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Marion

@marionlegrand.bsky.social
315 followers 783 following 30 posts

PharmD, PhD, childhood cancer biology and experimental therapeutics 👩🏻‍🔬🔬💊, member of REACT-4Kids - mindset is everything ❣️🍀

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Reposted by Marion
bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 10/01/2026
Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastoma www.biorxiv.org/content/10.64898/20…
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bioRxivpreprint @biorxivpreprint.bsky.social · 10/01/2026
Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastoma www.biorxiv.org/content/10.64898/20…
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Marion @marionlegrand.bsky.social · 01/09/2025
Depuis plusieurs années, le mois de septembre est dédié à la lutte contre les cancers de l’enfant, de l'adolescent et du jeune adulte (AJA). Pour parvenir à guérir plus et mieux, parlez en autour de vous et faites entendre la voix des enfants malades.
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Marion @marionlegrand.bsky.social · 23/07/2025
This study is another POC for the interest of our program realized through @southrock.bsky.social evaluating the physical activities in children diagnosed with cancer. Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | New England Journal of Medicine www.nejm.org/doi/full/10....
nejm.org
Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...
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Marion @marionlegrand.bsky.social · 22/06/2025
One picture is worth a thousand words
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Marion @marionlegrand.bsky.social · 03/06/2025
📣 Youth4Kids 2025 🎗️ @r4knetwork.bsky.social This morning, we had the pleasure to welcome Dr Clara Savary from @hmriaustralia.bsky.social. She is currently working on deciphering the resistance mechanisms of ONC201 in DIPG. Well done Clara and the whole team led by Dr Matt Dun. 👏
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Marion @marionlegrand.bsky.social · 02/06/2025
📣 Youth4Kids 2025 🎗️Best young researcher talk 🤩 Second part of the contest. Five new candidates will be presenting their work. @r4knetwork.bsky.social
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Marion @marionlegrand.bsky.social · 02/06/2025
📣 Youth4Kids 2025 🎗️Best young researcher talk 🤩 This year, 10 candidates will be presenting their work. They will be judged by young postdocs from the @r4knetwork.bsky.social. We are starting this morning with 4 PhD candidates. Good luck to all candidates.
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Marion @marionlegrand.bsky.social · 02/06/2025
📣 Youth4Kids 2025 🎗️ Let's start with @guixe-m.bsky.social from @irbbarcelona.org. Her work focuses on the origin of second malignancies in children or the factors underlying the response to immunotherapies. Looking forward to listening to her talk! @r4knetwork.bsky.social
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Marion @marionlegrand.bsky.social · 02/06/2025
Here we go again!! 🤩 Today is the first day of Youth4Kids 2025!!! An online congress organized by the young researchers of @r4knetwork.bsky.social. Great keynote speakers, selected talks from young researchers and the highlight of the event, the Youth4Kids Doctoral Grant Competition!!!
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React4Kids @r4knetwork.bsky.social · 31/03/2025
In this week’s publication highlights, we picked this study just out @naturemedicine.bsky.social describing an innovative method for the rapid classification of brain tumors based on molecular profiling. Congrats to all involved @dkfz.bsky.social and beyond 👏🏻 www.nature.com/articles/s41...
nature.com
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine
Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling w...
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Marion @marionlegrand.bsky.social · 29/03/2025
Looking for heart shapes in the lab and in life in general. Life is full of beauty. Notice it.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 27/03/2025
For the first time of the year, the whole team got together for the #REMAP4Kids Mini-Symposium. Full afternoon of short presentations to highlight the different projects ongoing in the team. Very exciting to see how our team is progressing over the years, thanks to our collaborations & funders.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 25/03/2025
Today, members of @r4knetwork.bsky.social gave presentations to school pupils all across the country. We’re teaching young kids about medical research & what it means to be a scientist. Always a great pleasure and even more so with our brand new lab member @mathilde-krh.bsky.social 🤩.
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Marion @marionlegrand.bsky.social · 25/03/2025
Chaque année au mois de Mars, sous l’impulsion 2500 Voix les chercheurs du réseau React4Kids se mobilisent pour sensibiliser les enfants des classes primaires et collèges sur la recherche, le cancer et leur donner envie de s’engager dans des métiers au service des autres.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 19/03/2025
Our collabs are the best! Headed by Laura Broutier from CRCL & funded by INCa, this collaborative project uses patient-derived tumoroids, drug screening and mathematical modeling to develop more effective treatments for #Rhabdomyosarcoma. This is so @southrock.bsky.social 🤩
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 11/03/2025
Every single one of these meetings is an absolute pleasure. I feel privileged to coordinate this Center of Excellence with @marie-castets.bsky.social and to get to build collaborative projects with the likes of @cedricmaurange.bsky.social @delloye-bourgeois.bsky.social & many more not on BlueSky.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 10/03/2025
It’s the start of a new week. But we still want more labcoats and less white robes. We need to keep standing up for science! @standupforscience.bsky.social @marionlegrand.bsky.social @rafajarguello.bsky.social @cnrs.fr @inserm.fr @univ-amu.fr @crcm.bsky.social @ciml.bsky.social #Medsky
Selfie of 3 persons at a « Stand up for Science » March in the middle of a crowd of pacific demonstrator. One of the 3 persons is holding a sign that says « more labcoats and less white robes » written in French and showing an actual labcoat next to KKK white robes.
