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Reposted by Roman Doronin

Rainer Friedrich @rainerfriedrichlab.bsky.social · 26/09/2026

Precise structural and functional organization of the olfactory bulb neuropil early in development, revealed by volume EM, dense reconstruction and 2P calcium imaging in zebrafish. Great work by Ruth and others in collaboration with @michalwj.bsky.social www.biorxiv.org/content/10.6...

biorxiv.org

Fine ultrastructural organization of glomerular neuropil in the developing zebrafish olfactory bulb

Across animal phyla, odor information is represented in the first olfactory processing center by combinatorial activation of discrete glomeruli. To examine how this organization of olfactory processin...

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Roman Doronin @romodorro.bsky.social · 25/07/2026

In short, DOI blurs the distinction between the two main domains in the mouse cortex and increases both cortico-cortical and thalamo-cortical functional influence, which could explain this cortical reorganization. Check out the full paper for details! www.biorxiv.org/content/10.6... 10/10

biorxiv.org

The psychedelic DOI decreases the modularity of the cortical network by increasing cortico-cortical and thalamo-cortical functional influence

Psychedelics are powerful modulators of conscious perception, hypothesized to exert their effects by reorganizing large-scale brain functional connectivity. The circuit mechanisms underlying this reor...

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Roman Doronin @romodorro.bsky.social · 25/07/2026

Higher-order thalamocortical influence also increases onto both the AL and the PM domains, consistent with the CSTC theory of psychedelic action. 9/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

The intracortical functional coupling between the domains increases, but unidirectionally: when we opto piu piu the PM domain with a laser, AL responds more strongly under DOI, but not in the reverse direction. 8/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

To understand the circuit mechanisms behind these large-scale changes, we tested two possibilities. One - an increase in the functional coupling between cortical neurons. Second - a change in how strongly thalamic input influences the cortex. 7/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

These changes are also cell-type specific — they occur in L2/3 and L5 IT, but not L5 ET neurons. 6/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

How could this happen? If at baseline the AL domain fluctuates on its own, disjointed from PM, and these fluctuations subside under DOI, it should lead to a decrease in the functional separation between the domains. And this is what we see: activity variance decreases selectively in AL. 5/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

Turns out that the psychedelic DOI blurs the functional distinction between the AL and PM domains, making their activity more similar to each other, and this depends on 5-HT2A receptors. This parallels the between-network reorganization seen in human imaging (e.g. Girn 2026). 4/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

The whole cortex can be partitioned into two main domains that are weakly correlated with each other: the anterolateral (AL) and the posteromedial (PM). How do psychedelics change this organization? 3/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

First, we needed to understand the baseline large-scale organization of the mouse cortex. For this we used widefield imaging, which captures calcium activity across the whole dorsal cortex. This allowed us to measure the similarity of activity across different areas 2/10

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Roman Doronin @romodorro.bsky.social · 25/07/2026

How do psychedelics reorganize cortical communication at the circuit level? In our new paper with @georgkeller.bsky.social we look into how the psychedelic DOI breaks down cortical modularity, and map the underlying cortico-cortical and thalamo-cortical mechanisms in mice – a thread 1/10

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Reposted by Roman Doronin

Georg Keller @georgkeller.bsky.social · 15/04/2026

For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event. A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit. Work led by @therehugolad.bsky.social

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Reposted by Roman Doronin

Katharina Schmack @kathaschmack.bsky.social · 31/03/2026

🥁🎉The Psychosis Collective proudly presents our first preprint 𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞 𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴 starring Le He & Harriet Feldman www.biorxiv.org/content/10.6... We wanted to understand how antipsychotics work. Thread🧵

Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

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Reposted by Roman Doronin

Georg Keller @georgkeller.bsky.social · 31/03/2026

Very excited to share new work by Leonardo Lupori. In mice, a single dose of the antipsychotic clozapine results in changes to behavior and cortical activity patterns that remain detectable a week later. www.biorxiv.org/content/10.6...

biorxiv.org

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