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Rene Sugar

@renesugar.bsky.social
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Rene Sugar @renesugar.bsky.social · 09/10/2026
Anti-GMCSF Autoantibodies #MECFS #LongCovid www.nationaljewish.org/for-professi... "In addition, anti-GMCSF autoantibodies have found to be associated with treatment refractory, chronic bacterial and fungal infections (e.g.; Cryptococcus and Nocardia spp.)."
nationaljewish.org
Anti-GMCSF Autoantibodies
National Jewish Health Advanced Diagnostic Laboratories now offers testing for anti-GMCSF autoantibodies.
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Rene Sugar @renesugar.bsky.social · 02/10/2026
www.science.org/doi/10.1126/... "SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl–coenzyme A (acetyl-CoA) production."
science.org
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues...
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Rene Sugar @renesugar.bsky.social · 02/10/2026
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling #MECFS #LongCovid www.science.org/doi/10.1126/...
science.org
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues...
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Rene Sugar @renesugar.bsky.social · 30/09/2026
Pioglitazone Ameliorates Mitochondrial Oxidative Stress and Inflammation via AMPK-Dependent Inhibition of Mitochondrial Fission in Leigh Syndrome #MECFS #LongCovid pubmed.ncbi.nlm.nih.gov/40767000/
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Rene Sugar @renesugar.bsky.social · 28/09/2026
Pioglitazone enhances brain mitochondrial biogenesis and phase II detoxification capacity in neonatal rats with 6-OHDA-induced unilateral striatal lesions #MECFS #LongCovid www.frontiersin.org/journals/neu...
frontiersin.org
Frontiers | Pioglitazone enhances brain mitochondrial biogenesis and phase II detoxification capacity in neonatal rats with 6-OHDA-induced unilateral striatal lesions
The psychostimulant methylphenidate (MPH) is the first-line pharmacological treatment for attentiondeficit/hyperactivity disorder (ADHD), but has numerous ad...
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Rene Sugar @renesugar.bsky.social · 25/09/2026
lambruneurology.com/hemicrania-c... " Hemicrania continua is exquisitely sensitive to indometacin, a potent painkiller that at the right dose should control the headache completely. Long-term preventive treatments other than indometacin may be required."
lambruneurology.com
Hemicrania continua - Giorgio Lambru - Headache Neurologist
Hemicrania continua is characterised by a daily and continuous head pain on one side of the head with superimposed exacerbations of a more severe headache
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Rene Sugar @renesugar.bsky.social · 25/09/2026
lambruneurology.com/hemicrania-c... "which are often associated with typical facial symptoms namely eye watering, eye redness, runny nose or stuffy nose. Because of the daily head pain, sometimes this condition is misdiagnosed with migraine, sinus headache or a neck problem."
lambruneurology.com
Hemicrania continua - Giorgio Lambru - Headache Neurologist
Hemicrania continua is characterised by a daily and continuous head pain on one side of the head with superimposed exacerbations of a more severe headache
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Rene Sugar @renesugar.bsky.social · 25/09/2026
lambruneurology.com/hemicrania-c... "However, unlike cluster headache or paroxysmal hemicrania, hemicrania continua is characterised by a daily and continuous head pain on one side of the head with superimposed exacerbations of a more severe headache"
lambruneurology.com
Hemicrania continua - Giorgio Lambru - Headache Neurologist
Hemicrania continua is characterised by a daily and continuous head pain on one side of the head with superimposed exacerbations of a more severe headache
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Rene Sugar @renesugar.bsky.social · 25/09/2026
lambruneurology.com/hemicrania-c... "Hemicrania continua is a trigemino-autonomic cephalalgia."
lambruneurology.com
Hemicrania continua - Giorgio Lambru - Headache Neurologist
Hemicrania continua is characterised by a daily and continuous head pain on one side of the head with superimposed exacerbations of a more severe headache
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Rene Sugar @renesugar.bsky.social · 25/09/2026
Hemicrania Continua #MECFS #LongCovid lambruneurology.com/hemicrania-c...
