Worm neurons FTW. Again! Read this paper:
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Patrick Phillips @patrickphillips.bsky.social · 22/11/2024
A reminder for new folks. BlueSky does not have an algorithm to raise posts of interest. It is incumbent upon you to do so via reposting. Liking things only provides feedback to the poster but does not promote the post. The signal to noise ratio is taking a brief beating, so great to help curate.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 22/11/2024
This is what I am here for - quality content helpful in everyday life!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 22/11/2024
Check out this excellent study!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 21/11/2024
See this preprint for an answer to the question i always wanted to know but was afraid to ask!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 21/11/2024
Green line is the same as the red. That's all I care about.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 21/11/2024
Just voicing frustration, knowing that many of you feel this way and some posted it here recently. We owe letters of recommendation to trainees. But what a colossal and inexcusable waste of effort it is to submit the same letter to 15 separate portals. WHY DO WE DO THIS TO OURSELVES?
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 21/11/2024
100%! In fact, we could benefit from other kinds of Hulks here.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 21/11/2024
Check out this interesting study! elifesciences.org/reviewed-pre...
elifesciences.org
Olfactory basis for essential amino acid perception during foraging in Caenorhabditis elegans
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 20/11/2024
Hey, my-not-so-numerous-yet peeps, I thought this was an important article when I was on that other site. I still think so and recommend you read it.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 20/11/2024
Likewise, if the data are not freely available.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 20/11/2024
Ok, this looks nice!
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 19/11/2024
A fancy cappuccino. Top view.
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Ilya Ruvinsky @ruvinskyilya.bsky.social · 10/05/2024
We show that the male pheromone that improves oocyte quality does so by upregulating serotonin, which ups neuronal TGFb, which kicks up Notch in the germline niche. Dwindling neurons-to-germline signaling may be the leading edge of reproductive aging. www.biorxiv.org/content/10.1...
biorxiv.org
The roles of TGFβ and serotonin signaling in regulating proliferation of oocyte precursors and germline aging
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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