Mohamed ElTanbouly @plasmacellguy.bsky.social · 29/09/2026And #sciencetwitter. Great place to know about new papers/preprints and hear insights about ongoing and past research. 010
Mohamed ElTanbouly @plasmacellguy.bsky.social · 16/09/2026Hello! I've started my lab and we're looking to hire at multiple positions: 1-Postdoc 2-Scientist (primarily Computational biologists) 2-Lab manager 3-Tech If you're interested, please reach out to my institutional email. Looking forward to discussing further. 084
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20268-If you have industry in mind, I don't have any useful experience to offer, so I'm sure others on here can write cogently valuable advice. 001
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20267B: Consult with your mentors, show them notes, emails, your impression. Ask around. Don't shy away from asking bold uncomfortable questions. 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20267A: Write your impressions and conclusions after each meeting if possible. Do NOT let considerable time pass between meetings/interviews and note-taking. Summarize interview notes in a table and pick what fits you best. Just as with the microbiome, include your gut feeling as part of the equation. 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20267-Take notes: as with every step in the research process, you can't only judge by memory or vibe. Take really good notes, not of what you're told, but cross-reference what people tell you. Every person has a different story based on their priorities and personality. 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20266B: Talk to existing lab members, including ones you are not assigned to meet with. Schedule a zoom call or coffee later if meeting on the interview days are not possible. 6C: Visit Core facilities 6D: Email and talk to alumni. Are those scientists where you want to be? 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20266A: Visit the place in person for more than a day (if possible). Talk to the prospective postdoc advisor MORE than once, discuss your research interests, get a feel on whether these projects are possible in their lab or whether you'll be assigned a project. 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20266-Got an interview or more? Now is the time to do a thorough job of testing whether this is a common fit. These are people you will be working with for years so you have to feel comfortable working in this settings, make sure your peers and advisor are what you need. 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20265-Cold email PIs/labs you're interested in: 5A: Include in the email why specifically you want to do a postdoc in their lab. 5B:If you see them at conferences, reach out. 5C: If your PhD advisor can or will help, ask them. 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20264-Important: Very meticulously screen for good mentors. Not only great scientists, not only successful academics/PIs, but great mentors. People who would have your back and help you grow as a scientist and person. 110
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/20262-Academia? Draft an area of investigation (question) or more you sense will keep you interested and the field moving forward for years, preferably decades. 3-Apply to labs studying overlapping, or similar questions or could allow you to develop the skills and knowledge needed to start your lab. 120
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/09/2026@jennkong.bsky.social Long answer so I am splitting it over several tweets: 1-It helps to know what you want out of a postdoc (continue academic career or go to industry or other path) #postdoc #academia #mentorship #science #questions 130
Mohamed ElTanbouly @plasmacellguy.bsky.social · 13/08/2026Terrific news! Congratulations! To many more grants, papers and milestones Highly important topic by the way. 110
Mohamed ElTanbouly @plasmacellguy.bsky.social · 02/06/2026"Timescape" by Gregory Benford "Arrowsmith" by Sinclair Lewis are worthy additions. 000
Mohamed ElTanbouly @plasmacellguy.bsky.social · 22/04/2026Everything they don't like in one sentence. Every word. 020
Mohamed ElTanbouly @plasmacellguy.bsky.social · 22/04/2026I'm surprised (and fascinated) at how nobody knew how mRNA vaccines prime CD8 T cells, despite many scientists raving about them. To my limited knowledge, this is the only example where MHC cross-dressing is a non-redundant priming pathway. 120
Mohamed ElTanbouly @plasmacellguy.bsky.social · 17/02/2026Please do. I'd appreciate it. Thank you 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 17/02/2026I found 2 professional humans via email. I guess I was impatient and too optimistic about bluesky and the other bird place. 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 17/02/2026I am looking for an Illustrator to help with making schematics and diagrams. Might anyone guide me on who to contact? Thanks #science #Illustration #Academia 20183
Mohamed ElTanbouly @plasmacellguy.bsky.social · 16/02/2026Congratulations on this amazing effort! 110
Mohamed ElTanbouly @plasmacellguy.bsky.social · 03/02/2026Do you think Histones are why multicellularity evolved? 010
Mohamed ElTanbouly @plasmacellguy.bsky.social · 12/12/2025To be completely honest, this PD-1 axis gets more confusing with time. I'm not hinting that the numerous studies are contradictory, but the nuances of expression + activity and effects of targeting are increasingly complex. 140
