Sign in

PLOS Biology

@plosbiology.org
15K followers 7.2K following 3.1K posts

A leading life science journal that champions inclusive, high-impact research across all disciplines—from molecules to ecosystems. We offer innovative formats and collaborative editorial support to ensure your work achieves its full scientific impact.

PostsRepliesMedia
PLOS Biology @plosbiology.org · 11/10/2026
Symbiotic #rhizobia form nitrogen-fixing partnerships with #plant roots. This study by @albinteulet.bsky.social & @dromius.bsky.social uses structural modelling to predict how secreted proteins may mimic plant factors in a strategy shared with pathogens. 🧪 #AcademicSky #symbiosis plos.io/4j6bWj0
Network-based identification of structural units (SUs) present in multiple Nop effectors.
(A) Structural similarity network of the 96 structural units (SU) extracted from AlphaFold models of the 33 Nop effectors. Each node represents one region, and edges connect pairs of regions that are structurally similar with a TM-score above 0.5. Coloured circles delimit the 13 communities containing at least two members (SU1–SU13). The remaining grey nodes correspond to the 9 singleton units. (B–N) Overlays of all structural regions belonging to each community (SU1–SU13). The putative fold or function inferred from Foldseek analysis is indicated below each panel, with the number of occurrences in each community given in parentheses.
12511
PLOS Biology @plosbiology.org · 11/10/2026
How are the #temporal patterns of sounds represented across the #auditory system at millisecond scale? This study shows that distinct click-train patterns evoke discriminable behavioral and neural responses, mapping this across the brain. 🧪 #NeuroSky plos.io/4hTU6O5
Neuronal responses to temporally merged click-train and complex tones across cortical layers in A1 in the oddball paradigm.
Left: Distribution of current source density (CSI) in the oddball paradigm (RN10, TW50) across cortical layers: supra layer (layers Ⅰ/Ⅱ, n = 30, top row), middle layer (layers Ⅲ/Ⅳ, n = 176, middle row), and deep layer (layers Ⅴ/Ⅵ, n = 465, bottom row). Arrows point to the mean.
Right: Comparison of CSI among supra, middle, and deep layers.
061
PLOS Biology @plosbiology.org · 11/10/2026
What are the #epigenetic mechanisms regulating cellular proteostasis? This study shows that a subunit of the COMPASS histone methyltransferase complex controls ultradian proteostasis gene expression through methylation at #proteostasis gene promoters. 🧪 #AcademicSky plos.io/4emgONz
This research article is titled "The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics," by Syeda Kubra, Michelle Sun, William Dion, Yu Bian, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Lijun Liu, Ian Sipula, Jian-Hua Luo, Michael J Jurczak, Silvia Liu, Bokai Zhu
061
PLOS Biology @plosbiology.org · 11/10/2026
Poorly validated #antibodies generate misleading results and waste research resources. @johanduchene.bsky.social explores two new @PLOSBiology.org studies quantifying these costs and identifying solutions. 🧪 Article 1 plos.io/3Ui0czP Article 2 plos.io/4s1Ccxl Primer plos.io/4hQh7kI
This Primer is titled, "Better antibodies, better science" by Johan Duchêne.
072
PLOS Biology @plosbiology.org · 10/10/2026
Visualizing #RNA dynamics in living plant cells at single transcript resolution is limited by high background fluorescence. This study develops a high signal-to-noise imaging platform that overcomes this barrier, revealing mRNA trafficking dynamics. 🧪 #AcademicSky #imaging #plants plos.io/4ARoa5k
Confocal fluorescence microscopic image showing colocalization of dCas13X–SunTag (green) with smFISH signals (red). ACT2 mRNA was used as reporter RNA. Nuclei are stained with DAPI (blue).
image’s creator: Jiayu Zhang
0217
PLOS Biology @plosbiology.org · 10/10/2026
Symbiotic #rhizobia form nitrogen-fixing partnerships with #plant roots. This study by @albinteulet.bsky.social & @dromius.bsky.social uses structural modelling to predict how secreted proteins may mimic plant factors in a strategy shared with pathogens. 🧪 #AcademicSky #symbiosis plos.io/4j6bWj0
Network-based identification of structural units (SUs) present in multiple Nop effectors.
(A) Structural similarity network of the 96 structural units (SU) extracted from AlphaFold models of the 33 Nop effectors. Each node represents one region, and edges connect pairs of regions that are structurally similar with a TM-score above 0.5. Coloured circles delimit the 13 communities containing at least two members (SU1–SU13). The remaining grey nodes correspond to the 9 singleton units. (B–N) Overlays of all structural regions belonging to each community (SU1–SU13). The putative fold or function inferred from Foldseek analysis is indicated below each panel, with the number of occurrences in each community given in parentheses.
1155
PLOS Biology @plosbiology.org · 10/10/2026
How are the #temporal patterns of sounds represented across the #auditory system at millisecond scale? This study shows that distinct click-train patterns evoke discriminable behavioral and neural responses, mapping this across the brain. 🧪 #NeuroSky plos.io/4hTU6O5
Neuronal responses to temporally merged click-train and complex tones across cortical layers in A1 in the oddball paradigm.
