iiinova — where your digital self keeps evolving

Rafa Argüello @rafajarguello.bsky.social · 19/06/2025

Great pleasure to finally meet and discuss in person with the one and only PC (what's his blue sky?) today at @ciml.bsky.social . I hope you enjoy your time! in the photo he looks like singing, but not, is just rocking it PC is another great member of our @immunometeurope.bsky.social !

020

Rafa Argüello @rafajarguello.bsky.social · 02/06/2025

Congratulations Nicolas ! I just seen this and I will read in detail, but... I wonder, what is the advantage for viruses to target the centromere proteins? they inhibit silencing machinery there? hmm 🤔.. is that known?

110

Reposted by Rafa Argüello

Centre d'Immunologie de Marseille Luminy @ciml.bsky.social · 30/04/2025

🔬 🦠 Check this great scientific meeting organized by Carolyn King and CIML's team leader Mauro Gaya. @immunologyking.bsky.social @maurogaya.bsky.social

055

Rafa Argüello @rafajarguello.bsky.social · 01/04/2025

Thanks Antonio, it was such a pleasure to share our work in your conference. 🙏🤗

010

Rafa Argüello @rafajarguello.bsky.social · 31/03/2025

So many great talks today! to the Organizers @Nuria Martínez-Martín, @Fernando Martin Belmonte et al. @Centro de Biología Molecular Severo Ochoa, CBM @cnrs.fr #Innovation #Metabolism @agencerecherche.bsky.social (Agence nationale de la recherche)

110

Rafa Argüello @rafajarguello.bsky.social · 31/03/2025

Happy to be at the Spanish "Cell Metabolism Network" conference in Madrid. Tomorrow I will be closing the conference and sharing what we are doing at CIML sharing work of 💪: Ro Lavignolle Heguy, Pau G González, Raph CHAPUY & Felipe Flores Santibáñez and @gammaomics.bsky.social

180

Reposted by Rafa Argüello

Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 10/03/2025

It’s the start of a new week. But we still want more labcoats and less white robes. We need to keep standing up for science! @standupforscience.bsky.social @marionlegrand.bsky.social @rafajarguello.bsky.social @cnrs.fr @inserm.fr @univ-amu.fr @crcm.bsky.social @ciml.bsky.social #Medsky

Selfie of 3 persons at a « Stand up for Science » March in the middle of a crowd of pacific demonstrator. One of the 3 persons is holding a sign that says « more labcoats and less white robes » written in French and showing an actual labcoat next to KKK white robes.

0202

Rafa Argüello @rafajarguello.bsky.social · 19/02/2025

Very happy on my way to Davos to Share our latest research and developments we are doing at @ciml.bsky.social and @gammaomics.bsky.social at the Swiss Institute of Allergy and Asthma Research and discuss with Milena Sokolowska, team and SIAF PIs. ++On the ✈️ next to a colleague by chance! 👨‍🔬🌎🤏

030

Rafa Argüello @rafajarguello.bsky.social · 18/02/2025

I have been so sick! lost the sense of smell and taste. I don't appreciate tastes but only textures in my mouth. My father lost his sense of smell in an accident (11yo). However, He enjoys food more than average people. How come? did he forgot what tastes good and created a new scale in his brain?

120

Reposted by Rafa Argüello

Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 15/02/2025

Today is the international day against childhood cancer. To honor the 2,500 children and adolescents diagnosed with cancer each year in France, scientists from @crcm.bsky.social, @aphm-chu-marseille.bsky.social & @inp-marseille.bsky.social ran 15km this morning in Marseille to draw 2500 in GPS 💪🏻

1204

Rafa Argüello @rafajarguello.bsky.social · 30/01/2025

objectively speaking, you mean.. no? 😜

000

Reposted by Rafa Argüello

Rafa Argüello @rafajarguello.bsky.social · 29/01/2025

Thanks a lot Eddy for your kind words. My pleasure to work with you, Marion and all this great community, altogether committed to help fighting Pediatric Cancers, .. is inspiring!!

031

Rafa Argüello @rafajarguello.bsky.social · 29/01/2025

Thanks a lot Eddy for your kind words. My pleasure to work with you, Marion and all this great community, altogether committed to help fighting Pediatric Cancers, .. is inspiring!!

031

Reposted by Rafa Argüello

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 25/01/2025

If you’re looking at what’s happening in the US, seeing Musk considering making massive donations to Reform & trying to subvert our democracy, and are rightly horrified, might I recommend signing this - petition.parliament.uk/petitions/70...

petition.parliament.uk

Petition: Tighten the rules on political donations

We want the government to: Remove loopholes that allow wealthy foreign individuals to make donations into UK political parties (e.g. by funnelling through UK registered companies). Cap all donations ...

7146105

Reposted by Rafa Argüello

Jonathan Kipnis @jonykipnis.bsky.social · 25/01/2025

We have two postdoc positions in the lab: We are looking for neuroscientist with expertise in circuits, and for molecular virologist. If you are excited to apply your expertise to questions in neuroimmunology, please reach out for details. Please retweet.

01412

Reposted by Rafa Argüello

Carolyn King @immunologyking.bsky.social · 19/12/2024

Registration is live!! May 30th deadline for #EMBOTissueImmunity in Basel🇨🇭 (home to Eurocup 2025, Eurovision 2025, Art Basel, world renowned architecture and muuuuuch more!) Be our guest for groundbreaking #immunology discussion, swimming & fun along the Rhine. meetings.embo.org/event/25-bar...

