New cancer therapies are needed that do not harm healthy tissue. An engineered DNA sequence shows promise as one of the tools in a method to target brain tumour cells. New cancer therapies are needed that do not harm healthy tissue. An engineered DNA sequence shows promise as one of the tools in a method to target brain tumour cells.

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In this article, Jauch and colleagues show that glutamate 57 is essential to preserve the DNA binding mechanism of SOX17. Mutations at this site into diverse amino acids turn SOX17 into a powerful alt...