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Rodolpho Souza

@rodolphosouza1.bsky.social
272 followers 185 following 10 posts

Postdoc Arrizabalaga Lab #parasites #mitochondrion #metabolism #cellbiology 🇧🇷🔬🏳️‍🌈 If I post in Portuguese (BR), it might not be about work. lol

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Rodolpho Souza @rodolphosouza1.bsky.social · 29/09/2026
Buffalo from the Lake.
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Agathe Chaigne @agathechaigne.bsky.social · 24/09/2026
I'm super proud of this review written (mostly) by Zoé Ducarne and @myanhtruong.bsky.social about the extraordinary genomic features of the placenta. Such a crazy organ! journals.biologists.com/dev/article/...
journals.biologists.com
The curious case of the placental genome
Summary: The placenta is the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. This Review highlights its high mutational load, structural variants, aneupl...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 31/08/2026
Discovering 25 novel phyla that fill gaps in the eukaryotic tree of life www.biorxiv.org/content/10.64898/20…
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Jiménez-Ruiz Lab @jimenezruizlab.bsky.social · 27/08/2026
The study focuses on PCKMT, AKMT and the Plasmodium enzyme PfSET9. Check it out here: www.nature.com/articles/s41... #Apicomplexa #Methylation #CellMotility #Toxoplasma #Plasmodium
nature.com
Dual apical methyltransferases orchestrate motility initiation in apicomplexan parasites - Nature Communications
This study identifies the Apicomplexa-specific methyltransferase PCKMT and reveals how it works with the previously known AKMT in a two-step pathway that initiates parasite motility and invasion.
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Tobias Warnecke @tobiaswarnecke.bsky.social · 22/08/2026
Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n
biorxiv.org
Chromatin is dispensable for bacterial life
Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...
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Holly Moeller @mixotrophe.bsky.social · 07/08/2026
Freaking finally! A massive compilation of data that sat on various desks for almost a decade is finally out. On the positive side, gave me time to learn expansion microscopy and make Fig 1 www.science.org/doi/10.1126/...
science.org
Emergent metabolic parasitism driven by organelle sequestration
Chloroplast-stealing ciliates evolve, increasing reliance on their prey for all aspects of metabolism, including photosynthesis.
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PLOS Biology @plosbiology.org · 05/08/2026
Graphing and statistically analyzing data is challenging without coding expertise. This Community Page by @avishenoy.bsky.social introduces grafify online, a free, browser app for generating publication-quality graphs and performing statistical tests and comparisons. 🧪 #AcademicSky plos.io/3RpUg6E
Types of graphs and color schemes available in grafify online.
A. Examples of graphs that can be plotted with grafify online. Box and whiskers and violin plots show a line at the median with a box representing the interquartile range (IQR) and whiskers that show 1.5× IQR. Bar graphs and point and error-bar plots show the mean, and the dispersion can be shown as standard deviation (default), standard error of mean, or 95% confidence intervals. Before–after plots show matched data. Numeric XY graphs have numeric variables on both and X- and Y-axes and require a grouping variable that is either categorical (Numeric XY 1) or numeric (Numeric XY 2). B. Categorical (left) and numeric (right) color palettes that are accessible to colorblind individuals
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SheinerLab @sheinerlab.bsky.social · 03/08/2026
We knew Toxoplasma Type I needs fats to survive in culture. Now we show this in Toxoplasma Type II, responsible for most human infections in Europe and North America. Blocking fatty acid elongation reduced growth and persistence in lab culture and in animals. www.biorxiv.org/content/10.6...
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Rodolpho Souza @rodolphosouza1.bsky.social · 23/07/2026
Reviewer #2 is ready to read your paper.
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 22/07/2026
Cryptosporidium sequentially remodels its single rhoptry into the host interface www.biorxiv.org/content/10.64898/20…
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PLOS Biology @plosbiology.org · 20/07/2026
Regulation of gene expression in the #parasite #Leishmania is largely post-transcriptional, but how is it controlled? This study shows that modification of tRNAs by #quenosine influences codon-biased translation and contributes to Leishmania virulence @plosbiology.org 🧪 plos.io/4bwvAjs
Model illustrating the role of queuosine (Q) tRNA modification in the virulence of L. mexicana. Q-tRNA levels increase significantly during the differentiation from the procyclic promastigotes (insect stage) to the axenic amastigotes (mammalian stage), underscoring the importance of Q-tRNA modification for parasite adaptation and infectivity. Loss of Q modification via LmxTGT2 knockout disrupts codon-biased translational control, leading to substantial changes in the proteome. Specifically, downregulated proteins were enriched in NAU codons decoded by Q-tRNA, while upregulated proteins predominantly contained NAC codons. The resulting codon-specific imbalance impairs the parasite’s ability to establish infection and maintain virulence. These findings demonstrate that Q modification functions as a novel post-transcriptional regulatory mechanism that fine-tunes translation during Leishmania life cycle, compensating for the lack of classical transcriptional control and promoting adaptation to the host environment.
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Nature Microbiology @natmicrobiol.nature.com · 30/04/2026
Out Now! Prioritizing prenatal screening to prevent Chagas disease #MicroSky
go.nature.com
Prioritizing prenatal screening to prevent Chagas disease
Nature Microbiology, Published online: 30 April 2026; doi:10.1038/s41564-026-02342-2Prioritizing prenatal screening to prevent Chagas disease