Left: Distribution of current source density (CSI) in the oddball paradigm (RN10, TW50) across cortical layers: supra layer (layers Ⅰ/Ⅱ, n = 30, top row), middle layer (layers Ⅲ/Ⅳ, n = 176, middle row), and deep layer (layers Ⅴ/Ⅵ, n = 465, bottom row). Arrows point to the mean.
Right: Comparison of CSI among supra, middle, and deep layers.
051
PLOS Biology @plosbiology.org · 10/10/2026
What are the #epigenetic mechanisms regulating cellular proteostasis? This study shows that a subunit of the COMPASS histone methyltransferase complex controls ultradian proteostasis gene expression through methylation at #proteostasis gene promoters. 🧪 #AcademicSky plos.io/4emgONz
This research article is titled "The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics," by Syeda Kubra, Michelle Sun, William Dion, Yu Bian, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Lijun Liu, Ian Sipula, Jian-Hua Luo, Michael J Jurczak, Silvia Liu, Bokai Zhu
062
PLOS Biology @plosbiology.org · 10/10/2026
Poorly validated #antibodies generate misleading results and waste research resources. @johanduchene.bsky.social explores two new @PLOSBiology.org studies quantifying these costs and identifying solutions. 🧪 Article 1 plos.io/3Ui0czP Article 2 plos.io/4s1Ccxl Primer plos.io/4hQh7kI
This Primer is titled, "Better antibodies, better science" by Johan Duchêne.
040
PLOS Biology @plosbiology.org · 09/10/2026
Poorly validated #antibodies misdirect research, wasting an estimated billion dollars and millions of biological samples each year. In this multi-stakeholder Delphi consensus study, experts agree on priority practical fixes, and who should deliver them, by 2030. 🧪 #AcademicSky plos.io/3Ui0czP
Title: Actionable solutions to address antibody validation failures. By Katherine Blades, Michael Biddle, Robert Froud, Eva M Krockow, and Harvinder Virk.
253
PLOS Biology @plosbiology.org · 09/10/2026
Researchers often select antibodies based on previous use or peer recommendations. This study shows that poor #antibody validation contributes to substantial avoidable consumption of animal and human biological samples, proposing interventions to improve #reliability. 🧪 #AcademicSky plos.io/4s1Ccxl
Self-reported antibody validation practices among researchers. Distribution of IWGAV pillar usage among survey respondents (n = 107). Of 107 respondents, 77 (72.0%) used at least one IWGAV-aligned validation strategy, while 30 (28.0%) used no IWGAV pillars, relying instead on technical controls only (n = 26) or performing no validation (n = 4). Among IWGAV users, 44 used a single pillar, 22 used two pillars, 10 used three pillars, and 1 used five pillars.
145
PLOS Biology @plosbiology.org · 09/10/2026
Visualizing #RNA dynamics in living plant cells at single transcript resolution is limited by high background fluorescence. This study develops a high signal-to-noise imaging platform that overcomes this barrier, revealing mRNA trafficking dynamics. 🧪 #AcademicSky #imaging #plants plos.io/4ARoa5k
Confocal fluorescence microscopic image showing colocalization of dCas13X–SunTag (green) with smFISH signals (red). ACT2 mRNA was used as reporter RNA. Nuclei are stained with DAPI (blue).
image’s creator: Jiayu Zhang
040
PLOS Biology @plosbiology.org · 09/10/2026
Symbiotic #rhizobia form nitrogen-fixing partnerships with #plant roots. This study by @albinteulet.bsky.social & @dromius.bsky.social uses structural modelling to predict how secreted proteins may mimic plant factors in a strategy shared with pathogens. 🧪 #AcademicSky #symbiosis plos.io/4j6bWj0
Network-based identification of structural units (SUs) present in multiple Nop effectors.
(A) Structural similarity network of the 96 structural units (SU) extracted from AlphaFold models of the 33 Nop effectors. Each node represents one region, and edges connect pairs of regions that are structurally similar with a TM-score above 0.5. Coloured circles delimit the 13 communities containing at least two members (SU1–SU13). The remaining grey nodes correspond to the 9 singleton units. (B–N) Overlays of all structural regions belonging to each community (SU1–SU13). The putative fold or function inferred from Foldseek analysis is indicated below each panel, with the number of occurrences in each community given in parentheses.
2228
PLOS Biology @plosbiology.org · 09/10/2026
How are the #temporal patterns of sounds represented across the #auditory system at millisecond scale? This study shows that distinct click-train patterns evoke discriminable behavioral and neural responses, mapping this across the brain. 🧪 #NeuroSky plos.io/4hTU6O5
Neuronal responses to temporally merged click-train and complex tones across cortical layers in A1 in the oddball paradigm.
Left: Distribution of current source density (CSI) in the oddball paradigm (RN10, TW50) across cortical layers: supra layer (layers Ⅰ/Ⅱ, n = 30, top row), middle layer (layers Ⅲ/Ⅳ, n = 176, middle row), and deep layer (layers Ⅴ/Ⅵ, n = 465, bottom row). Arrows point to the mean.
Right: Comparison of CSI among supra, middle, and deep layers.
