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Robert Blelloch

@robertblelloch.bsky.social
567 followers 7 following 9 posts

Peter R. Carroll Distinguished Professor and Vice Chair of Research of Urology, UCSF

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Robert Blelloch @robertblelloch.bsky.social · 26/08/2026
5. Given that we are dressing a universal cell product with full repertoire of MHC-peptides from the patient’s tumor, the resulting cells are both recognized as self while presenting the full complexity of potentially immune activating tumor epitopes.
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Robert Blelloch @robertblelloch.bsky.social · 26/08/2026
4. The approach produces a near homogeneous migratory DC population, the specific population of dendritic cells that travel to the lymph nodes to induce naïve T cells into effector cells that can then attack the tumor.
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Robert Blelloch @robertblelloch.bsky.social · 26/08/2026
3. Given the starting population is always the same, the quantity and quality of cells produced is reproducible, unlike autologous approaches which vary greatly based on quality and quantity of the cells collected from the patient.
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Robert Blelloch @robertblelloch.bsky.social · 26/08/2026
2. Given that we are starting with the iPSCs, there are essentially no constraints on the types and number of genetic optimizations that can be made.
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Robert Blelloch @robertblelloch.bsky.social · 26/08/2026
1. Reproducible production of an unlimited number of off-the-shelf genetically optimized CCR7+ migratory dendritic cells which are then personalized to each patient’s tumor.
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Robert Blelloch @robertblelloch.bsky.social · 26/08/2026
@ucsfstemcell.bsky.social Why we believe this paper is so important: www.cell.com/cell-stem-ce...
cell.com
Engineered human iPSC-derived dendritic cells dressed with tumor MHC complexes as a cancer vaccine
Blelloch and colleagues create genetically engineered universal human iPSCs, differentiate them into CCR7+ migratory dendritic cells, and dress them with tumor-derived MHC class I-antigen complexes to...
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Reposted by Robert Blelloch
UCSF Broad Stem Cell Center @ucsfstemcell.bsky.social · 25/08/2026
@robertblelloch.bsky.social + team engineered iPSC-derived dendritic cells coated w/ patient tumor membranes to present multiple cancer antigens to T cells. The approach induced tumor-specific T cell responses in patient samples and slowed tumor growth in humanized mice. www.cell.com/cell-stem-ce...
cell.com
Engineered human iPSC-derived dendritic cells dressed with tumor MHC complexes as a cancer vaccine
Blelloch and colleagues create genetically engineered universal human iPSCs, differentiate them into CCR7+ migratory dendritic cells, and dress them with tumor-derived MHC class I-antigen complexes to...
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Reposted by Robert Blelloch
Deniz Gökbuget @denizgoekbuget.bsky.social · 25/08/2026
Excited to share this new paper: Universal iPSC-derived dendritic cells "dressed" with tumor MHC complexes as an off-the-shelf cancer vaccine. Glad I could help on the computational side. Congrats to @huaigengxu.bsky.social, Chisato, @robertblelloch.bsky.social for getting this over the finish line!
cell.com
Engineered human iPSC-derived dendritic cells dressed with tumor MHC complexes as a cancer vaccine
Blelloch and colleagues create genetically engineered universal human iPSCs, differentiate them into CCR7+ migratory dendritic cells, and dress them with tumor-derived MHC class I-antigen complexes to...
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Robert Blelloch @robertblelloch.bsky.social · 11/06/2025
great start to ISSCR annual meeting. great session on immune engineering this morning @isscr.org #isscr2025
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Reposted by Robert Blelloch
HuaigengXu @huaigengxu.bsky.social · 11/06/2025
Dress to kill. Come to see how I created a novel cancer vaccine by transferring MHC-peptide complexes from tumor cells to universal iPSC-derived Dendritic cells. #ISSCR2025 AI and Cancer Evolution Session, Friday 8:30am, Convention Hall B, level 1 @ucsfcancer.bsky.social @ucsfstemcell.bsky.social
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Robert Blelloch @robertblelloch.bsky.social · 11/06/2025
so excited to see Huaigeng share this story outside UCSF for the first time.
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Robert Blelloch @robertblelloch.bsky.social · 06/02/2025
Congratulations on an amazing paper. A must read.
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Reposted by Robert Blelloch
Deniz Gökbuget @denizgoekbuget.bsky.social · 04/02/2025
🚨 New Paper Alert! 🚨 Our latest study on KMT2C/KMT2D (mutated in 20% of cancers) reveals a new function for H3K4me1 in regulating DNA replication timing (RT) and origin activity during cell state transitions. Check it out: www.cell.com/cell-reports.... More info ⬇️
cell.com
KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition
Gökbuget et al. use machine learning to quantify chromatin state changes that predict DNA replication timing changes during cell differentiation. By following up on top predictors through functional v...
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Reposted by Robert Blelloch
Blelloch Lab UCSF @rblellochlab.bsky.social · 14/11/2024
Huaigeng is presenting his exciting work on developing cancer vaccines today at the UCSF Prostate Program retreat.
Huaigeng Xu at the podium ready to give his presentation.Huaigeng Xu at the retreat
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