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Marion @marionlegrand.bsky.social · 08/03/2025
Today is the International Women's Day 2025. The world we are currently living in scared me a little more every day, but collectively, I still do think that we can make a difference. I wish we could live in a gender equal world. #IWD2025
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Marion @marionlegrand.bsky.social · 07/03/2025
Today, I protested against Trump administration’s science policies. Science, all types of science, shapes our world, our futur world. We need to protect it. Science always matters. @standupforscifr.bsky.social @crcm.bsky.social @cnrs.fr @inserm.fr
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Christophe 🔬 Leterrier @christlet.bsky.social · 07/03/2025
More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025
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Marion @marionlegrand.bsky.social · 06/03/2025
Je serai présente au rassemblement marseillais du mouvement #StandUpForScienceFrance ce vendredi.   Mobilisons nous pour défendre les sciences et les humanités, la liberté académique, la recherche et l’enseignement.
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Reposted by Marion
Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 04/03/2025
Glad to have contributed to this beautiful work led by @celiarouault.bsky.social & colleagues at @crcm.bsky.social just out in @naturecomms.bsky.social. Using drug repurposing, they unveiled the STAT3/FanA axis as a targetable vulnerability in breast cancer stem cells www.nature.com/articles/s41...
nature.com
Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer - Nature Communications
Targeting cancer stem cells (CSCs) has great potential in anti-cancer treatment. Here this group reports the role of antibiotic Nifuroxazide as a potent anti-CSC compound and fabricates it into an ant...
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SouthROCK @southrock.bsky.social · 25/02/2025
Today, all 3 centers of excellence in pediatric oncology research were invited by INCa to present what they have been up to during their first year of existence. We were delighted to showcase everything we have put in place, including our beloved #RockBands, ongoing and upcoming projects.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 24/02/2025
ALERT NEW COMER!! @r4knetwork.bsky.social, the French network for basic and translational research in pediatric oncology is finally on @bsky.app 🎉 We will be posting all our upcoming events, including free webinars & annual conferences, as well as new publications, job ads… So, watch this space 👀
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React4Kids @r4knetwork.bsky.social · 24/02/2025
Our free webinars are back! Today we had the pleasure of listening to Dr Ulrich Schüller from the Research Institute Children’s Cancer Center Hamburg, talking about his work on the molecular diversity of spinal ependymomas.
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Marion @marionlegrand.bsky.social · 23/02/2025
Movies you’ve watched more than six times, gifs only
media.tenor.com
a man is wearing a hat and a tank top and says hello
ALT: a man is wearing a hat and a tank top and says hello
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 23/02/2025
Retour en images sur la journée du 15 Février et la petite sortie des coureurs amateurs du @crcm.bsky.social pour rendre hommage aux 2500 enfants diagnostiqués avec un cancer chaque année en France. Un beau moment de partage et de sensibilisation youtu.be/Nm66kbd8_Vk?...
youtu.be
✦ REPORT ✦ 2500 VOIX ✦ ENGAGEMENT ✦ Strava Drawing
YouTube video by Serge Fortini
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 15/02/2025
Today is the international day against childhood cancer. To honor the 2,500 children and adolescents diagnosed with cancer each year in France, scientists from @crcm.bsky.social, @aphm-chu-marseille.bsky.social & @inp-marseille.bsky.social ran 15km this morning in Marseille to draw 2500 in GPS 💪🏻
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Marion @marionlegrand.bsky.social · 09/02/2025
📣 Dans le cadre du Live Stream **NON-STOP** de 27h sur les réseaux sociaux pour la journée internationale des cancers pédiatriques, le 15 Février prochain, plusieurs évènements artistiques **gratuits** vont avoir lieu à l'Hôpital de la Timone, dans le hall de Timone 2.
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Marion @marionlegrand.bsky.social · 08/02/2025
Le 15 février, journée mondiale des cancers pédiatriques!! **27h** de Live Stream **NON-STOP** sur les réseaux sociaux pour témoigner, parler de la recherche et du soin, et pour sensibiliser, porter leur voix et leur combat. Soyez là! On compte sur vous!! Partagez!!
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Darby Saxbe @darbysaxbe.bsky.social · 04/02/2025
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
list of banned keywords
12652769415654
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SouthROCK @southrock.bsky.social · 29/01/2025
Last but not least, the 9th #RockBand is everything cancer metabolism. From defining metabolic vulnerabilities in pediatric cancers, the impact of metabolic inhibitors on developmental pathways and the slightly reverse impact of developmental alterations on cell metabolism. 1/2
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 28/01/2025
First get together of (part of) the REMAP4Kids team for 2025. Celebrating the departure of our beloved PhD student Baptiste Mouysset and the arrival of our Master student Florent Sauteret.
