iiinova — where your digital self keeps evolving

Dr Poonam Thakur @poonamthakur.bsky.social · 30/08/2026

Happy to share our new publication in Molecular Neurobiology! Coffee and its compounds have been linked to neuroprotection in several neurodegenerative diseases. Chlorogenic acid (CA), a coffee-derived compound, has also shown promise in preclinical studies. link.springer.com/article/10.1...

link.springer.com

Chlorogenic Acid Fails to Confer Neuroprotection in a Chronic Mouse Model of Parkinson’s Disease - Molecular Neurobiology

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by α-synuclein (α-Syn) aggregation, dopaminergic neuronal loss, and chronic neuroinflammation. Chlorogenic acid (CA),...

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Dr Poonam Thakur @poonamthakur.bsky.social · 31/12/2025

After long days, failed experiments, and patient persistence, this year reminded us why we stay. The work found its voice—through publications, recognition, and shared wins. #grateful, #proud, and filled with hope as we step into the new year. #HappyNewYear2026 to all of you.

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Dr Poonam Thakur @poonamthakur.bsky.social · 07/11/2025

Pleased to share our new publication in Bioprotocol, where we describe a detailed method for generating the progressive #mouse model of #Parkinson’s disease combining rAAV-α-synuclein and preformed fibrils of α-synuclein. We hope this serves as a useful resource. bio-protocol.org/en/bpdetail?....

bio-protocol.org

A One-Step Mouse Model of Parkinson’s Disease Combining rAAV-α-Synuclein and Preformed Fibrils of α-Synuclein

Developing preclinical animal models that faithfully mimic the progressive nature of Parkinson’s disease (PD) is crucial for advancing mechanistic insights as well as therapeutic discovery. While reco...

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Dr Poonam Thakur @poonamthakur.bsky.social · 04/10/2025

Our latest study explores how lipid dysregulation links the brain and periphery in #Parkinson’s disease (PD). #Lipid imbalance is emerging as a hallmark of PD—but do peripheral lipid changes truly mirror what happens in the brain? www.biorxiv.org/content/10.1...

biorxiv.org

Integrative lipidomics of brain and plasma uncovers sex-specific metabolic signatures in Parkinson′s disease

Lipid dysregulation is increasingly recognized as a key feature of Parkinson′s disease (PD). A central unresolved question, however, is whether lipidomic signatures identified in accessible peripheral...

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Dr Poonam Thakur @poonamthakur.bsky.social · 23/09/2025

Can neurons bounce back after damage? A new study in @elife.bsky.social reveals that surviving dopamine SN neurons can restore full firing flexibility—once thought lost—with Kv4.3-mediated changes. Happy to have contributed to this seminal work. elifesciences.org/articles/104...

elifesciences.org

Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity

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Dr Poonam Thakur @poonamthakur.bsky.social · 13/09/2025

Excited to share our new paper in ACS Chemical Neuroscience. Through biophysical assays and in vivo studies, we show that glycation alters how α-synuclein drives pathology, leading to earlier symptom onset. This may help explain the higher PD risk in people with diabetes pubs.acs.org/doi/full/10....

pubs.acs.org

Glycated Alpha-Synuclein Assemblies Cause Distinct Parkinson’s Disease Pathogenesis in Mice

Alpha-synuclein (α-Syn) misfolding and aggregation are key drivers of Parkinson’s disease (PD) pathology. Mutations and certain post-translational modifications impact its aggregation propensity and p...

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Dr Poonam Thakur @poonamthakur.bsky.social · 27/08/2025

Thrilled to kick off our collaboration with @kmcostalab.com, supported by an Impact Award from @pfresearchteam.bsky.social. We will uncover how striatal dopamine contributes to cognitive decline in early stages of #Parkinsonsdisease. Exciting times ahead! @tvmiiser @bio_iisertvm

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Dr Poonam Thakur @poonamthakur.bsky.social · 06/07/2025

Grateful to @cureparkinsons.org.uk for this feature on #ResearchAppreciationDay & their continued support for our preclinical research program for #Parkinsons. Their commitment to advancing fundamental research that can inform future therapeutic strategies for PD is commendable. 🙏

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Dr Poonam Thakur @poonamthakur.bsky.social · 27/03/2025

I will be attending the Synuclein2025 meeting at Cambridge, UK. Looking forward to meeting fellow scientists and soaking in the latest research. Drop a DM if you would like to catch up during the meeting.

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Reposted by Dr Poonam Thakur

Marco A. Maximo Prado @maximoprado.bsky.social · 05/02/2025

We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.

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Dr Poonam Thakur @poonamthakur.bsky.social · 14/02/2025

1/n-Excited to share the first preprint of our lab. We created a robust mouse model of #PD by combining AAV6-α-synuclein overexpression with preformed fibrils injected into the substantia nigra. This model recapitulates key features of PD, enabling mechanistic & therapeutic studies. Key findings:

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Dr Poonam Thakur @poonamthakur.bsky.social · 30/11/2024

Hi fellow #educators, I will be teaching a #Physiology course to UGs for the first time. I hear many students find the subject boring or difficult. Please share some good resources, videos, animations, websites or any other tips that I can use to make the course engaging & useful. #teaching

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Dr Poonam Thakur @poonamthakur.bsky.social · 14/11/2024

Congratulations to my Phd student @Santhosh_subs for winning the travel award to attend @IndAcadNeurosci annual meeting. #IAN24 at NIMHANS. #proudPI

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Dr Poonam Thakur @poonamthakur.bsky.social · 09/11/2024

Hello #neuroscience community. I am an Assistant Professor at IISER-Thiruvananthapuram working on Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration #movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky

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Reposted by Dr Poonam Thakur

drug doc @pkpd-babe.bsky.social · 08/11/2024

Hi, I’m Monica, and I’m adding people in the fields of pharmacology, physiology, and #neuroscience to the science feed! If you’d like to be added, please respond to this post with proof that you’re in one of the fields mentioned above. Afterward, your posts with a 🧪 emoji will show up on the feed.

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Dr Poonam Thakur @poonamthakur.bsky.social · 18/10/2023

Hello #bluesky community. I am an Assistant Professor working in the field of Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration #movementdisorders #parkinson #proteinaggregation. #HiSciSky #AcademicSky

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