Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...

This cross-journal Collection welcomes manuscripts covering a broad spectrum of research related to phages, including fundamental studies on phage biology and ...

Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in understanding the mechanism behind ...

Antimicrobial resistance can decline due to compensatory mutations or genetic reversions to wild-type alleles. Here, the authors analyse the decline of ciprofloxacin resistance in nfxB-defective Pseud...

Streptococcus pneumoniae, the causative agent of pneumococcal disease, has become increasingly resistant to fluoroquinolones. Through CRISPRi-seq, the authors identify the role of the LiaFSR operon in...