iiinova — where your digital self keeps evolving

Prisca Liberali @priscaliberali.bsky.social · 08/09/2026

Biology × physics × modelling × AI 📍 Thun | 21–25 March 2027 🗓 Apply by 10 Dec

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Prisca Liberali @priscaliberali.bsky.social · 08/09/2026

How do tissue-level dynamics shape cell behaviour? And how does robust biological organization emerge across scales?

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Prisca Liberali @priscaliberali.bsky.social · 08/09/2026

What if we stop asking only how cells build tissues and ask how tissues shape cells? That’s what we’ll explore at Modelling Life from Tissues to Cells 🇨🇭 lakeconferences.org/conf/8334d9b...

lakeconferences.org

Conference - Modelling Life from Tissues to Cells: Coordination and Robustness - Lake Conferences

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FMI science @fmiscience.bsky.social · 13/07/2026

Now out in Cell @cellpress.bsky.social: Researchers in the @priscaliberali.bsky.social lab & collaborators at @istaresearch.bsky.social show how regenerating gut tissue turns small cellular differences into stable patterns, revealing a broader principle of tissue repair. www.fmi.ch/news-events/...

fmi.ch

How the gut rebuilds order after injury

FMI researchers and their collaborators have shown how regenerating intestinal tissue turns small initial differences between cells into stable patterns. The findings reveal a general principle for ho...

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Prisca Liberali @priscaliberali.bsky.social · 30/06/2026

FOXA1 reads out the YAP1 state and couples it to Delta–Notch feedback, generating fate bistability. That bistability stores a memory of transient YAP1 activity — converting fleeting heterogeneity into stable, self-organized tissue architecture. 🧬

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Prisca Liberali @priscaliberali.bsky.social · 30/06/2026

Using mouse intestinal regeneration + organoids, we find a critical intermediate tissue density acts as a regenerative timer: only in this window does heterogeneity in the mechanosensor YAP1 emerge, encoding lineage-biased competence at the chromatin level.

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Prisca Liberali @priscaliberali.bsky.social · 30/06/2026

After injury, intestinal cells lose their identity and the tissue has to rebuild its pattern from scratch. Classic theory assumes a "blank slate" of identical cells — but real cells are heterogeneous from the start.

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FMI science @fmiscience.bsky.social · 02/06/2026

Our seminar room was almost overflowing for the third Friedrich Miescher Lecture, hosted by @priscaliberali.bsky.social and delivered by Ewa Paluch from @cam.ac.uk. Paluch gave a fascinating talk on cell shape and the cross-talk between cell shape and cell fate 🔬🧫

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Prisca Liberali @priscaliberali.bsky.social · 26/11/2025

Miki Ebisuya, TU Dresden EMBL Mukund Thattai, NCBS Nicoletta Petridou, EMBL Paul François, McGill Rashmi Priya, Crick Sara Wickström, MPI Takashi Hiiragi, Hubrecht Institute Wendell Lim, UCSF Yanlan Mao, MRC

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Prisca Liberali @priscaliberali.bsky.social · 26/11/2025

Jennifer A. Lewis, Harvard Jesse Veenvliet, MPI Jun Allard, UCI Karen Alim, MPI L. (Maha) Mahadevan, Harvard Matthias Lutolf, EPFL Michael Elowitz, Caltech Miguel L. Concha, Universidad de Chile

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Prisca Liberali @priscaliberali.bsky.social · 26/11/2025

Still some doubts 😊here the list of speakers Alan Lowe, CZI Alex Schier, Biozentrum Allon Klein, Harvard Amy Shyer, The Rockefeller Arthur Lander, UCI Christina Theodoris, Gladstone Dana Pe’er, MSKCC Ewa Paluch, Cambridge Giovanni D’Angelo, EPFL James Briscoe, Crick

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Prisca Liberali @priscaliberali.bsky.social · 26/11/2025

The deadline to apply for the Lake Conference on Modeling Life from Cells to Tissues is just few weeks away! Apply to attend by December 12: alleninstitute.org/events/aics-...

alleninstitute.org

2026 Lake Conference

Join the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...