210
PLOS Biology @plosbiology.org · 09/10/2026
What are the #epigenetic mechanisms regulating cellular proteostasis? This study shows that a subunit of the COMPASS histone methyltransferase complex controls ultradian proteostasis gene expression through methylation at #proteostasis gene promoters. 🧪 #AcademicSky plos.io/4emgONz
This research article is titled "The histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics," by Syeda Kubra, Michelle Sun, William Dion, Yu Bian, Ahmet Catak, Hannah Luong, Haokun Wang, Yinghong Pan, Jia-Jun Liu, Aishwarya Ponna, Lijun Liu, Ian Sipula, Jian-Hua Luo, Michael J Jurczak, Silvia Liu, Bokai Zhu
201
PLOS Biology @plosbiology.org · 09/10/2026
Poorly validated #antibodies generate misleading results and waste research resources. @johanduchene.bsky.social explores two new @PLOSBiology.org studies quantifying these costs and identifying solutions. 🧪 Article 1 plos.io/3Ui0czP Article 2 plos.io/4s1Ccxl Primer plos.io/4hQh7kI
This Primer is titled, "Better antibodies, better science" by Johan Duchêne.
283
PLOS Biology @plosbiology.org · 08/10/2026
Why do some neurons die in #neurodegeneration while closely related neighbors survive? This Essay by Dong Won Kim argues that disease resistance may depend on maintenance of a neuron's #cell identity and proposes tests of the model. 🧪 #AcademicSky plos.io/4y7cGbA
Reversible cell-state remodeling vs. identity-maintenance failure in adult neurons.
An adult neuron with stable subtype identity (left) depends on continued operation of four interrelated regulatory components, shown in the inset legend: (1) identity transcription factors; (2) accessible identity enhancers; (3) coherent terminal effector gene modules; and (4) active repression of alternative gene programs belonging to other cell types. Under stress (metabolic, proteostatic, inflammatory, or pathological), the neuron can follow one of two trajectories. (A) In reversible cell-state remodeling, the neuron mounts adaptive responses such as the heat-shock response and the unfolded protein response (UPR), while identity transcription factor activity, enhancer accessibility, terminal effector modules, and repression of alternative programs remain intact. When the stress is removed, the neuron returns to its prior identity state. (B) In identity-maintenance failure, similar stress responses occur, but the regulatory machinery that stabilizes subtype identity itself weakens: identity transcription factor activity falls, identity enhancers lose accessibility, terminal effector modules decohere, and repression of alternative or neighboring-cell programs (orange) fails, allowing those programs to be expressed. After sustained disruption of this machinery, return to the prior identity state may be incomplete, delayed, or unstable even after the initiating stress is removed (broken recovery arrow), and degeneration may follow. The stress-response components are shown at comparable intensity in both panels to emphasize that the framework concerns identity-regulatory outcomes under matched stress exposure, not differences in stress response itself. Neuron illustration adapted from NIH BioArt Source, “Healthy neuron” (BIOART-000197), Public Domain, Courtesy of NIAID.
030
PLOS Biology @plosbiology.org · 08/10/2026
Moral and perceptual decisions may share computational mechanisms, but do they rely on the same neural systems? This study shows that both follow similar evidence-accumulation computations, yet engage distinct neural representations. 🧪 #NeuroSky #morality #cognition plos.io/4AM2V57
Moral and perceptual task-relevant conflict are represented by distinct brain areas. The two right temporoparietal junction clusters (rpTPJ and raTPJ) identified in different analyses had no overlap.
082
PLOS Biology @plosbiology.org · 08/10/2026
Cervical #cancer is a major cause of mortality, and the basis of disease heterogeneity in Asian populations is unclear. This study identifies key molecular pathways and biomarkers from 112 Chinese patient samples to guide therapeutic strategies. 🧪 #AcademicSky #cervicalCancer plos.io/4hCHKJS
Multiomics landscape of CN-CC samples. Overview of the experimental design and number of samples for proteomics, phosphoproteomics, WES, and RNA-seq analyses. The gray blocks in the schematic represent the missing data. The annotations to the right indicate samples in each category (bottom panel). WES, whole-exome sequencing.
011
PLOS Biology @plosbiology.org · 08/10/2026
Pathogenic bacteria in the larval #fly gut can 'prime' the adult gustatory system to recognize bacterial peptidoglycans, but how? This study identifies Uracil as the bacteria-derived cue and characterizes a larval #sensory pathway required for priming the adult. 🧪 #AcademicSky plos.io/4hK9T1R
Priming model: Larval exposure to bacteria is mandatory.
(A) Graphical representation of the priming model: adults derived from larvae raised without bacterial cohabitation do not reject sucrose + PGN mixtures. In contrast, adults from larvae cohabiting with bacteria in conventional media are attracted to sucrose but reject sucrose + PGN, a response dependent on larval Gr66a+ neurons with functional TrpA1 and adult ppk23+ cells.
120
PLOS Biology @plosbiology.org · 08/10/2026
Poorly validated #antibodies misdirect research, wasting an estimated billion dollars and millions of biological samples each year. In this multi-stakeholder Delphi consensus study, experts agree on priority practical fixes, and who should deliver them, by 2030. 🧪 #AcademicSky plos.io/3Ui0czP
Title: Actionable solutions to address antibody validation failures. By Katherine Blades, Michael Biddle, Robert Froud, Eva M Krockow, and Harvinder Virk.
