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Radovan Sebesta

@rsebesta.bsky.social
284 followers 365 following 29 posts

Professor of organic chemistry at Comenius University Bratislava, interested in chirality, catalysis, organometallics, green chemistry, mechanochemistry. I like reading books, playing chess, and walking in nature.

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Radovan Sebesta @rsebesta.bsky.social · 16/09/2026
We showed that mechanochemistry and organocatalysis work well together to afford C-1 deuterated aldehydes and α-deutero acyloins via N-heterocyclic carbene catalysis Dr. Péter Kisszékelyi, Ester Mikuličová, @comeniusuni.bsky.social @chemcomm.rsc.org pubs.rsc.org/cc/article-a...
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Radovan Sebesta @rsebesta.bsky.social · 11/09/2026
Check out our recent article on Recent Progress in Mechanochemical Organocatalysis - European Journal of Organic Chemistry - @chemistryeurope.bsky.social @comeniusuni.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
Recent Progress in Mechanochemical Organocatalysis
Recent progress in the application of organocatalytic transformations under mechanochemical conditions shows excellent compatibility of these two concepts. Both covalent and noncovalent activation mo....
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Radovan Sebesta @rsebesta.bsky.social · 08/09/2026
Not just one step, but the whole synthesis of ruxolitinib was improved through mechanochemistry, microwave irradiation, and green solvents - Chemistry – A European Journal Dr. T. Panaska, Z. Mravkova, K. Vargova @comeniusuni.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
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Radovan Sebesta @rsebesta.bsky.social · 15/07/2026
Speaking about catalytic mechanochemistry at 10th EuChemS European Chemistry Congress in Antwerp #ECC10
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Radovan Sebesta @rsebesta.bsky.social · 04/06/2026
Our newest work on Mechanochemical Aminocarbonylation of Unactivated Arenes Leveraging in Situ Thianthrenation and Using FeBr2(CO)4 as a CO Surrogate | Organic Letters pubs.acs.org/doi/full/10.... @comeniusuni.bsky.social
pubs.acs.org
Mechanochemical Aminocarbonylation of Unactivated Arenes Leveraging in Situ Thianthrenation and Using FeBr2(CO)4 as a CO Surrogate
Here, we present a convergent synthesis of aromatic carboxamides from unactivated arenes using FeBr2(CO)4 as a CO source and the corresponding amine. The reaction involves the in situ formation of are...
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Radovan Sebesta @rsebesta.bsky.social · 01/04/2026
I am happy to share our review on recent advances in mechanochemical metal-catalyzed cross-couplings sciencedirect.com/science/arti... Dr. Suman Yadav, @comeniusuni.bsky.social
sciencedirect.com
Recent Advances in Mechanochemical Metal-Catalyzed Cross-Coupling Reactions
Cross-coupling reactions are key chemical transformations allowing efficient construction of structurally diverse molecules. This review surveys recen…
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Reposted by Radovan Sebesta
RSC Mechanochemistry @rscmechanochem.rsc.org · 27/01/2026
Did you see Franziska Emmerling's Editor's pick? This collection contains some of her favourite RSC Mechanochemistry articles published to date. Read the collection for free: pubs.rsc.org/en/journals/...
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Radovan Sebesta @rsebesta.bsky.social · 20/01/2026
Quisqualic acid is an interesting non-proteinogenic amino acid with applications in medicinal chemistry. Have a look at our detailed account on its synthesis, which was just published in Synthesis @synthesis1969.bsky.social www.thieme-connect.de/products/ejo...
thieme-connect.de
Thieme E-Journals - Synthesis / Abstract
Thieme E-Books & E-Journals
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Reposted by Radovan Sebesta
Science News @scinews.bsky.social · 18/01/2026
Writing is thinking "On the value of human-generated scientific writing in the age of large-language models." www.nature.com/articles/s44...
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Radovan Sebesta @rsebesta.bsky.social · 02/12/2025
I am glad that we could contribute to this interesting project led by prof. Ivan Salitros on magnetically bistable Co(ii) and Fe(ii) complexes published in Inorganic Chemistry Frontiers pubs.rsc.org/en/content/a...
pubs.rsc.org
Magnetically bistable Co(II) and Fe(II) complexes featuring pentyl-decorated pyridyl-benzimidazole ligands: role of isomerism and chirality
Three variants of 2-(pyridine-2-yl)-1H-benzimidazole bidentate ligands, with distinct pentyl substituents (n-pentyl (L1), (2S)-2-methylbutyl (L2S), and (2R)-2-methylbutyl (L2R)), were synthesized and ...
