Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues...

The psychostimulant methylphenidate (MPH) is the first-line pharmacological treatment for attentiondeficit/hyperactivity disorder (ADHD), but has numerous ad...

Hemicrania continua is characterised by a daily and continuous head pain on one side of the head with superimposed exacerbations of a more severe headache

<p>In previous research, we demonstrated that long-term consumption of thermally oxidized oil leads to neuroinflammation and anxiety in mice. Therefore, in this study, we employed polar lipid componen...

Multidrug-resistant bacterial pathogens pose an increasing threat to human health. Certain bacteria, such as <i>Staphylococcus aureus</i>, are able to survive within professional phagocytes to escape the bactericidal effects of antibiotics and evade killing by immune cells, potentially leading to ch …

Two non-invasive tests can now be used to speed up the diagnosis of endometriosis in primary care while further evidence of their accuracy is collected, following a recommendation from the National In...

Mitochondria serve an essential metabolic and energetic role in cellular activity, and their dysfunction has been implicated in a wide range of disorders, including cardiovascular conditions, neurodeg...

The presence of certain bacteria in the gut microbiota, and fluctuations in a person's metabolism, can be seen in people who go on to develop type 2 diabetes years later. This has been shown in a larg...

Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes to insulin resistance, and treatment with tauro...

Researchers at Ume&aring; University have conducted a unique three-dimensional mapping of an entire human pancreas. The study shows that insulin-producing cells can remain long after the onset of type 1 diabetes &ndash; a finding that suggests the disea...

Karius Spectrum is an infectious disease blood test that uses next-generation sequencing to detect over 1,000 pathogens with speed and accuracy.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a complex strategy for the transcription of viral subgenomic mRNAs (sgmRNAs), which are targets for nucleic acid diagnostics. Each of t...

Background Neurological Long COVID (n-LC) includes persistent cognitive and autonomic symptoms after SARS-CoV-2 infection. Prior studies of post-COVID conditions have described diverse humoral autorea...

Health officials in British Columbia say invasive mosquitoes and a virus that can cause brain swelling in humans have been detected in the Sea-to-Sky region north of Vancouver, after an investigation triggered by a cluster of childhood encephalitis cases.

Borrelia burgdorferi is a pathogenic bacterium and the causative agent of Lyme disease. It is exposed to reactive oxygen species (ROS) in both the vertebrate and tick hosts. While some mechanisms by w...

Results of this case-control study reveal that persistent high-level EBNA-1 peptide antibody titers may serve as a reliable biomarker for differentiating MS from MOGAD, and NMOSD.

Lyme Borrelia detection at Galaxy Dx improves diagnosis with trusted, science-backed testing solutions.

Thiamine deficiency is a condition that is known to cause damage to the nervous and cardiovascular systems because it interferes with cellular metabol…

A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-...

SARS-CoV-2 infection is associated with respiratory complications, especially during the acute phase. We report an unusual case of an adolescent boy who presented with cough, dyspnea and unilaterally ...

I’ve taken agency in the treatment of my bone cancer (osteosarcoma in the T5 vertebrae of the upper spine). After I’ve ran out of standard of care treatment options and there were no trials available…

Smokers are less likely to develop some inflammatory and allergic diseases. In Brown-Norway rats, nicotine inhibits several parameters of allergic asthma including the production of Th2 cytokines and the cysteinyl leukotriene LTC4. Cysteinyl ...

A duo of drugs that boosts our glymphatic system, which clears waste from our brain, also improves the removal of proteins associated with the onset of Alzheimer's disease

A newly engineered molecule acts like a “rechargeable” solar heat battery, storing sunlight and releasing it on demand.

Preliminary studies demonstrated beneficial effects of dietary creatine across different post-viral fatigue syndromes. Creatine is often co-administer …

CMV infection may occur anywhere in the gastrointestinal tract. Among the small intestine, ileum is the most common site of CMV disease and infection of jejunum is a rare one in patients with CMV gastroenteritis. Although rare, the reason why the ...

Post-COVID condition (PCCo) affects 5% to 10% of individuals following SARS-CoV-2 infection, with cognitive disturbances being a major feature. Centra…