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Ruhollah (Roohy) Shemirani

@roohy.bsky.social
44 followers 44 following 0 posts

post-doc @SinaiGenomicHealth, USC alum, Population Genetics

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Reposted by Ruhollah (Roohy) Shemirani
Jeff Spence @jeffspence.github.io · 08/08/2025
Cool paper, and -- as expected by how similar the titles are -- dovetails nicely with our work (led by Margaret Antonio, Clemens Weiß, Ziyue Gao, and Susanna Sawyer): elifesciences.org/articles/79714
elifesciences.org
Stable population structure in Europe since the Iron Age, despite high mobility
Reconstructing human mobility patterns using historical period genomes illustrates how the Roman Empire’s military and economic activities catalyzed an era of transient movement against the backdrop o...
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Reposted by Ruhollah (Roohy) Shemirani
Eimear Kenny @eimearekenny.bsky.social · 17/06/2025
📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv! Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses. 🔗 www.medrxiv.org/content/10.1... 1/9
medrxiv.org
SPC: a SPectral Component approach to address recent population structure in genomic analysis
Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), where it can lead to inflated test statistics and spurious associations...
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Reposted by Ruhollah (Roohy) Shemirani
Arslan Zaidi @aazaidi.bsky.social · 25/05/2025
Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver
academic.oup.com
Interpreting SNP heritability in admixed populations
Abstract. SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of h
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Reposted by Ruhollah (Roohy) Shemirani
John Novembre @jnovembre.bsky.social · 04/12/2024
Check it out - PhD student @maggiesteiner.bsky.social's nice thread and link to our new preprint on how sample design, in terms of how geographically narrow vs broad a sample is, impacts the discovery/SFS of deleterious variants.
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Reposted by Ruhollah (Roohy) Shemirani
Eimear Kenny @eimearekenny.bsky.social · 19/11/2024
🚨 New paper alert! 🚨 A new study led by Sinead Cullina (@sineadyc.bsky.social) @ #SinaiGenHealth dives deep into genetic association studies in diverse populations using admixture mapping (AM) & genome-wide association (GWAS). www.medrxiv.org/content/10.1... Here's what you need to know 🧵:
medrxiv.org
Systematic comparison of phenome-wide admixture mapping and genome-wide association in a diverse biobank
Biobank-scale association studies that include Hispanic/Latino(a) (HL) and African American (AA) populations remain underrepresented, limiting the discovery of disease associated genetic factors in th...
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