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Prisca Liberali @priscaliberali.bsky.social · 26/11/2025

Modeling Life from Cells to Tissues

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Prisca Liberali @priscaliberali.bsky.social · 26/11/2025

Emergence and Self-organisation across biological scales! I hope you are ready for next year conference! It will be an incredible event April 20-22 2026. The first of many #LakeConference organised by @ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org

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paveltomancak.bsky.social @paveltomancak.bsky.social · 21/08/2025

The last day of lectures at #LISH25 starts with Gustavo Medeiros presenting applications of light sheet microscopy to #organoid research. @priscaliberali.bsky.social lab. Gustavo is a physicist and a creative artist and the walk-up song delivers that message. Video in thread.

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FMI science @fmiscience.bsky.social · 11/06/2025

🚨We're hiring! Join a global team at the @priscaliberali.bsky.social lab & the @alleninstitute.org to build cutting-edge image analysis workflows for complex biological datasets, including light-sheet microscopy images. Apply at: www.fmi.ch/education-ca...

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FMI science @fmiscience.bsky.social · 12/06/2025

We're seeking a Research Associate in stem cell biology to join a global, interdisciplinary team investigating organoids and tissue organization. This unique role is part of a collaboration between the @priscaliberali.bsky.social lab & the @alleninstitute.org. Apply at: www.fmi.ch/education-ca...

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FMI science @fmiscience.bsky.social · 25/03/2025

In @naturephysics.bsky.social, researchers from @priscaliberali.bsky.social's lab and @ehannezo.bsky.social's group reveal how intestinal organoids form crypts, key to gut regeneration and stability. Their work could impact tissue engineering and regenerative medicine. www.fmi.ch/news-events/...

fmi.ch

Shaping the gut: how tissue mechanics drives intestinal organoids formation

FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have broader implications fo...

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Prisca Liberali @priscaliberali.bsky.social · 12/03/2025

Super retreat! And don’t miss the paper on robustness in crypt morphogenesis 🤩

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Edouard Hannezo @ehannezo.bsky.social · 10/03/2025

Fun group retreat in the Austrian alps with @priscaliberali.bsky.social! And perfect time to celebrate our new joint paper (from Shi-Lei Xue & Qiutan Yang) out on how mechanochemical bistability confers robustness to intestinal organoids! www.nature.com/articles/s41... - see 🧵! (1/n)

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Prisca Liberali @priscaliberali.bsky.social · 01/02/2025

Don’t forget to apply! This is an amazing opportunity!

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

This shows that transient heterogeneity establishes a regulatory framework essential for proper intestinal regeneration and could be a general principle underlying a wide range of regenerative processes.

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

We developed mathematical models showing how YAP1 and FOXA1 drive bistable states, allowing cells to "lock in" their fates. A feedback loop ensures long-term pattern stability and confers memory to the system.

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

And FOXA1 role is essential to exit a default state of differentiation.

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

YAP1 heterogeneity primes secretory progenitor cells, setting the stage for robust patterning. This involves chromatin remodelling, creating a favourable environment for FOXA1, a critical transcription factor.

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

When tissue density hits a critical level, YAP1 activity becomes heterogeneously inactivated. This cell-to-cell variability is essential for triggering the first cell fate decisions via chromatic remodelling and Delta-Notch signalling.

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

We also made a Yap activity fluorescent reporter organoid line to look into the dynamics at the tissue scales!

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

Using in vitro organoids and in vivo mouse models, we uncovered that mechanosensor YAP1 acts as a molecular "pre-patterner" cue during regeneration.

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

Tissue regeneration is driven by cells transitioning from homogenous regenerative cells to a patterned crypt. But actually cell-to-cell variability plays a super important role for the return to homeostasis!

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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

biorxiv.org

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 16/12/2024

Join us at FMI as a Junior Group Leader! A unique opportunity to set up your lab in a vibrant international research institute with world-class research groups and facilities, generous core funding, a collegial and inclusive culture - and great colleagues 🤓!

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Prisca Liberali @priscaliberali.bsky.social · 16/12/2024

We have a new opening! Amazing environment colleagues and facility! Join us!

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Prisca Liberali @priscaliberali.bsky.social · 15/12/2024

Do you want to know how tissue is coordinated across space and time? Don’t miss Laura’s talk!

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Prisca Liberali @priscaliberali.bsky.social · 27/11/2024

My first post here to celebrate the lab and their achievements. What a fantastic night!

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