1114
PLOS Biology @plosbiology.org · 08/10/2026
Researchers often select antibodies based on previous use or peer recommendations. This study shows that poor #antibody validation contributes to substantial avoidable consumption of animal and human biological samples, proposing interventions to improve #reliability. 🧪 #AcademicSky plos.io/4s1Ccxl
Self-reported antibody validation practices among researchers. Distribution of IWGAV pillar usage among survey respondents (n = 107). Of 107 respondents, 77 (72.0%) used at least one IWGAV-aligned validation strategy, while 30 (28.0%) used no IWGAV pillars, relying instead on technical controls only (n = 26) or performing no validation (n = 4). Among IWGAV users, 44 used a single pillar, 22 used two pillars, 10 used three pillars, and 1 used five pillars.
111
PLOS Biology @plosbiology.org · 08/10/2026
Visualizing #RNA dynamics in living plant cells at single transcript resolution is limited by high background fluorescence. This study develops a high signal-to-noise imaging platform that overcomes this barrier, revealing mRNA trafficking dynamics. 🧪 #AcademicSky #imaging #plants plos.io/4ARoa5k
Confocal fluorescence microscopic image showing colocalization of dCas13X–SunTag (green) with smFISH signals (red). ACT2 mRNA was used as reporter RNA. Nuclei are stained with DAPI (blue).
image’s creator: Jiayu Zhang
040
PLOS Biology @plosbiology.org · 07/10/2026
Why do some neurons die in #neurodegeneration while closely related neighbors survive? This Essay by Dong Won Kim argues that disease resistance may depend on maintenance of a neuron's #cell identity and proposes tests of the model. 🧪 #AcademicSky plos.io/4y7cGbA
Reversible cell-state remodeling vs. identity-maintenance failure in adult neurons.
An adult neuron with stable subtype identity (left) depends on continued operation of four interrelated regulatory components, shown in the inset legend: (1) identity transcription factors; (2) accessible identity enhancers; (3) coherent terminal effector gene modules; and (4) active repression of alternative gene programs belonging to other cell types. Under stress (metabolic, proteostatic, inflammatory, or pathological), the neuron can follow one of two trajectories. (A) In reversible cell-state remodeling, the neuron mounts adaptive responses such as the heat-shock response and the unfolded protein response (UPR), while identity transcription factor activity, enhancer accessibility, terminal effector modules, and repression of alternative programs remain intact. When the stress is removed, the neuron returns to its prior identity state. (B) In identity-maintenance failure, similar stress responses occur, but the regulatory machinery that stabilizes subtype identity itself weakens: identity transcription factor activity falls, identity enhancers lose accessibility, terminal effector modules decohere, and repression of alternative or neighboring-cell programs (orange) fails, allowing those programs to be expressed. After sustained disruption of this machinery, return to the prior identity state may be incomplete, delayed, or unstable even after the initiating stress is removed (broken recovery arrow), and degeneration may follow. The stress-response components are shown at comparable intensity in both panels to emphasize that the framework concerns identity-regulatory outcomes under matched stress exposure, not differences in stress response itself. Neuron illustration adapted from NIH BioArt Source, “Healthy neuron” (BIOART-000197), Public Domain, Courtesy of NIAID.
020
PLOS Biology @plosbiology.org · 07/10/2026
Cervical #cancer is a major cause of mortality, and the basis of disease heterogeneity in Asian populations is unclear. This study identifies key molecular pathways and biomarkers from 112 Chinese patient samples to guide therapeutic strategies. 🧪 #AcademicSky #cervicalCancer plos.io/4hCHKJS
Multiomics landscape of CN-CC samples. Overview of the experimental design and number of samples for proteomics, phosphoproteomics, WES, and RNA-seq analyses. The gray blocks in the schematic represent the missing data. The annotations to the right indicate samples in each category (bottom panel). WES, whole-exome sequencing.
031
PLOS Biology @plosbiology.org · 07/10/2026
Moral and perceptual decisions may share computational mechanisms, but do they rely on the same neural systems? This study shows that both follow similar evidence-accumulation computations, yet engage distinct neural representations. 🧪 #NeuroSky #morality #cognition plos.io/4AM2V57
Moral and perceptual task-relevant conflict are represented by distinct brain areas. The two right temporoparietal junction clusters (rpTPJ and raTPJ) identified in different analyses had no overlap.
0115
PLOS Biology @plosbiology.org · 07/10/2026
Pathogenic bacteria in the larval #fly gut can 'prime' the adult gustatory system to recognize bacterial peptidoglycans, but how? This study identifies Uracil as the bacteria-derived cue and characterizes a larval #sensory pathway required for priming the adult. 🧪 #AcademicSky plos.io/4hK9T1R
Priming model: Larval exposure to bacteria is mandatory.
(A) Graphical representation of the priming model: adults derived from larvae raised without bacterial cohabitation do not reject sucrose + PGN mixtures. In contrast, adults from larvae cohabiting with bacteria in conventional media are attracted to sucrose but reject sucrose + PGN, a response dependent on larval Gr66a+ neurons with functional TrpA1 and adult ppk23+ cells.