Mohamed ElTanbouly @plasmacellguy.bsky.social · 06/10/2025Hi Kilian, Congratulations on this truly important work. Very nicely done Glad to read the whole story. 110
Mohamed ElTanbouly @plasmacellguy.bsky.social · 06/10/2025Well, a Treg is a T cell. Although another Nobel laureate thinks (thought?) otherwise pmc.ncbi.nlm.nih.gov/articles/PMC... 230
Mohamed ElTanbouly @plasmacellguy.bsky.social · 02/09/2025Thank you :) I've been thinking about and discussing T cell tolerance with several people since the recent Belkaid and Wang papers. Planning to write something (actually wrote but need to post) about this and looking forward to your honest feedback. 020
Mohamed ElTanbouly @plasmacellguy.bsky.social · 11/07/2025Congrats Ruth and colleagues!!! I enjoyed reading this...Fascinating discovery Really great work 120
Mohamed ElTanbouly @plasmacellguy.bsky.social · 30/04/2025Congrats on your terrific effort Payal and co!!! 🎉 Very nice and comprehensive study. All the best with what comes next. 130
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/04/2025What are your thoughts on this? elifesciences.org/articles/71920elifesciences.orgNovel multicellular prokaryote discovered next to an underground streamA new bacterium isolated from an underground stream shows a novel multicellularity by self-organizing its filamentous cells like a liquid crystal and accommodating daughter cells in a sequential manne... 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 03/04/2025Might I ask you if any of these talks are available on NIHvideocast or youtube? Or accessible online? 110
Mohamed ElTanbouly @plasmacellguy.bsky.social · 25/01/2025I tried to access but it says that it's only available to Harvard folks What am I missing? Aside from a Harvard ID card 000
Mohamed ElTanbouly @plasmacellguy.bsky.social · 23/01/2025On an irrelevant note, congratulations on this terrific paper www.nature.com/articles/s41...nature.comTissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - NatureProfiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t... 010
Mohamed ElTanbouly @plasmacellguy.bsky.social · 23/01/2025This is fascinating! These are all immune (lymphocyte-relevant) genes!!!!! 010
Mohamed ElTanbouly @plasmacellguy.bsky.social · 16/01/2025Mitochondria is the powerhouse of the cell Chloroplast is the cell's farm ER is the factory and ribosomes are the workers Plasma membrane are the city walls Cilia and flagella are the stirring wheels and propellers Exosomes and endosomes are the email/post office 130
Mohamed ElTanbouly @plasmacellguy.bsky.social · 12/01/2025Many thanks for all these terrific insights. 020
Mohamed ElTanbouly @plasmacellguy.bsky.social · 12/01/2025Tcf7 activates genes with CTNNB1 (β-catenin)? What signals are upstream of this? Or are they constitutively active? 110
Mohamed ElTanbouly @plasmacellguy.bsky.social · 11/01/2025Congrats @danmcmanus123.bsky.social Very nice work! 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 10/01/2025Unrelated request: Would be nice if someone figured out what maintains Tcf7 expression and activity in CD8 stemlike (± mem T cells). It was argued in a recent conference that it's Wnt signaling but I can't see how in the absence of Fzd expression in T cells. 110
Reposted by Mohamed ElTanboulyKilian Schober @kischober.bsky.social · 10/01/2025Clones usually encompass cell members with heterogenous cell states, too. 121
Mohamed ElTanbouly @plasmacellguy.bsky.social · 10/01/2025I think they need Il7r re-expression (and Il2r downregulation) www.nature.com/articles/ni1... www.sciencedirect.com/science/arti...nature.comSelective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells - Nature ImmunologyNature Immunology - Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells 130
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/01/20251-This paper? www.nature.com/articles/s41... Might you elaborate on where they discussed this (PD-1) here? I recall they assessed "renewal potential" (Tcm-ness based on prior division no. and quiescence state) 2-Looking forward to reading your group's findings. Sounds very interesting.nature.comReplicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool - Nature ImmunologySchumacher and colleagues have designed a reporter system that allows in vivo tracking of replicative history over many cell generations. Using this system to study acute T cell responses, they uncove... 120
Mohamed ElTanbouly @plasmacellguy.bsky.social · 09/01/2025They're memory precursors. When antigen goes away, most clones contract and these cells make up the central memory (Tcm). In chronic infection, they act as transient amplifiers differentiating into terminal eff and new precursors. 340
Mohamed ElTanbouly @plasmacellguy.bsky.social · 29/12/20241-Incredible figure presentation and clarity 2-Eight years of work 3-Favorite statement (reminded me of another statement in an equally authoritative paper). Both are presented in screenshots below. 4-Builds upon earlier work by Peng et al from Jameson group www.sciencedirect.com/science/arti... 081
Mohamed ElTanbouly @plasmacellguy.bsky.social · 22/12/2024Thank you :) for the very kind feedback. I'm still enjoying it so will keep summarizing/reviewing All the best with your work + life 020
Mohamed ElTanbouly @plasmacellguy.bsky.social · 19/12/2024Could I ask your take on the data showing "Treg conversion to Tfh"? What (signals) persuades them? PMID: 39662506 PMID: 19286559 100
Mohamed ElTanbouly @plasmacellguy.bsky.social · 13/12/2024Unsolicited feedback: This sounds so cool. Can't wait to read your findings. All the best with this (and everything, but primarily this). 000