iiinova — where your digital self keeps evolving

Reposted by Rubayet Elahi

Sloan Ashton @ashton7sloan.bsky.social · 14/12/2025

How can ICE find a random, undocumented person while they're out shopping or at a restaurant, but an entire university with multiple cameras can't fully describe the Brown University shooter? How could the shooter evade multiple cameras? This clearly isn’t Tom Cruise’s ‘Mission Impossible.’

1322242

Rubayet Elahi @rubayet.bsky.social · 07/12/2025

Functional analysis of pyrimidine biosythesis in #Plasmodium falciparum. We demonstrate multiple other essential enzymes of this pathway, besides DHODH. We also present a titrable metabolic bypass of the pyrimidine biosythesis pathway that can be useful for drug discovery studies targeting the ETC.

111

Reposted by Rubayet Elahi

Ming Tommy Tang @tommytang.bsky.social · 22/10/2025

1/ You did a CRISPR screen. Found top hits that kill cancer cells. You think: this is it. Your next paper. Your next drug. But then…

1122

Reposted by Rubayet Elahi

MRC Unit The Gambia at LSHTM @mrcunitgambia.bsky.social · 09/07/2025

Professor Umberto D’Alessandro, #MRCG Unit Director shares insights on the first malaria medicine approved for babies. “Babies have been systematically excluded from clinical trials assessing the safety and efficacy of antimalarial treatments….” Read more: tinyurl.com/mwftby5h #EndMalaria

tinyurl.com

Expert Comment: First malaria medicine for babies approved | LSHTM

The first malaria treatment specifically developed for newborn babies and young infants has been approved for use. The approval, by Switzerland’s medical agency Swissmedic, of Coartem Baby

086

Rubayet Elahi @rubayet.bsky.social · 16/06/2025

First federal grant submission in the bag! I need a beer and some junk food!

000

Rubayet Elahi @rubayet.bsky.social · 06/05/2025

In this study, we report the minimal tRNA modifying enzymes required for complete apicoplast protein translation. Using comparative genomics we identified a list of enzymes predicted to be in the apicoplast, their localization and functional requirement were validated experimentally validated.

010

Rubayet Elahi @rubayet.bsky.social · 06/05/2025

Plasmodium apicoplast genome contains the fewest known tRNA isotypes, making the apicoplast an ideal model to study minimal translation machinery. Such minimal systems depends heavily on posttranscriptional tRNA modifications for accurate protein translation. @jhmrimalaria.bsky.social 1/2 🧪

sciencedirect.com

Decoding the Minimal Translation System of the Plasmodium falciparum Apicoplast: Essential tRNA-modifying Enzymes and Their Roles in Organelle Maintenance

Post-transcriptional tRNA modifications are essential for accurate and efficient protein translation across all organisms. The apicoplast organelle ge…

120

Reposted by Rubayet Elahi

Kari Debbink @karidebbink.bsky.social · 16/04/2025

Just really grim news from all over. I just want a world that values empathy over hate. We could be addressing climate change or global poverty or any other number of issues, but the US, UK, and others are spending their energy making it legal to harass an already-vulnerable group of people.

0115

Rubayet Elahi @rubayet.bsky.social · 15/04/2025

Congratulations! can't wait to read it in details.

to.read

020

Rubayet Elahi @rubayet.bsky.social · 11/04/2025

A stage III and a IV gametocyte in a red blood cell? That's a first for a gametocytes culture newbie like me! #Plasmodium 🧪

060

Reposted by Rubayet Elahi

EMBO Reports @emboreports.org · 21/03/2025

tRNA lysidinylation is essential for the minimal #translation system in the #Plasmodium falciparum apicoplast. -> www.embopress.org/doi/full/10.... First characterization of a TilS enzyme that functions in an endosymbiotic organelle.

041

Rubayet Elahi @rubayet.bsky.social · 28/02/2025

but but... I don't want my money in the form of taxes to save lives. Simple! 🙄

000

Reposted by Rubayet Elahi

Andy Pekosz @andrewpekosz.bsky.social · 22/02/2025

Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025 www.congress.gov/bill/119th-c...

congress.gov

46886

Reposted by Rubayet Elahi

Magdalena Skipper @magdalenaskipper.bsky.social · 21/02/2025

NIH research grants still frozen despite lawsuits challenging Trump order The administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo 🧪 #AcademicSky @nature.com @natureportfolio.nature.com www.nature.com/articles/d41...

nature.com

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

24025

Reposted by Rubayet Elahi

Jeremy Berg @jeremymberg.bsky.social · 16/02/2025

Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78) I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine 1/n

8799395

Rubayet Elahi @rubayet.bsky.social · 11/02/2025

Good news is Congress is at work! 🤷‍♂️

010

Reposted by Rubayet Elahi

Akhil Vaidya @akhilvaidya.bsky.social · 08/02/2025

The Howard Hughes Medical Institute, a huge funder of biomedical research, has cut a $60-million initiative to boost diversity in science education.