121
PLOS Biology @plosbiology.org · 06/10/2026
If you're in Heidelberg or online, attending #EMBOEvoEco, do have a chat with @plosbiology.org editor @roliroberts.bsky.social! @events.embl.org
A headshot of PLOS Biology senior editor Roli Roberts, plus details of the EMBO workshop that he's attending.
054
PLOS Biology @plosbiology.org · 06/10/2026
Why do some neurons die in #neurodegeneration while closely related neighbors survive? This Essay by Dong Won Kim argues that disease resistance may depend on maintenance of a neuron's #cell identity and proposes tests of the model. 🧪 #AcademicSky plos.io/4y7cGbA
Reversible cell-state remodeling vs. identity-maintenance failure in adult neurons.
An adult neuron with stable subtype identity (left) depends on continued operation of four interrelated regulatory components, shown in the inset legend: (1) identity transcription factors; (2) accessible identity enhancers; (3) coherent terminal effector gene modules; and (4) active repression of alternative gene programs belonging to other cell types. Under stress (metabolic, proteostatic, inflammatory, or pathological), the neuron can follow one of two trajectories. (A) In reversible cell-state remodeling, the neuron mounts adaptive responses such as the heat-shock response and the unfolded protein response (UPR), while identity transcription factor activity, enhancer accessibility, terminal effector modules, and repression of alternative programs remain intact. When the stress is removed, the neuron returns to its prior identity state. (B) In identity-maintenance failure, similar stress responses occur, but the regulatory machinery that stabilizes subtype identity itself weakens: identity transcription factor activity falls, identity enhancers lose accessibility, terminal effector modules decohere, and repression of alternative or neighboring-cell programs (orange) fails, allowing those programs to be expressed. After sustained disruption of this machinery, return to the prior identity state may be incomplete, delayed, or unstable even after the initiating stress is removed (broken recovery arrow), and degeneration may follow. The stress-response components are shown at comparable intensity in both panels to emphasize that the framework concerns identity-regulatory outcomes under matched stress exposure, not differences in stress response itself. Neuron illustration adapted from NIH BioArt Source, “Healthy neuron” (BIOART-000197), Public Domain, Courtesy of NIAID.
033
PLOS Biology @plosbiology.org · 06/10/2026
Moral and perceptual decisions may share computational mechanisms, but do they rely on the same neural systems? This study shows that both follow similar evidence-accumulation computations, yet engage distinct neural representations. 🧪 #NeuroSky #morality #cognition plos.io/4AM2V57
Moral and perceptual task-relevant conflict are represented by distinct brain areas. The two right temporoparietal junction clusters (rpTPJ and raTPJ) identified in different analyses had no overlap.
020
PLOS Biology @plosbiology.org · 06/10/2026
Cervical #cancer is a major cause of mortality, and the basis of disease heterogeneity in Asian populations is unclear. This study identifies key molecular pathways and biomarkers from 112 Chinese patient samples to guide therapeutic strategies. 🧪 #AcademicSky #cervicalCancer plos.io/4hCHKJS
Multiomics landscape of CN-CC samples. Overview of the experimental design and number of samples for proteomics, phosphoproteomics, WES, and RNA-seq analyses. The gray blocks in the schematic represent the missing data. The annotations to the right indicate samples in each category (bottom panel). WES, whole-exome sequencing.
020
PLOS Biology @plosbiology.org · 06/10/2026
Pathogenic bacteria in the larval #fly gut can 'prime' the adult gustatory system to recognize bacterial peptidoglycans, but how? This study identifies Uracil as the bacteria-derived cue and characterizes a larval #sensory pathway required for priming the adult. 🧪 #AcademicSky plos.io/4hK9T1R
Priming model: Larval exposure to bacteria is mandatory.
(A) Graphical representation of the priming model: adults derived from larvae raised without bacterial cohabitation do not reject sucrose + PGN mixtures. In contrast, adults from larvae cohabiting with bacteria in conventional media are attracted to sucrose but reject sucrose + PGN, a response dependent on larval Gr66a+ neurons with functional TrpA1 and adult ppk23+ cells.
162
PLOS Biology @plosbiology.org · 05/10/2026
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design. 🧪 #AcademicSky #virus plos.io/4rNWkD5
V1WT_06 binds to the RBD site V epitope using the heavy chain alone.
A) A closeup view of the superimposed structure of V1WT_06 bound to WIV-1 RBD on a trimeric spike (from PDB: 8WLZ). A clash with NTD of chain B is observed when V1WT_06 Fab-RBD complex is aligned onto RBD in the up conformation (chain A) in trimeric WIV-1 spike protein. Notably, the binding site is inaccessible in the RBD-down conformation. B) V1WT_06 heavy chain only interaction with WIV-1 RBD (grey). Heavy and light chains are shown with the dark and light blue ribbons, respectively. C) V1WT_06 epitope footprint overlayed with epitope footprints of other site V neutralising antibodies including S2H97, CC25.4, 5817, R1-32, and E465 patch. SARS-CoV-2 RBD (from PDB: 6m0j) is coloured based on the amino acid conservation across 87 bat sarbecoviruses.
