RNA sensors are challenging to design but hold potential for impactful diagnostics. Now, a multi-faceted approach leverages crowdsourcing and computational automation to enable the design of compact R...

Protein binder design has been transformed by hallucination-based methods that optimize structure prediction confidence metrics, such as the interface predicted TM-score (ipTM), via backpropagation. H...

A deep learning platform for structure-guided, generative design of RNA sequences is developed and used to discover fluorescent RNA aptamers.

The 3D structure of RNA is crucial for unraveling its functions. Here, the authors developed NuFold, an end-to-end deep learning-based approach that predicts all-atom RNA 3D structures from sequences....

A protein language model enables structure prediction and analysis of more than 600 million metagenomic proteins.

Northwestern researchers received notices from the Department of Defense to stop their work immediately.

Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA exosome. This study provides fundamental insight into how the RNA exosome specifically recognizes misprocessed RNAs.

Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA ex...

Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA ex...