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Radovan Sebesta @rsebesta.bsky.social · 05/11/2025
We report here that Povarov cycloaddition is highly enantioselective under mechanochemical conditions using chiral Bronsted acid catalysts - Chemistry – A European Journal - chemistry-europe.onlinelibrary.wiley.com/doi/full/10.... P. Kisszekelyi, T. Doblejova, E. Rakovsky @comeniusuni.bsky.social
chemistry-europe.onlinelibrary.wiley.com
Mechanochemical Stereoselective Povarov Reaction via Brønsted Acid Organocatalysis
Mechanochemical activation enables the synthesis of chiral tetrahydroquinolines with excellent enantioselectivity and good yield. This asymmetric Povarov reaction is efficiently catalyzed via BINOL-b...
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Radovan Sebesta @rsebesta.bsky.social · 03/11/2025
We have been overcome by our passion for ferrocene and had to make some beautiful ferrocene thioamides via Willgerodt–Kindler Reaction - Eur. J. Org. Chem. - chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... @comeniusuni.bsky.social H. Kabzan, P. Kisszekelyi, J. Filo, M, Cigan, E. Rakovsky
chemistry-europe.onlinelibrary.wiley.com
One‐Pot Synthesis of Ferrocene Thioamides from Ferrocenecarboxaldehyde via the Willgerodt–Kindler Reaction
A series of ferrocene thioamides is synthesized via Willgerodt–Kindler reaction from ferrocenecarboxaldehyde. Two experimental protocols are developed to effectively employ both primary and secondary...
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Radovan Sebesta @rsebesta.bsky.social · 10/10/2025
New issue (Issue 10, October 2025) of #ChemicalPapers (part of Springer Nature family) is now online with 59 interesting papers across various chemistry topics. link.springer.com/journal/1169...
link.springer.com
Chemical Papers
Chemical Papers® is a peer-reviewed journal focusing on basic and applied chemistry and chemical engineering research. Covers a large scope including ...
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Radovan Sebesta @rsebesta.bsky.social · 07/09/2025
Spreading the word that mechanochemistry is great for metal catalyzed cross-couplings and carbonylations at 77. Meeting of chemists in High Tatras
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Radovan Sebesta @rsebesta.bsky.social · 27/08/2025
I am proud to present three new doctors from our group: Dr. Henrich Szabados, Dr. Barbora Zahradnikova, and Dr. Klara Stankovianska. @comeniusuni.bsky.social
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Radovan Sebesta @rsebesta.bsky.social · 20/08/2025
Our newest example of catalytic mechanochemistry - atroposelective organocatalytic synthesis of 1,2'-binaphthalene-3'-carbaldehydes under mechanochemical conditions - now published in RSC Mechanochemistry @comeniusuni.bsky.social, with Henrich Szabados doi.org/10.1039/D5MR...
doi.org
Atroposelective organocatalytic synthesis of 1,2'-binaphthalene-3'-carbaldehydes under mechanochemical conditions
Ball-milling allowed the efficient realization of asymmetric organocatalytic Michael/aldol cascade, which affords 1',2´-dihydro-1,2´-binaphthalene derivatives. These compounds were transformed into ax...
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Radovan Sebesta @rsebesta.bsky.social · 08/07/2025
I always love returning to Switzerland. This time to attend #EuCOMC2025 in Bern and speak about mechanochemical cross-couplings.
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Radovan Sebesta @rsebesta.bsky.social · 23/05/2025
Cordial congratulations to our PhD student Zuzana Mravíková for receiving Dean´s award for the best publication of PhD students for her work published in ChemSusChem 2025, 18, e202402599 (lnkd.in/eWDu5ppB)
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Radovan Sebesta @rsebesta.bsky.social · 16/05/2025
I cordially welcome our new postdoc, Dr. Suman Yadav, have a good time in research group.
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Reposted by Radovan Sebesta
Beilstein-Institut @beilstein-institut.bsky.social · 25/04/2025
The thematic issue “Advances in asymmetric #organocatalysis II” ed. by Radovan Šebesta @rsebesta.bsky.social, @comeniusuni.bsky.social, in the Beilstein Journal of Organic Chemistry is complete ➡️ tinyurl.com/yc24a85y #GreenChemistry #greensolvents #catalysis #DiamondOpenAccess 💎🔓 #BJOC
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Radovan Sebesta @rsebesta.bsky.social · 24/04/2025
I am happy to share that I’ve been recognised as one of the Royal Society of Chemistry’s 2024 outstanding reviewers for @chemcomm.rsc.org . Explore the full list at rsc.li/OutstandingReviewers2024 #RSCPeerReview
rsc.li
Outstanding peer reviewers | Royal Society of Chemistry
Thank you to each and every one of our peer reviewers working tirelessly to ensure that the scientific record is accurate and getting great science into the world.
