Engineered SOX17 factors, including a miniaturized variant, replace SOX2 to drive efficient direct reprogramming to induced human expanded potential stem cells under feeder-based and feeder-free cultu...

New cancer therapies are needed that do not harm healthy tissue. An engineered DNA sequence shows promise as one of the tools in a method to target brain tumour cells. New cancer therapies are needed that do not harm healthy tissue. An engineered DNA sequence shows promise as one of the tools in a method to target brain tumour cells.

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Startup Colossal Biosciences has edited the DNA of a gray wolf to produce what it says is a de-extincted animal. Does that make it a true dire wolf?

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In this article, Jauch and colleagues show that glutamate 57 is essential to preserve the DNA binding mechanism of SOX17. Mutations at this site into diverse amino acids turn SOX17 into a powerful alt...

In a groundbreaking experiment, researchers have brought a mouse to life with the help of a single-celled organism that existed long before any multicellular animals walked the earth.

The team used these newly generated stem cells to help form a living, breathing mouse from a developing embryo.