041
PLOS Biology @plosbiology.org · 05/10/2026
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns. 🧪 #AcademicSky plos.io/4y9KgxG
Cryo-EM structure of RhGB07 trimeric spike in a 3-RBD down state. (A) Left: CryoEM density of the trimer spike coloured by the protomer chains the density originates from. Glycans are highlighted in teal. Centre: the trimeric spike viewed from the top rendered in cartoon representation. Right: the isolated RhGB07 RBD represented as cartoon in grey with two glycans of interest shown. (B) The C-alpha trace of the RBD of RhGB07 rendered as balls-and-sticks superimposed with the RBD of SARS-CoV-1 (PDB 7DF3) and SARS-CoV-2 (PDB 5X5B). The insets show a zoomed-in view of two regions of the RBD that show the greatest changes in the position of the C-alpha of the RBD. The region containing the ins1-loop and delta4-loop coincides with putative ACE2-interacting residues based on mapping the equivalent residues of SARS-CoV-1 and SARS-CoV-2. The ACE2-interacting residues were determined by superimposing SARS-CoV-1 and RhGB07 RBD onto the SARS-CoV-2 RBD – ACE2 (PDB: 6M0J) structure and identifying interacting residues. Highlighted residues of RhGB07 show the putative interacting residues that differ in identity to SARS-CoV-2.
010
PLOS Biology @plosbiology.org · 05/10/2026
Birds such as nightjars must fly at different speeds during feeding and migration. This study identifies unexpected aerodynamic and kinematic #flight features related to these ecological demands that suggest a link between wing folding and upstroke thrust generation. 🧪 #AcademicSky plos.io/3Tw3Ful
Nightjar vortex wake displays double tip vortices and upstroke thrust. Wake vortices shown as iso-surfaces of total vorticity [s−1] (iso value = 100), color-coded by downwash velocity (vz) of a sample sequence of a European nightjar flying at 9 m/s. Note the double tip vortices during the downstroke (upper inlet) and the reversed vortices at the outer wing during the upstroke (lower inlet). The inlets show in-plane velocity vectors on a background of the streamwise vorticity with blue showing clockwise rotation and yellow/red counterclockwise rotation. Vectors are not scaled the same in the two inlets but are scaled to facilitate interpretation of the flow. Units on the 3D-axes are in m.
041
PLOS Biology @plosbiology.org · 05/10/2026
As #climate warming intensifies, it remains unclear whether introgression can overcome genomic barriers to spread beneficial alleles. This study shows that strong heat selection promotes introgression and heat tolerance despite barriers to gene flow. 🧪 #AcademicSky #evolution plos.io/4i0KNwM
Comparison of introgression and strong contemporary barriers between the control and heat-selection treatments. The mean hybrid index (HI) represents the amount of introgression from the more heat-tolerant D. montana, between the control and heat-selection treatments.
051
PLOS Biology @plosbiology.org · 04/10/2026
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design. 🧪 #AcademicSky #virus plos.io/4rNWkD5
V1WT_06 binds to the RBD site V epitope using the heavy chain alone.
A) A closeup view of the superimposed structure of V1WT_06 bound to WIV-1 RBD on a trimeric spike (from PDB: 8WLZ). A clash with NTD of chain B is observed when V1WT_06 Fab-RBD complex is aligned onto RBD in the up conformation (chain A) in trimeric WIV-1 spike protein. Notably, the binding site is inaccessible in the RBD-down conformation. B) V1WT_06 heavy chain only interaction with WIV-1 RBD (grey). Heavy and light chains are shown with the dark and light blue ribbons, respectively. C) V1WT_06 epitope footprint overlayed with epitope footprints of other site V neutralising antibodies including S2H97, CC25.4, 5817, R1-32, and E465 patch. SARS-CoV-2 RBD (from PDB: 6m0j) is coloured based on the amino acid conservation across 87 bat sarbecoviruses.
0101
PLOS Biology @plosbiology.org · 04/10/2026
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns. 🧪 #AcademicSky plos.io/4y9KgxG
Cryo-EM structure of RhGB07 trimeric spike in a 3-RBD down state. (A) Left: CryoEM density of the trimer spike coloured by the protomer chains the density originates from. Glycans are highlighted in teal. Centre: the trimeric spike viewed from the top rendered in cartoon representation. Right: the isolated RhGB07 RBD represented as cartoon in grey with two glycans of interest shown. (B) The C-alpha trace of the RBD of RhGB07 rendered as balls-and-sticks superimposed with the RBD of SARS-CoV-1 (PDB 7DF3) and SARS-CoV-2 (PDB 5X5B). The insets show a zoomed-in view of two regions of the RBD that show the greatest changes in the position of the C-alpha of the RBD. The region containing the ins1-loop and delta4-loop coincides with putative ACE2-interacting residues based on mapping the equivalent residues of SARS-CoV-1 and SARS-CoV-2. The ACE2-interacting residues were determined by superimposing SARS-CoV-1 and RhGB07 RBD onto the SARS-CoV-2 RBD – ACE2 (PDB: 6M0J) structure and identifying interacting residues. Highlighted residues of RhGB07 show the putative interacting residues that differ in identity to SARS-CoV-2.