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Rodolpho Souza @rodolphosouza1.bsky.social · 10/04/2026
We have a new preprint out! This time, we discovered that correct mitochondrial positioning in Toxoplasma is important for the metabolism of key cofactors and for sensing conditions that drive parasite egress. www.biorxiv.org/content/10.6...
biorxiv.org
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Groovy Tasia @groovytasia.bsky.social · 08/04/2026
Sorry I was late to the meeting. The dog had to spin around 80 times to make sure he was pooping at the right angle.
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Journal of Cell Science @jcellsci.bsky.social · 07/04/2026
In their Review, Prasanna Katti, Antentor Hinton, Jr and colleagues discuss how imaging techniques have advanced our understanding of mitochondrial biology. journals.biologists.com/jcs/article/...
TEM and vEM reveal mitochondrial ultrastructure and organelle interactions.
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Eva Frickel @frickellab.bsky.social · 04/03/2026
Hot off the biorxiv press! 🔥 Samuel Lara-Reyna finds GBP5 enhances macrophage glycolysis via glucose uptake, GTPase activity dependent and as being cis-Golgi localised. Bonus finding, GBP5 is important for full M1 macrophage functionality. www.biorxiv.org/content/10.6...
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LabEx ParaFrap @parafrap.bsky.social · 24/02/2026
📆 Join the 2026 Biology of Host–Parasite Interactions GRC (June 7–12, Newport, RI) 🌟 Cutting-edge science, open slots for talks & posters 🧑‍🔬 GRS for grad students & postdocs the weekend before 📩 Apply by May 18, 2026 (early submission encouraged) 👉 Details & application: www.grc.org/biology-of-h...
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Rafael Polidoro @rafaelpolidoro.bsky.social · 25/01/2026
As the review process goes, take a sneak peak of our exciting manuscript. I'll make a proper thread when it's fully out!
biorxiv.org
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Rodolpho Souza @rodolphosouza1.bsky.social · 20/01/2026
Are you sure you’re working???
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Ira Blader @bladerlab.bsky.social · 14/01/2026
Interested in how infections cause seizures? Then, read on! We discovered that Toxoplasma selectively eliminates inhibitory synapses in brain. You will study how these synapses are removed. Please send brief review of research interests and goals, CV, and names of 3 refs to: iblader@vt.edu.
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Journal of Cell Science @jcellsci.bsky.social · 13/01/2026
Isadonna Tengganu and Ke Hu develop transfection and ExM protocols for Chromera velia, enabling direct comparisons with its parasitic apicomplexan relative, Toxoplasma gondi. journals.biologists.com/jcs/article/...
Comparison of the cytoskeletal architectures of Toxoplasma and Chromera flagellates using ExM.
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Stirling Churchman @stirlingchurchman.bsky.social · 03/12/2025
Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.
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Toxo18 Brasil @toxo18.bsky.social · 23/10/2025
Save the date‼️ 💡 More information coming soon about registration and the scientific program. #TOXO18 #Toxoplasma #Immunoparasitology #Buzios2026 #ScienceByTheSea
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Arnau Sebé-Pedrós @arnausebe.bsky.social · 24/09/2025
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...
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Oded Rechavi @odedrechavi.bsky.social · 19/09/2025
Geographic distribution of human toxoplasmosis
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Rodolpho Souza @rodolphosouza1.bsky.social · 15/09/2025
Favorite time of the year!
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PLOS Biology @plosbiology.org · 22/07/2025
#Mitochondrial proteins are synthesized with presequences that target them to the #mitochondrion, but why are some more efficient than others? This study identifies presequences which recruit Hsp90 co-chaperones & TOMM34 to confer prioritized import efficiency @plosbiology.org 🧪 plos.io/4m6spBN
Model of the enhanced targeting competence of group A presequences: The specific recruitment of targeting factors such as TOMM34 and Cns1 can increase the import efficiency in a Tom70-mediated manner.
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PLOS Biology @plosbiology.org · 10/02/2025
Aye-ayes are clearly unusual, but @glom.bsky.social @3rdreviewer.bsky.social &co show that they also have an unusual pattern of #MutationBias; older females transmit more mutations than males. This is a first for mammals, raising questions about other #lemurs 🧪 @plosbiology.org plos.io/40SR4kj
Top: A picture of the aye-aye named Elphaba. Image credit: David Haring, Duke Lemur Center. Bottom: Pedigree structure of the aye-ayes used in this study. The 18 individuals sequenced in this study are shown: males as squares and females as circles. Two individuals (IDs 100937 and 100935) appear multiple places in the pedigree, each time connected by a dashed line. Elphaba is at the bottom right.
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Rodolpho Souza @rodolphosouza1.bsky.social · 06/02/2025
It is impossible to work from home.
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Megan Sloan @sloanmegan.bsky.social · 05/02/2025
Excited to be able to share our new paper 'Iron Mediated Post-Transcriptional Regulation in Toxoplasma gondii'! Thanks to all involved including the awesome @clarehardinglab.bsky.social and @danaaghabi.bsky.social! journals.plos.org/plospathogen.... Read on for quick-read digest of our new work...
journals.plos.org
Iron-mediated post-transcriptional regulation in Toxoplasma gondii
Author summary Although iron is essential for most cells, excess can be toxic, so uptake and storage must be carefully controlled. The ability to respond to iron is particularly important for parasite...
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Rodolpho Souza @rodolphosouza1.bsky.social · 18/11/2024
I haven’t posted anything yet, but my first post shows my new city and my best paw. He’s not a Colts fan anymore.
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