Nature Reviews Gastroenterology & Hepatology, Published online: 21 April 2026; doi:10.1038/s41575-026-01203-xThis Review outlines the role of gut–brain signalling in eating behaviour and obesity, highlighting gut-derived signals and cues relevant during eating phases. Underlying mechanisms of this gut–brain communication are discussed alongside the key role of the vagus nerve in this process.

Nature Reviews Gastroenterology & Hepatology, Published online: 15 April 2026; doi:10.1038/s41575-026-01208-6A new Consensus Statement puts forward a definition of ‘gut health’ in an attempt to bring some clarity and consistency to a term that is widely used but often ill-defined and vague.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 March 2026; doi:10.1038/s41575-026-01187-8Current drug approvals reshape metabolic dysfunction-associated steatohepatitis (MASH) therapeutic strategies. This Review highlights current and emerging therapeutic targets and discusses a mechanism-based framework for personalized, combination-oriented management in MASH.

Nature Reviews Gastroenterology & Hepatology, Published online: 17 March 2026; doi:10.1038/s41575-026-01189-6‘Gut health’ is a widely used term, but there is much uncertainty and inconsistency related to its use. An international panel has now provided a definition that includes consideration of both gastrointestinal function and symptom burden. While advancing the field, the definition also prompts a number of areas of debate.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 March 2026; doi:10.1038/s41575-026-01187-8Current drug approvals reshape metabolic dysfunction-associated steatohepatitis (MASH) therapeutic strategies. This Review highlights current and emerging therapeutic targets and discusses a mechanism-based framework for personalized, combination-oriented management in MASH.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 March 2026; doi:10.1038/s41575-026-01192-xPhysical activity and the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 February 2026; doi:10.1038/s41575-026-01176-xThis Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term in the context of therapeutic interventions.

The secretory heparan sulphate proteoglycans perlecan, agrin, collagen18A1 are expressed in the periganglionic sheath of enteric ganglia in resectates of Hirschsprung's disease patients and non-Hirsc...

Nature Reviews Gastroenterology & Hepatology, Published online: 18 February 2026; doi:10.1038/s41575-026-01176-xThis Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term in the context of therapeutic interventions.

Nature Reviews Gastroenterology & Hepatology, Published online: 11 February 2026; doi:10.1038/s41575-026-01180-1Nutritional maintenance therapy for paediatric patients with Crohn’s disease

Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

Nature Reviews Gastroenterology & Hepatology, Published online: 22 January 2026; doi:10.1038/s41575-026-01173-0Protein is an essential nutrient in the human diet. This Review explores the fate of dietary protein in the gastrointestinal tract and its influence on colonic health and disease, providing insights into dietary protein metabolism, digestion, absorption, fermentation and the implications for colonic health.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 January 2026; doi:10.1038/s41575-025-01164-7Glycans are essential components of the gut mucosa that modulate epithelial barrier integrity, host–microbiota interactions and gut immune response. This Review discusses the role of mucosal glycans in gut homeostasis, in intestinal inflammation and their therapeutic potential for inflammatory bowel disease.