lambruneurology.com
Hemicrania continua - Giorgio Lambru - Headache Neurologist
Hemicrania continua is characterised by a daily and continuous head pain on one side of the head with superimposed exacerbations of a more severe headache
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Rene Sugar @renesugar.bsky.social · 22/09/2026
Linoleic acid alleviates mood disorders in mice by modulating microglia differentiation and arachidonic acid metabolism www.sciopen.com/article/10.2...
sciopen.com
Linoleic acid alleviates mood disorders in mice by modulating microglia differentiation and arachidonic acid metabolism
<p>In previous research, we demonstrated that long-term consumption of thermally oxidized oil leads to neuroinflammation and anxiety in mice. Therefore, in this study, we employed polar lipid componen...
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Rene Sugar @renesugar.bsky.social · 15/09/2026
Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus #MECFS #LongCovid pubmed.ncbi.nlm.nih.gov/36382278/
pubmed.ncbi.nlm.nih.gov
Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus - PubMed
Multidrug-resistant bacterial pathogens pose an increasing threat to human health. Certain bacteria, such as <i>Staphylococcus aureus</i>, are able to survive within professional phagocytes to escape the bactericidal effects of antibiotics and evade killing by immune cells, potentially leading to ch …
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Rene Sugar @renesugar.bsky.social · 22/08/2026
The HIV Integrase Inhibitor Raltegravir Inhibits Felid Alphaherpesvirus 1 Replication by Targeting both DNA Replication and Late Gene Expression pmc.ncbi.nlm.nih.gov/articles/PMC...
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Rene Sugar @renesugar.bsky.social · 07/08/2026
Endometriosis: “Game changing” new tests may speed up diagnosis in primary care www.bmj.com/content/394/... Rapid endometriosis tests to be made available on NHS in England and Wales www.theguardian.com/society/2026...
bmj.com
Endometriosis: “Game changing” new tests may speed up diagnosis in primary care
Two non-invasive tests can now be used to speed up the diagnosis of endometriosis in primary care while further evidence of their accuracy is collected, following a recommendation from the National In...
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Rene Sugar @renesugar.bsky.social · 31/07/2026
Karius Spectrum, Plasma www.mayocliniclabs.com/test-catalog...
mayocliniclabs.com
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Rene Sugar @renesugar.bsky.social · 26/07/2026
The Mitochondrial-Targeted Compound #SS31 ( #elamipretide) Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin journals.lww.com/jasn/abstrac...
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Rene Sugar @renesugar.bsky.social · 26/07/2026
Clinical Trial in Patients With Barth Syndrome- 4TAZPower (4TAZPower) #FORZINITY #Elamipretide #SS31 clinicaltrials.gov/study/NCT075...
clinicaltrials.gov
ClinicalTrials.gov
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Rene Sugar @renesugar.bsky.social · 26/07/2026
Study of Healthy Aging and Physical Function With Elamipretide (SHAPE) #FORZINITY #SS31 clinicaltrials.gov/study/NCT072...
clinicaltrials.gov
ClinicalTrials.gov
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Rene Sugar @renesugar.bsky.social · 26/07/2026
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential #FORZINITY #SS31 pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
Mitochondria serve an essential metabolic and energetic role in cellular activity, and their dysfunction has been implicated in a wide range of disorders, including cardiovascular conditions, neurodeg...
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Rene Sugar @renesugar.bsky.social · 09/07/2026
Gut microbiome composition and functional potential associate with incident type 2 diabetes in 4,685 adults from a Swedish prospective cohort www.cell.com/cell-reports...
cell.com
Gut microbiome composition and functional potential associate with incident type 2 diabetes in 4,685 adults from a Swedish prospective cohort
Toubon et al. show that the gut microbiome measured years before diagnosis predicts future type 2 diabetes risk. Using a large prospective Swedish cohort of 4,685 adults, they identify specific microb...