031

Reposted by Rubayet Elahi

dr. kristin d. lane 🔬 @kristindownie.bsky.social · 08/02/2025

Idaho State University has an indirect rate of 44% and also no multi-million $ endowment. We will be devastated by this.

021

Reposted by Rubayet Elahi

Matt Barber @biobarber.bsky.social · 08/02/2025

Executive wants to frame the NIH indirects cut as $4B in savings. But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

nih.gov

Direct Economic Contributions

NIH directly supports the economy through investments in research institutions and job formation.

7244142089

Reposted by Rubayet Elahi

David F. Warner @dwarnersoc.bsky.social · 07/02/2025

⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants. —> Deep budget cuts & program closures coming to a university near you. Is this the break the glass moment for university administrators who have been silent so far about the attack on science?

grants.nih.gov

NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

1002137820

Reposted by Rubayet Elahi

ParasitesRule @parasitesrule.org · 05/02/2025

Do you work on parasites and reside in an LMIC? Consider applying for a 2025 MPM LMIC award. The deadline is March 3rd, 2025—details on the website. www.parasitesrule.com/mpm-xxxvi/tr...

parasitesrule.com

Molecular Parasitology Community - Travelaward2025

Scroll down for the application form

01313

Reposted by Rubayet Elahi

Geoff McFadden @fad1.bsky.social · 25/01/2025

Plastids & mitochondria arose from separate endosymbioses of prokaryotes.Their prokaryotic ancestry makes them susceptible to antibiotics. Antibiotics kill pathogenic protists by targeting their plastids or mitochondria. Here we review the lop sided inheritance. journals.plos.org/plospathogen...

journals.plos.org

Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists

Pathogenic protists are responsible for many diseases that significantly impact human and animal health across the globe. Almost all protists possess mitochondria or mitochondrion-related organelles, ...

0175

Rubayet Elahi @rubayet.bsky.social · 28/12/2024

Hope your cat is okay! We spent $4.5k over 5 days and could save one of ours, best feeling ever. But to this day we are clueless what was the reason.

010

Rubayet Elahi @rubayet.bsky.social · 23/12/2024

These 4 enzymes have been included in all the minimal translation machinery concepts proposed to date. The discovery of only these 4 enzymes in #apicoplast of #Plasmodium puts us a step closer to our big picture of establishing apicoplast as minimal translation model.

010

Rubayet Elahi @rubayet.bsky.social · 23/12/2024

Comparative genomics to identify xm5s2U34 biosythesis pathway enzymes in other apicoplast containing pathogens also show the presence of minimal xm5s2U34 pathway.

100

Rubayet Elahi @rubayet.bsky.social · 23/12/2024

Previously, we reported enzymes required for s2U34, which can occur independently of xm5s2U34. In this body, we identified and characterized two other enzymes that are required for xm5U34 synthesis. Altogether, the apicoplast needs ONLY 4, the fewest, enzymes to make xm5s2U34.

110

Rubayet Elahi @rubayet.bsky.social · 23/12/2024

Now, back to the story! The xm5s2U tRNA modifications are specifically important for the tRNAs with A or U ending anticodons in the shared codon boxes. The biosythesis requires 6 (B subtillis) to 12 (E coli) enzymes. What about in the apicoplast?

130

Rubayet Elahi @rubayet.bsky.social · 23/12/2024

Before going in to details, interesting fact! #apicoplast genome contains the minimal complete set of tRNAs among all known living systems, making it a #good #model to study minimal #translation system. We intend to establish that.

100

Rubayet Elahi @rubayet.bsky.social · 23/12/2024

xm5s2U #tRNA modification is crucial for proper protein #translation, especially in a translation system with minimal components. We have described the players of xm5s2U34 biosythesis in #Plasmodium #apicoplast. Read the story to find out why parasites need this and how we did it. 1/6

120

Rubayet Elahi @rubayet.bsky.social · 12/12/2024

Received very good comments back from all three reviewers! 🤓

000