03215

Rafa Argüello @rafajarguello.bsky.social · 23/01/2025

Why don't you make songs from your papers? and share them here? it's lots of fun :)

100

Rafa Argüello @rafajarguello.bsky.social · 23/01/2025

hahaha it's art, don't confuse with the rest.. Claude Bernard said: "Art is I, Science is We" I agree, but would rephrase: "Art is AI, Science is We"

100

Reposted by Rafa Argüello

Peter Cook @drpetercook.bsky.social · 25/11/2024

First 🦋 post (great to join everyone here) about our paper that's been published in JACI: www.jacionline.org/article/S009... Check it out if you have ever wondered how fungal spore growth controls how dendritic cells (clearly THE best immune cell) trigger inflammation that causes asthma...

jacionline.org

DEFINE_ME

44015

Reposted by Rafa Argüello

Achille Broggi🧪👨🏼‍🔬🔬 @achillebro.bsky.social · 21/01/2025

If you want to see our work presented directly from the primary source, @julienmambu.bsky.social will be giving a free webinar on Feb 6th at 5 PM CET as part of the Thursday seminar series of the French Society of Immunology #SFI sign up here: zoom.us/webinar/regi...

086

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

hahah thanks Joaquin! It was a lot of work even if AI helped a lot :)! Which is your favourite? Video/Figure 1, 2, 3, 4, 5 or 6?

100

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

Thanks to the @ciml.bsky.social and all our collaborators @cnrs-dr12.bsky.social IGH, C3M.. I also want to thanks to Claude Bernard that inspired me for this post: "Art is AI, Science is We" (Rafa J. Argüello)

010

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

I propose you do the same with your next pre-pring and let´s make scientific publications and sharing results also part of the creative process. I can also share how I did this.. but I also let you create your own way ;)

110

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

6/ "We hypothesized that patients with high expression levels of XBP1 target genes might resist Bortezomib more effectively. Our research in clinical trials confirmed this, predicting patient survival with bortezomib—but not with other drugs, highlighting the specificity of our findings. "

110

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

5/6 "Stress can lead to cell death or survival. Chemotherapies like bortezomib induce ER stress" We discovered a subpopulation of bortezomib-resistant cells that survive, reliant on IRE-1, raising questions about the role of IRE1 and XBP1 in patient survival under bortezomib treatment."

100

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

4/6 "Using SNUPR, we observed diverse cellular responses to the same stress: some cells block protein translation, others pause and recover, while some don’t stop at all. Not all induce XBP1 translocation—some massively do. Discover much more about their intricate interactions in our paper! 📑"

100

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

"Western blot and qPCR are bulk and can be tedious, so we developed SNUPR" Think of it like flow cytometry, but for nuclei. SNUPR allows to more efficiently track transcription factor translocation, and translation without cytoplasmic interference, offering clearer, more specific results."

110

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

2/6 ER stress starts with the accumulation of misfolded proteins in the ER. This results in the activation of sensors that mediate molecular responses, resulting in cell adaptation or cell death. The interplay between sensors and resulting cellular responses are challenging to study, SO..

100

Rafa Argüello @rafajarguello.bsky.social · 21/01/2025

1/6📣 1st thread in the BlueSky! Speakers ON! To honor his creative PhD : A blend of videos & with lyrics based on our latest research: Enjoy & 🙏 share! Single-Nuclei Analysis of the Unfolded Protein Response (#SNUPR): Revealing BTZ Resistance in Multiple Myeloma www.biorxiv.org/content/10.1...

3127

Reposted by Rafa Argüello

Caetano Reis e Sousa @reisesousalab.bsky.social · 06/01/2025

Happy New Year! I am a newly-arrived refugee from the other platform. Looking forward to (re-)connecting with friends and colleagues in this community!

610820

Rafa Argüello @rafajarguello.bsky.social · 13/12/2024

Such a great pleasure to had this intense agenda today, full amphi and sharing so many discussions with dear colleagues at @institutcurie.bsky.social Thanks Ana Maria Lenon and @elianepiaggio.bsky.social for the invitation!! and all for the warm reception and interesting exchanges!! 🥰🤩🤗🤗🤗

160

Reposted by Rafa Argüello

Maria Ermolaeva @mariaermolaeva.bsky.social · 12/12/2024

Can one become too old for healthy aging? In our recent review, we explore possible age limitations of the current longevity treatments. www.nature.com/articles/s44...

nature.com

Too old for healthy aging? Exploring age limits of longevity treatments - npj Metabolic Health and Disease

npj Metabolic Health and Disease - Too old for healthy aging? Exploring age limits of longevity treatments

7126

Reposted by Rafa Argüello

SouthROCK @southrock.bsky.social · 12/12/2024

First up, @marionlegrand.bsky.social and @rafajarguello.bsky.social present their collaborative project studying the metabolic heterogeneity of #Neuroblastoma, recently funded by the national cancer institute (INCa)

1103

Reposted by Rafa Argüello

Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 12/12/2024

Excited to be opening the first annual seminar of @southrock.bsky.social, the Lyon-Marseille Center of Excellence in Pediatric Oncology Research. What have we been up to over the first 12 months of existence and where do we go from there? Sky is the limit 🤩

072

Reposted by Rafa Argüello

Rita Strack @ritastrack.bsky.social · 06/12/2024

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

nature.com

Method of the Year 2024: spatial proteomics - Nature Methods

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

3613170

Rafa Argüello @rafajarguello.bsky.social · 19/11/2024

This is nice! How do you get added to this lists?

130