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Rene Sugar @renesugar.bsky.social · 09/07/2026
Gut microbiota can predict risk of type 2 diabetes years before it develops #MECFS #LongCovid medicalxpress.com/news/2026-07... Akkermansia muciniphila "feeds on the fiber we get from our diet. But when our fiber intake is too low, it instead starts to break down the gut's protective mucus layer."
medicalxpress.com
Gut microbiota can predict risk of type 2 diabetes years before it develops
The presence of certain bacteria in the gut microbiota, and fluctuations in a person's metabolism, can be seen in people who go on to develop type 2 diabetes years later. This has been shown in a larg...
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Rene Sugar @renesugar.bsky.social · 03/07/2026
Mitochondrial Electron Transport Chain Complex I Impairment #MECFS #LongCovid
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Rene Sugar @renesugar.bsky.social · 30/06/2026
The Ambitious Dragon Beijing’s Calculus for Invading Taiwan by 2030 www.airuniversity.af.edu/JIPA/Display...
airuniversity.af.edu
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Rene Sugar @renesugar.bsky.social · 30/06/2026
The Ambitious Dragon Beijing’s Calculus for Invading Taiwan by 2030 (archived copy) web.archive.org/web/20250122...
web.archive.org
Wayback Machine
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Rene Sugar @renesugar.bsky.social · 27/06/2026
Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women #TUDCA #MECFS #LongCovid pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women
Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes to insulin resistance, and treatment with tauro...
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Rene Sugar @renesugar.bsky.social · 26/06/2026
You Now May Have Better Access to Metagenomics for Infectious Disease A Conversation with Alec Ford of Karius www.idse.net/Multimedia/A...
idse.net
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Reposted by Rene Sugar
EurekAlert! @eurekalert.bsky.social · 28/05/2026
Researchers @umeauniversitet.bsky.social have conducted a unique three-dimensional mapping of an entire human pancreas. The study suggests that the progression of type 1 diabetes is more complex than previously assumed. Learn more: www.eurekalert.org/news-releases/11…
eurekalert.org
Whole organ 3D imaging reveals remaining insulin producing cells in type 1 diabetes
Researchers at Ume&aring; University have conducted a unique three-dimensional mapping of an entire human pancreas. The study shows that insulin-producing cells can remain long after the onset of type 1 diabetes &ndash; a finding that suggests the disea...
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Rene Sugar @renesugar.bsky.social · 22/06/2026
Lyme Borrelia Nanotrap® Urine Antigen Test #MECFS #LongCovid bsky.app/profile/rene...
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Rene Sugar @renesugar.bsky.social · 22/06/2026
MI Profile Comprehensive Molecular Profiling (cancer) www.carislifesciences.com/physicians/ "MI Profile® comprehensive testing delivers whole exome sequencing (WES – DNA) and whole transcriptome sequencing (WTS – RNA) for 23,000+ genes, as well as protein analysis and AI-predictive algorithms"
carislifesciences.com
Physicians | Caris Life Sciences
Discover Caris Life Sciences' advanced molecular profiling services, including whole exome and transcriptome sequencing, to guide personalized cancer treatment decisions.
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Rene Sugar @renesugar.bsky.social · 22/06/2026
Micronbrane PaRTI-Seq™ workflow micronbrane.com/mngs/ "mNGS testing — metagenomic next-generation sequencing — identifies pathogens directly from a clinical specimen by sequencing all nucleic acids in the sample."
micronbrane.com
mNGS Testing Workflow: Cost, Turnaround, and Results
Decide when mNGS testing fits your lab workflow. Compare turnaround, host depletion, sequencing depth, cost per sample, and pathogen detection evidence.
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Rene Sugar @renesugar.bsky.social · 22/06/2026
Karius Spectrum #MECFS #LongCovid kariusdx.com/our-solution... "is a blood test leveraging plasma metagenomic sequencing of microbial cell-free DNA to detect over 1,000 fungi, bacteria, parasites, and DNA viruses associated with deep-seated and difficult-to-diagnose systemic infections."
kariusdx.com
Karius Spectrum - Advanced Infectious Disease Blood Test | Karius
Karius Spectrum is an infectious disease blood test that uses next-generation sequencing to detect over 1,000 pathogens with speed and accuracy.