061
PLOS Biology @plosbiology.org · 04/10/2026
Birds such as nightjars must fly at different speeds during feeding and migration. This study identifies unexpected aerodynamic and kinematic #flight features related to these ecological demands that suggest a link between wing folding and upstroke thrust generation. 🧪 #AcademicSky plos.io/3Tw3Ful
Nightjar vortex wake displays double tip vortices and upstroke thrust. Wake vortices shown as iso-surfaces of total vorticity [s−1] (iso value = 100), color-coded by downwash velocity (vz) of a sample sequence of a European nightjar flying at 9 m/s. Note the double tip vortices during the downstroke (upper inlet) and the reversed vortices at the outer wing during the upstroke (lower inlet). The inlets show in-plane velocity vectors on a background of the streamwise vorticity with blue showing clockwise rotation and yellow/red counterclockwise rotation. Vectors are not scaled the same in the two inlets but are scaled to facilitate interpretation of the flow. Units on the 3D-axes are in m.
063
PLOS Biology @plosbiology.org · 04/10/2026
As #climate warming intensifies, it remains unclear whether introgression can overcome genomic barriers to spread beneficial alleles. This study shows that strong heat selection promotes introgression and heat tolerance despite barriers to gene flow. 🧪 #AcademicSky #evolution plos.io/4i0KNwM
Comparison of introgression and strong contemporary barriers between the control and heat-selection treatments. The mean hybrid index (HI) represents the amount of introgression from the more heat-tolerant D. montana, between the control and heat-selection treatments.
041
PLOS Biology @plosbiology.org · 03/10/2026
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design. 🧪 #AcademicSky #virus plos.io/4rNWkD5
V1WT_06 binds to the RBD site V epitope using the heavy chain alone.
A) A closeup view of the superimposed structure of V1WT_06 bound to WIV-1 RBD on a trimeric spike (from PDB: 8WLZ). A clash with NTD of chain B is observed when V1WT_06 Fab-RBD complex is aligned onto RBD in the up conformation (chain A) in trimeric WIV-1 spike protein. Notably, the binding site is inaccessible in the RBD-down conformation. B) V1WT_06 heavy chain only interaction with WIV-1 RBD (grey). Heavy and light chains are shown with the dark and light blue ribbons, respectively. C) V1WT_06 epitope footprint overlayed with epitope footprints of other site V neutralising antibodies including S2H97, CC25.4, 5817, R1-32, and E465 patch. SARS-CoV-2 RBD (from PDB: 6m0j) is coloured based on the amino acid conservation across 87 bat sarbecoviruses.
0103
PLOS Biology @plosbiology.org · 03/10/2026
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns. 🧪 #AcademicSky plos.io/4y9KgxG
Cryo-EM structure of RhGB07 trimeric spike in a 3-RBD down state. (A) Left: CryoEM density of the trimer spike coloured by the protomer chains the density originates from. Glycans are highlighted in teal. Centre: the trimeric spike viewed from the top rendered in cartoon representation. Right: the isolated RhGB07 RBD represented as cartoon in grey with two glycans of interest shown. (B) The C-alpha trace of the RBD of RhGB07 rendered as balls-and-sticks superimposed with the RBD of SARS-CoV-1 (PDB 7DF3) and SARS-CoV-2 (PDB 5X5B). The insets show a zoomed-in view of two regions of the RBD that show the greatest changes in the position of the C-alpha of the RBD. The region containing the ins1-loop and delta4-loop coincides with putative ACE2-interacting residues based on mapping the equivalent residues of SARS-CoV-1 and SARS-CoV-2. The ACE2-interacting residues were determined by superimposing SARS-CoV-1 and RhGB07 RBD onto the SARS-CoV-2 RBD – ACE2 (PDB: 6M0J) structure and identifying interacting residues. Highlighted residues of RhGB07 show the putative interacting residues that differ in identity to SARS-CoV-2.
0101
PLOS Biology @plosbiology.org · 03/10/2026
Birds such as nightjars must fly at different speeds during feeding and migration. This study identifies unexpected aerodynamic and kinematic #flight features related to these ecological demands that suggest a link between wing folding and upstroke thrust generation. 🧪 #AcademicSky plos.io/3Tw3Ful
Nightjar vortex wake displays double tip vortices and upstroke thrust. Wake vortices shown as iso-surfaces of total vorticity [s−1] (iso value = 100), color-coded by downwash velocity (vz) of a sample sequence of a European nightjar flying at 9 m/s. Note the double tip vortices during the downstroke (upper inlet) and the reversed vortices at the outer wing during the upstroke (lower inlet). The inlets show in-plane velocity vectors on a background of the streamwise vorticity with blue showing clockwise rotation and yellow/red counterclockwise rotation. Vectors are not scaled the same in the two inlets but are scaled to facilitate interpretation of the flow. Units on the 3D-axes are in m.
0111
PLOS Biology @plosbiology.org · 03/10/2026
As #climate warming intensifies, it remains unclear whether introgression can overcome genomic barriers to spread beneficial alleles. This study shows that strong heat selection promotes introgression and heat tolerance despite barriers to gene flow. 🧪 #AcademicSky #evolution plos.io/4i0KNwM
Comparison of introgression and strong contemporary barriers between the control and heat-selection treatments. The mean hybrid index (HI) represents the amount of introgression from the more heat-tolerant D. montana, between the control and heat-selection treatments.