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SouthROCK @southrock.bsky.social · 23/01/2025
How do you break the century-old frontier between medical #Hematology and #Oncology? In our Centre of Excellence we will try to break barriers and build true transdisciplinary projects to improve the care and prevention in pediatric oncology. For that, we created the #RockBand « Crossroads ». 1/2
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SouthROCK @southrock.bsky.social · 23/01/2025
This one is for the open-minded! It will bring together experts in 3 major fields of medical research: #Hematology, #Oncology & #Immunology to make the most of the skill sets, tools & models available in our Center. It is led by @marionlegrand.bsky.social, Sarah Benezech & Carine Halfon-Domenech.
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SouthROCK @southrock.bsky.social · 20/01/2025
Time to introduce our 5th #RockBand. An hommage to the legendary Doors, this 20-piece band will focus on critical Windows of susceptibility during pregnancy and early childhood, pre-disposition factors, the notion of clusters, the prediction of long-term sequelae & prevention 1/2
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SouthROCK @southrock.bsky.social · 16/01/2025
Another day, another RockBand 🤘🏻 Now that @cedricmaurange.bsky.social is here we can introduce the Comets, the band he co-directs with Laura Broutier. This band is for the lovers of cell fate and trajectories. 1/2
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SouthROCK @southrock.bsky.social · 15/01/2025
To celebrate the arrival of @delloye-bourgeois.bsky.social on BlueSky, let’s introduce our 3rd RockBand that she co-directs with Virginie Marcel: Rage against the Mesenchyma is obviously an hommage to the legendary metal band that was really upset with their printer. 1/2
The name “Rage against the Mesenchyma” written on an orange background using the font of the band Rage Against the Machine
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Marion @marionlegrand.bsky.social · 12/01/2025
Tumour cells have great flexibility in reprogramming their metabolism. Immune cells too! Still a lot to do before revealing the complexe interplay between metabolic pathways and between cancer and immune cells. Great review written by @jer-06.bsky.social to better understand these interactions.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 31/12/2024
Gentle reminder. Selling lies to people, whether you’re a self-proclaimed genius scientist or a bullshit politician, is indeed the same thing. People have asked for 5 years “how do you get to 3,000 publications?” - en publiant de la merde, that’s how.
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Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · 20/12/2024
Imagine being the richest man on Earth and so you can earn a few extra billions you are willing to kill the funding of #ChildhoodCancer researcher. I know it’s hard to imagine that someone could be so heartless, despicable and mean. But imagine… #Elonisatwat www.thebulwark.com/p/elon-musk-...
thebulwark.com
Elon Killed the Budget Deal. Cancer Research for Kids Was Collateral Damage.
Advocates were celebrating the inclusion of money and provisions to help fund pediatric research. And then the tweets started.
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Marion @marionlegrand.bsky.social · 02/12/2024
We are looking for a Research Assistant in cell culture and molecular biology to work on an exciting project bridging innate immunity cells and neuroblastoma. Please share! @crcm.bsky.social @cnrs.bsky.social #INSERM #Aix-Marseille-University
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SouthROCK @southrock.bsky.social · 17/12/2024
Introducing our second #RockBand: the BEATLS, as in Brainstorming for the Elaboration of Ancillary and Translational Studies. As its acronym indicates this band is in charge of everything translational in our Center: turning fundamental discoveries into novel therapeutic opportunities.
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SouthROCK @southrock.bsky.social · 16/12/2024
Introducing our first #RockBand Entirely dedicated to studying the impact of adapted physical activity (APA) throughout life, the #RunningStones is made of pediatric oncologists and muscle biologists. Together they will define how APA can improve muscle health and treatment tolerance.
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Marion @marionlegrand.bsky.social · 13/12/2024
Two working days for improving global care of pediatric cancer patients. Grateful to be part of this wonderful consortium gathering great scientists and wonderful human beings.
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SouthROCK @southrock.bsky.social · 12/12/2024
First up, @marionlegrand.bsky.social and @rafajarguello.bsky.social present their collaborative project studying the metabolic heterogeneity of #Neuroblastoma, recently funded by the national cancer institute (INCa)
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Marion @marionlegrand.bsky.social · 02/12/2024
We are looking for a Research Assistant in cell culture and molecular biology to work on an exciting project bridging innate immunity cells and neuroblastoma. Please share! @crcm.bsky.social @cnrs.bsky.social #INSERM #Aix-Marseille-University
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Marion @marionlegrand.bsky.social · 01/12/2024
Décembre pour rêver et tous les autres mois aussi 🤩🤩. #childhoodcancer #cancersurvivor #christmas www.instagram.com/reel/DDC2N7x...
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