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Rene Sugar @renesugar.bsky.social · 21/06/2026
Dengue virus infection reprograms baseline innate immune gene expression www.sciencedirect.com/science/arti...
sciencedirect.com
Dengue virus infection reprograms baseline innate immune gene expression
All three dengue vaccines that have completed phase 3 clinical trials have shown greater efficacy in dengue-seropositive compared to dengue-seronegati…
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Rene Sugar @renesugar.bsky.social · 21/06/2026
Comparing DNA Methylation Landscapes in Peripheral Blood from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Patients #MECFS #LongCovid www.mdpi.com/1422-0067/26...
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Rene Sugar @renesugar.bsky.social · 15/06/2026
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Rene Sugar @renesugar.bsky.social · 15/06/2026
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Rene Sugar @renesugar.bsky.social · 15/06/2026
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Rene Sugar @renesugar.bsky.social · 15/06/2026
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Rene Sugar @renesugar.bsky.social · 15/06/2026
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Rene Sugar @renesugar.bsky.social · 15/06/2026
Metabolic trap doors in Myalgic Encephalomyelitis #MECFS
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Rene Sugar @renesugar.bsky.social · 08/06/2026
Coronavirus Leader-TRS identification tool (Dong et al 2022) github.com/Hiscox-lab/L...
github.com
GitHub - Hiscox-lab/LeTRS: Coronavirus Leader-TRS identification tool (Dong et al 2022)
Coronavirus Leader-TRS identification tool (Dong et al 2022) - Hiscox-lab/LeTRS
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Rene Sugar @renesugar.bsky.social · 08/06/2026
Supporting data for"Identification and quantification of #SARSCoV2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of #COVID19 and dysregulation at later time points that can also be identified in humans" gigadb.org/dataset/102209
gigadb.org
GigaDB
GigaDB.
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Rene Sugar @renesugar.bsky.social · 08/06/2026
Analysis of #SARSCoV2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a complex strategy for the transcription of viral subgenomic mRNAs (sgmRNAs), which are targets for nucleic acid diagnostics. Each of t...
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Rene Sugar @renesugar.bsky.social · 07/06/2026
Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome #MECFS www.research.ed.ac.uk/en/publicati... www.pure.ed.ac.uk/ws/portalfil...
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Rene Sugar @renesugar.bsky.social · 07/06/2026
🧵 The "Software vs. Hardware" Myth in FND: What the Scans Actually Show #MECFS #LongCovid bsky.app/profile/rene...
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Rene Sugar @renesugar.bsky.social · 07/06/2026
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Rene Sugar @renesugar.bsky.social · 07/06/2026
🧵 The "Software vs. Hardware" Myth in FND: What the Scans Actually Show #MECFS #LongCovid
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Rene Sugar @renesugar.bsky.social · 05/06/2026
"changing beliefs cannot manufacture cobalamin or stop the demyelination of the spinal cord caused by a vitamin B12 deficiency"
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Rene Sugar @renesugar.bsky.social · 05/06/2026
www.ilads.org/patient-care... "ILADS recommends against the use of a single 200 mg dose of doxycycline for the prevention of Lyme disease. Not only is it unlikely to be highly efficacious, in the human trial failed therapy led to a seronegative disease state."
ilads.org
ILADS Treatment Guidelines - ILADS
Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease Daniel J. Cameron, MD MPH; Lorraine B. J...
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Rene Sugar @renesugar.bsky.social · 05/06/2026
Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease www.ilads.org/patient-care...
ilads.org
ILADS Treatment Guidelines - ILADS
Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease Daniel J. Cameron, MD MPH; Lorraine B. J...
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Rene Sugar @renesugar.bsky.social · 05/06/2026
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