070
PLOS Biology @plosbiology.org · 02/10/2026
Mounting an #immune response is energetically costly, and so host defenses are often influenced by internal metabolic states. This study identifies a gut-brain signaling mechanism in C. elegans, shaping pathogen avoidance and molecular immune responses. 🧪 #AcademicSky #hostPathogen plos.io/3T9f6bi
Conceptual diagram for how NHR-68 integrates lipid metabolism with behavioral and molecular immunity.
NHR-68 acts in the intestine to regulate linoleic acid homeostasis through control of fat-3 expression. Changes in intestinal lipid metabolism influence an AWC-dependent pathogen-avoidance circuit through currently unidentified intestine-to-neuron signaling mechanisms, enhancing survival during P. aeruginosa infection. In parallel, NHR-68 suppresses PMK-1/p38 MAPK and DAF-16/FOXO immune pathways, coordinating behavioral and molecular defenses to optimize host protection. Created in BioRender. Sang, Y. (2026).
165
PLOS Biology @plosbiology.org · 02/10/2026
Fungal biofilm formation has long been considered an important virulence trait. Shannon Esher Righi explores a new @PLOSBiology.org study challenging this idea in Candida parapsilosis outbreak isolates. 🧪 #AcademicSky #microbiology #fungi Article plos.io/4dh0tJx Primer plos.io/4hto2QF
Conceptual diagram for the trade-off between biofilm production and in vivo persistence.
Biofilm production facilitates colonization of commensal organisms, promotes adherence, and confers intrinsic antifungal resistance. Biofilm-producing strains are under tight transcriptional control and expose β-glucan. This leads to increased phagocytosis and killing by macrophages, and extracellular NET production by neutrophils. By contrast, Daneshnia and colleagues, show that low biofilm-producing strains undergo transcriptional reprogramming to allow for metabolic flexibility. They mask their β-glucan to facilitate immune avoidance, leading to decreased phagocytosis by macrophages. However, when phagocytosed, low biofilm-producing strains are more fit for growth and survival within immune cell-rich niches of the host, leading to enhanced macrophage activation and neutrophil swarming. Together these features allow low biofilm-producing C. parapsilosis strains to survive and persist within the in vivo host environment.
154
PLOS Biology @plosbiology.org · 02/10/2026
How do intrinsic timescales, which reflect the temporal window of neural processing, mature during development? This study by @goliashf.bsky.social @ted-satterthwaite.bsky.social &co identifies a hierarchical trajectory, from sensorimotor to association cortices. 🧪 #NeuroSky plos.io/46RzqRG
Developmental patterns of intrinsic timescale.
(a) Average timescale increases during development in youth  (b) Age effects quantified as partial R2 are depicted across the cortex, displaying a heterogeneous spatial distribution. (c) Age effects on intrinsic timescale were compared to the S–A axis, identifying a hierarchical pattern of developmental patterns in intrinsic timescale along the S–A axis. The results demonstrate that intrinsic timescale in association regions increases during development in youth while it remains relatively stable in sensorimotor regions.
042
PLOS Biology @plosbiology.org · 01/10/2026
How are growing vertebrate organs organized at a single-cell level? This study develops whole adult-organ expansion microscopy (WAO-ExM) to visualize every single hepatocyte in the zebrafish liver during post-embryonic growth. 🧪 #AcademicSky #Development plos.io/4d9Y9UM
Light-sheet microscopy view of a 10× expanded zebrafish liver, revealing its cellular architecture with hepatocyte membranes in green, hepatocyte nuclei in red, and nuclei of other cell types in blue.
Image credit: Image acquisition, Xuejiao Tian; image processing, Hsiao-Yuh Roan and Hsin Chen.
061
PLOS Biology @plosbiology.org · 01/10/2026
#Glia are essential for proper nervous system #development and function, but a high-resolution view of glial development is lacking. This Resource analyses longitudinal single-cell RNA sequencing of the #Drosophila visual system as glial diversity arises. 🧪 #NeuroSky plos.io/4dcP8KJ
Annotation of optic lobe glia in the larval and adult single-cell datasets.
(A) A cross-section schematic representation of the larva (L3) optic lobe with the glial cell types depicted. (C) A cross-section schematic representation of the adult stage optic lobe with the glial cell types depicted.
071
PLOS Biology @plosbiology.org · 01/10/2026
Broadly neutralizing #flu #antibodies able to recognize both influenza A and B viruses are exceptionally rare. This study shows that mutations that promote binding to one flu virus can weaken recognition of others, constraining antibody cross-reactive breadth. 🧪 #ImmuneSky plos.io/4z8mzGV
Structural analysis of the differential effects on binding affinity.
(A) The Cαs of VH S24, VH S52, VH F54, and VH I73 in CR9114 are shown as spheres (PDB 4FQI) [15]. CR9114 and HA are in blue and white, respectively. The local chemical environment for (B) VH S24, (C) VH S52 and VH F54, and (D) VH I73 are shown. Black dashed lines represent H-bonds. (E) The structure of HA-bound CR9114 with VH W73 is modeled. Red circle indicates steric clash.
042