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Leah Roe

@roeleah.bsky.social
75 followers 114 following 1 posts

Chemical biologist. Protein editing. Dog mom and nature enthusiast.

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Reposted by Leah Roe
NSF C-GEM @cgemcci.bsky.social · 20/11/2025
✨ New paper in Science: An archaeal genetic code with all TAG codons as pyrrolysine. www.science.org/doi/10.1126/... A collaboration with @innovativegenomics.bsky.social Congrats to the Banfield lab, @roeleah.bsky.social , @nxhamlish.bsky.social , and Alanna! #NSFfunded
science.org
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
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Reposted by Leah Roe
NSF C-GEM @cgemcci.bsky.social · 21/08/2025
✨New in Nat Chem Biol: Site-selective protein editing by backbone extension acyl rearrangements bit.ly/4oKQ251 Congrats @roeleah.bsky.social, Izzi, Carly, Taylor, Bhavana, @nxhamlish.bsky.social, Arjun, Diondra, Zhongqi, @achemsynbio.bsky.social, Matt, Scott, Alanna, and collaborators! #NSFfunded
nature.com
Site-selective protein editing by backbone extension acyl rearrangements - Nature Chemical Biology
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-pe...
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Reposted by Leah Roe
Nature Chemical Biology @natchembio.nature.com · 21/08/2025
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-, γ-, or δ-peptide backbone www.nature.com/articles/s41...
nature.com
Site-selective protein editing by backbone extension acyl rearrangements - Nature Chemical Biology
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-pe...
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Leah Roe @roeleah.bsky.social · 21/08/2025
I created a protein backbone editing method and named it after my alma mater (x2)! Out now in Nature ChemBio, we show the first examples of a β2-, γ-, and δ-amino acid encoded into full length proteins expressed in cells. www.nature.com/articles/s41...
nature.com
Site-selective protein editing by backbone extension acyl rearrangements - Nature Chemical Biology
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-pe...
042
Reposted by Leah Roe
NSF C-GEM @cgemcci.bsky.social · 04/12/2023
✨ New from C-GEM: High yield, low magnesium flexizyme reactions in a water-ice eutectic phase 💧🧊 Congrats to Josh, Jose, Mace, Evan, Angelin, Isaac, Alanna, Aaron, and Kate! #NSFfunded #synbio www.biorxiv.org/content/10.1...
biorxiv.org
High yield, low magnesium flexizyme reactions in a water-ice eutectic phase
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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