iiinova — where your digital self keeps evolving

Reposted by Mark Rebeiz

EvoDevo PanAm @evodevopanam.bsky.social · 29/08/2026

🌟PASEDB community 🌟 We are inviting nominations for awards to recognize exceptional contributions and achievements to the PASEDB and broader EvoDevo community 📆Deadline: October 15, 2026 ✉️To make a nomination, please email Igor Schneider - igors@lsu.edu @ischneider.bsky.social

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Reposted by Mark Rebeiz

Genetics Society of America @genetics-gsa.bsky.social · 24/12/2025

@rebeizlab.bsky.social presents a detailed 3D atlas of transcription factors expressed in developing genital structures in #Drosophila. This new resource in #GENETICS suggests that the same transcription factors may control development in female and male genitalia. buff.ly/ICLiC2F

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Mark Rebeiz @rebeizlab.bsky.social · 17/06/2025

Really excited for PASEDB2025 in July!

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Reposted by Mark Rebeiz

EvoDevo PanAm @evodevopanam.bsky.social · 06/06/2025

🐟 I’ve been herring all about it! Fish satellite symposia speaker talks at #PASEDB Invited speaker: @fishevodevogeno.bsky.social Organizers: @nakamuralab.bsky.social @patyschneider22.bsky.social & Joaquín Letelier Register: evodevo.wildapricot.org/event-6007396

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Reposted by Mark Rebeiz

EvoDevo PanAm @evodevopanam.bsky.social · 21/05/2025

🌟Remember to register #PASEDB 2025 Biennial Meeting (July 22-25)! We have an incredible line up of activities and speakers, including 4 satellite symposia (July 22): Spiralia🐌, Arthropods🦋, Fishes🐟 and Non-bilaterian 🪸 Register and submit today! evodevo.wildapricot.org/event-6007396

evodevo.wildapricot.org

The Pan American Society for Evolutionary Developmental Biology - 2025 Biennial Meeting of the Pan American Society for Evolutionary Developmental Biology

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Reposted by Mark Rebeiz

EvoDevo PanAm @evodevopanam.bsky.social · 09/05/2025

🌟We have great satellite meetings!🥳😎 - Spiralia 🐌🪱 - Arthropods 🦋🦗🪰🪳 - Fishes🐠🐟🐡 - Non-bilaterian 🪼🪸 Remember to register here: evodevo.wildapricot.org/event-6007396 #evodevo #pasedb #science

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Mark Rebeiz @rebeizlab.bsky.social · 30/10/2024

Thanks so much Amber! Hope you are having an awesome time in your postdoc!

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

Thank you to the O'Connor-Giles lab for updating the incredible CRISPR Optimal Target Finder to include D. eugracilis. @bdsc.bsky.social for lines, and @flybase.bsky.social for being our favorite database

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

We want to thank our amazing collaborators Julia Zeitlinger and Tatiana Gaitan. We cannot wait to share more as we continue to dive deeper into how the trichome genetic network has specialized!

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

Our results demonstrate the power of genetic network co-option to redeploy a genetic network into a new tissue context. Yet, novelties are more than mere iterations of repeated structures. We reflect on how they derive unique features by elaborating their network architecture.

Schematic representation of the origin and specialization of the D. eugracilis aedaegal sheath trichomes and its genetic network

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

Misexpression of the active form of shavenbaby in the naïve aedeagal sheath of D. melanogaster was sufficient to induce small trichomes. This is one of the first times that genetic network co-option has been recapitulated through experimental manipulations.

induction of ectopic trichomes in D. melanogaster by mis-expressing shavenbaby.

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

Disruption of shavenbaby via mosaic CRISPR caused the truncation of trichome height, showing the important role of shavenbaby, but also indicating that there are likely other redundant transcription factors as well

adult aedaegal sheaths of D. eugracilis control and shavenbaby CRISPR treatments which reduced height of the largest trichomes.

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

Additionally, we find that the trichome genetic network was partially co-opted into the aedeagal sheath as 14 (purple) out of 23 direct targets of shavenbaby we tested have gained expression in the D. eugracilis aedeagal sheath

shavenbaby GRN showing multiple downstream functions (ECM, actin and "other".

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

The novel unicellular outgrowths of D. eugracilis have evolved expression of the key trichome transcription factor shavenbaby, named for its mutant phenotype, in which trichome morphology is disrupted

expression of shavenbaby protein (top) and mRNA (bottom) in D. melanogaster (no expression in the sheath) and D. eugracilis (expression in the sheath - outlined)

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

We found that each of these outgrowths develop as an actin-rich (magenta) extension of a single cell (apical cell junctions grey), similar to trichomes, hair-like structures that cover the larvae and much of the adult cuticle

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

We developed the rapidly evolving drosophilid terminalia as a model to explore the genetic basis of novelty. D. eugracilis has over 150 differently sized outgrowths on its aedeagal sheath which appear to be absent from other species of Drosophila, including D. melanogaster.

The adult aedeagal sheaths of D. pseudoobscura, D. ananassae, D. melanogaster, and D. eugracilis (which is the only species with a variety of differently sized outgrowths).

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Mark Rebeiz @rebeizlab.bsky.social · 28/10/2024

Our new @CurrentBiology paper provides a rare glimpse into a morphological novelty in Drosophila eugracilis In it, @gavinrrice and colleagues, infer and reproduce the likely initial steps of a novelty's formation www.sciencedirect.com/science/arti...

3D micrograph of the developing D. eugracilis terminalia

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