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Radovan Sebesta @rsebesta.bsky.social · 16/04/2025
It is nice to learn that our work is read. Our article received enough views to be a Top Viewed Article. Read it here onlinelibrary.wiley.com/doi/full/10.... #TopViewedArticle @wiley.com
onlinelibrary.wiley.com
Mechanochemical Radical Boronation of Aryl Diazonium Salts Promoted by Sodium Chloride
Mechanochemically performed boronation of arene diazonium salts is presented. The key feature of this method is NaCl which significantly enhances this procedure. Mechanistic and DFT investigations su...
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Radovan Sebesta @rsebesta.bsky.social · 16/04/2025
Our chapter "Partial Reduction of Enones, Styrenes, and Related Systems" for the upcoming release of Comprehensive Organic Synthesis is published doi.org/10.1016/B978... With Dr. Viktoria Nemethova, @comeniusuni.bsky.social
doi.org
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Radovan Sebesta @rsebesta.bsky.social · 10/04/2025
Mechanochemistry and organometallics - Pd-catalyzed coupling of organozinc pivalates and arene thianthrenium salts go well together as can be seen in our recent work chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... @comeniusuni.bsky.social, T. Carny, M. Mart, M. Blauciak, B. Steinhublova.
chemistry-europe.onlinelibrary.wiley.com
Pd‐Catalyzed Cross‐Coupling of Organozinc Pivalates with Arene Thianthrenium Salts under Ball‐milling Conditions
Cross-coupling reactions are important tools in the synthesis of complex molecules. Here we show that the Pd-catalyzed cross-coupling of aryl zinc pivalates with aryl thianthrenium salts offers a gre...
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Radovan Sebesta @rsebesta.bsky.social · 05/04/2025
Reunion with past and present group members at the occasion of my 20 years at Comenius University
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Reposted by Radovan Sebesta
Feringa Lab @feringalab.bsky.social · 05/03/2025
🧪Here are our current open positions: www.benferinga.com/vacancies/ - PhD on Functional DNA-Rotator Motors - PhD in the Origin of Homochirality - PhD on Expanding Prebiotic Chemistry Through Reactivity in Oil Droplets - Postdoc Molecular motors based DNA-walkers
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Reposted by Radovan Sebesta
Florent Louis, FRSC @florentlouis59.bsky.social · 14/02/2025
📢 PhD position is open in my group starting in october 2025 for 3-years. MSc. 👨‍🎓 interested in environmental chemistry; it is time to apply for exciting science at #PC2A @univlille.bsky.social @cnrs-hautsdefrance.bsky.social @ph15.bsky.social @arizonastateuni.bsky.social deadline: april 25th 2025
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Radovan Sebesta @rsebesta.bsky.social · 27/01/2025
Another product of our passion for catalytic mechanochemistry - Suzuki-type cross-coupling with thianthrenium salts #ChemSusChem, #Mechanochemistry doi.org/10.1002/cssc... @comeniusuni.bsky.social Zuzana Mravikova, Tibor Penaska, Daniela Horniakova
doi.org
Mechanochemical Palladium‐catalyzed Cross‐coupling of Thianthrenium Salts and Arylboronic Acids
Cross-coupling reactions are indispensable for the construction of complex molecular scaffolds. In this work, we developed a sustainable methodology for the cross-coupling reaction of arene thianthre...
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Radovan Sebesta @rsebesta.bsky.social · 10/01/2025
If you are interested in asymmetric organocatalysis and axially chiral compounds, check out our recent review in Beilstein J. Org. Chem. Chem. www.beilstein-journals.org/bjoc/article...
beilstein-journals.org
Recent advances in organocatalytic atroposelective reactions
Beilstein Journal of Organic Chemistry
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Radovan Sebesta @rsebesta.bsky.social · 09/01/2025
If you are interested in how to make carboxamide derivatives of oseltamivir, check out our recent article in EurJOC chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
Utilizing N‐Hydroxylamine‐Based Active Esters for the Synthesis of Oseltamivir Amide Derivatives
Hydroxylamine-derived active esters were synthesized from oseltamivir, which can serve as practical synthetic handles to prepare oseltamivir analogs. Succinimide-based active ester was the most effec...
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Radovan Sebesta @rsebesta.bsky.social · 08/01/2025
I present our newest work on mechanochemical cross-couplings of Reformatsky enolates with aryl halides, which has been published in Advanced Synthesis and Catalysis onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Mechanochemical Pd‐Catalyzed Cross‐Coupling of In‐Situ Generated Reformatsky Zn‐Enolates
Transition-metal-catalyzed α-arylations of carbonyl compounds have shown to be a useful strategy for the late-stage synthesis of α-arylesters. However, the use of strong basic conditions and difficul...
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Radovan Sebesta @rsebesta.bsky.social · 10/12/2024
Our new toy for mechanochemistry! We believe chemical reactions should be shaken, not stirred. :D
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